Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지
DOI QR코드

DOI QR Code

Mushrooms: An Important Source of Natural Bioactive Compounds

  • Ha, Ji Won (School of Pharmacy, Sungkyunkwan University) ;
  • Kim, Juhui (School of Pharmacy, Sungkyunkwan University) ;
  • Kim, Hyunwoo (School of Pharmacy, Sungkyunkwan University) ;
  • Jang, Wonyoung (School of Pharmacy, Sungkyunkwan University) ;
  • Kim, Ki Hyun (School of Pharmacy, Sungkyunkwan University)
  • Received : 2020.05.08
  • Accepted : 2020.06.09
  • Published : 2020.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Mushrooms are known for their various attributes in the fields of nutrition and therapeutics. With exceptional taste, aroma, and nutritional value, they are considered 'functional food'-improving health and providing nutritional benefits to the body. Mushrooms have also been widely applied therapeutically as they possess diverse bioactive compounds known as secondary metabolites. These secondary metabolites demonstrated diverse biological properties such as anticancer, anti-diabetic, immunomodulatory, antimicrobial, anti-inflammatory, antiviral, anti-allergic, and antioxidative activities. This review presents bioactive compounds from the field of mushroom metabolite research and discusses important findings regarding bioactive compounds identified during the last five years (2015 - 2019).

Keywords

References

  1. Jiangsu New Medical College. Chinese Material Medica; Shanghai People's Publishing House: Shanghai, 1977, p 1784.
  2. Kashiwada, Y.; Sekiya, M.; Yamazaki, K.; Ikeshiro, Y.; Fujioka, T.; Yamagishi, T.; Kitagawa, S.; Takaishi, Y. J. Nat. Prod. 2007, 70, 623-627. https://doi.org/10.1021/np060631s
  3. Lee, M.; Sung, S. H. Pharmacogn. Mag. 2016, 12, 276-281. https://doi.org/10.4103/0973-1296.192208
  4. Kim, S.; So, H. M.; Roh, H. S.; Kim, J.; Yu, J. S.; Lee, S.; Seok, S; Pang, C. H.; Baek, K. H.; Kim, K. H. RSC Adv. 2017, 7, 35297-35304. https://doi.org/10.1039/C7RA05059C
  5. Wang, K.; Bao, L.; Qi, Q.; Zhao, F; Ma, K.; Pei, Y.; Liu, H. J. Nat. Prod. 2015, 78, 146-154. https://doi.org/10.1021/np5004388
  6. Wu, Z.; Li, Y. Oncotarget 2017, 8, 21454-21460. https://doi.org/10.18632/oncotarget.15250
  7. Vanyolos, A.; Dekany, M.; Kovacs, B.; Kramos, B.; Berdi, P.; Zupko, I.; Hohmann, J.; Beni, Z. Org. Lett. 2016, 18, 2688-2691. https://doi.org/10.1021/acs.orglett.6b01158
  8. Li, X.; He, Y.; Zeng, P.; Liu, Y.; Zhang, M.; Hao, C.; Wang, H.; Lv, Z.; Zhang, L. J. Cell. Mol. Med. 2019, 23, 4-20. https://doi.org/10.1111/jcmm.13564
  9. Zhang, B.; Li, Y.; Zhang, F.; Linhardt, R. J.; Zeng, G.; Zhang, A. Int. J. Biol. Macromol. 2019, 150, 1342-1347. https://doi.org/10.1016/j.ijbiomac.2019.10.144
  10. Xue, Z.; Li, J.; Cheng, A.; Yu, W.; Zhang, Z.; Kou, X.; Zhou, F. Plant Foods Hum. Nutr. 2015, 70, 291-296. https://doi.org/10.1007/s11130-015-0492-7
  11. Ruan, W.; Wei, Y; Popovich, D. G. Phytother. Res. 2015, 29, 1744-1752. https://doi.org/10.1002/ptr.5426
  12. Pleszczynska, M.; Lemieszek, M. K.; Siwulski, M; Wiater, A.; Rzeski, W.; Szczodrak, J. Wolrd J. Microbiol. Biotechnol. 2017, 33, 83. https://doi.org/10.1007/s11274-017-2247-0
  13. Angamuthu, V.; Shanmugavadivu, M.; Nagarajan, G; Velmurugan, B. K. Chem. Biol. Interact. 2019, 297, 8-15. https://doi.org/10.1016/j.cbi.2018.10.009
  14. Chang, T. C.; Yeh, C. T.; Adebayo, B. O.; Lin, Y. C.; Deng, L.; Rao, Y. K.; Huang, C. C.; Lee, W. H.; Wu, A. T. H.; Hsiao, M.; Wu, C. H.; Wang, L. S.; Tzeng, Y. M. Toxicol. Appl. Pharmcol. 2015, 288, 258-268. https://doi.org/10.1016/j.taap.2015.07.025
  15. Peng, X. R.; Su, H. G.; Liu, J. H.; Huang, Y. J.; Yang, X. Z.; Li, Z. R.; Zhou, L.; Qiu, M. H. J. Agric. Food Chem. 2019, 67, 10330-10341. https://doi.org/10.1021/acs.jafc.9b04530
  16. Zhang, H.; Shao, Q.; Wang, W.; Zhang, J.; Zhang, Z.; Liu, Y.; Yang, Y. Molecules 2017, 22, 698. https://doi.org/10.3390/molecules22050698
  17. Kumar, K. J. S.; Vani, M. G.; Hsieh, H. W.; Lin, C. C.; Wang, S. Y. Planta Med. 2019, 85, 755-765. https://doi.org/10.1055/a-0942-2087
  18. Wu, T. R.; Huang, T. T.; Martel, J.; Liau, J. C.; Chiu, C. Y.; Leu, Y. L.; Jian, W. T.; Chang, I. T.; Lu, C. C.; Ojcius, D. M.; Ko, Y. F.; Lai, H. C.; Young, J. D. J. Ethnopharmacol. 2017, 201, 117-122. https://doi.org/10.1016/j.jep.2017.02.008
  19. Feng, T.; Cai, J. L.; Li, X. M.; Zhou, Z. Y.; Li, Z. H.; Liu, J. K. J. Agric. Food Chem. 2016, 64, 1945-1949. https://doi.org/10.1021/acs.jafc.6b00176
  20. Zhang, S. D.; Yu, L.; Wang, P.; Kou P.; Li, J.; Wang, L. T.; Wang, W.; Yao, L. P.; Zhao, X. H.; Fu, Y. J. Phytomedicine 2019, 60, 152957. https://doi.org/10.1016/j.phymed.2019.152957
  21. Baek, J. W.; Roh, H. S.; Baek, K. H.; Lee, S.; Lee, S.; Song, S. S.; Kim, K. H. J. Ethnopharmacol. 2018, 224, 63-75. https://doi.org/10.1016/j.jep.2018.05.025
  22. Fernando, D.; Adhikari, A.; Nanayakkara, C.; de Silva, E. D.; Wijesundera, R.; Soysa, P. BMC Complement. Altern. Med. 2016, 16, 484. https://doi.org/10.1186/s12906-016-1471-8
  23. Chen, S. Y.; Chang, C. L.; Chen, T. H.; Chang, Y. W.; Lin, S. B. Fitoterapia 2016, 114, 81-91. https://doi.org/10.1016/j.fitote.2016.08.015
  24. Kuo, Y. H.; Lin, C. H.; Shih, C. C. Int. J. Mol. Sci. 2016, 17, 872. https://doi.org/10.3390/ijms17060872
  25. Huang, H. T.; Wang, S. L.; Nguyen, V. B.; Kuo, Y. H. Molecules 2018, 23, 2864. https://doi.org/10.3390/molecules23112864
  26. Fu, H.; Deng, C.; Teng, L.; Yu, L.; Su, T.; Xu, X.; Chen, J.; Yang, C. Int. J. Med. Mushrooms 2015, 17, 151-160. https://doi.org/10.1615/IntJMedMushrooms.v17.i2.60
  27. Habtemariam, S. Biomedicines 2019, 7, 98. https://doi.org/10.3390/biomedicines7040098
  28. Duru, M. E.; Cayan, G. T. Rec. Nat. Prod. 2015, 9, 456-483.
  29. Yoon, J. Y.; Kim, J. H.; Baek, K. S.; Kim, G. S.; Lee, S. E.; Lee, D. Y.; Choi, J. H.; Kim, S. Y.; Park, H. B.; Sung, G. H.; Lee, K. R.; Cho, J. Y.; Noh, H. J. Pharmacogn. Mag. 2015, 11, 477-485. https://doi.org/10.4103/0973-1296.160454
  30. L ee, S .; L ee, D.; Park, J. Y.; S eok, S .; J ang, T. S.; Park, H . B.; Shim, S. H.; Kang, K. S.; Kim, K. H. J. Pharm. Pharmacol. 2018, 70, 404-412. https://doi.org/10.1111/jphp.12871
  31. Tomas-Hernandez, S.; Garcia-Vallve, S.; Pujadas, G.; Valls, C.; Ojeda-Montes, M. J.; Gimeno, A.; Cereto-Massague, A.; Roca-Martinez, J.; Suarez, M.; Arola, L.; Blanco, J.; Mulero, M.; Beltran-Debon, R. J. Agric. Food Chem. 2018, 66, 10952-10963. https://doi.org/10.1021/acs.jafc.8b00782
  32. Kim, J. E.; Takanche, J. S.; Yun, B. S.; Yi, H. K. J. Periodont. Res. 2018, 53, 816-824. https://doi.org/10.1111/jre.12570
  33. Chen, H. P.; Zhao, Z. Z.; Li, Z. H.; Huang, Y.; Zhang, S. B.; Tang, Y.; Yao, J. N.; Chen, L.; Isaka, M.; Feng, T.; Liu, J. K. J. Agric. Food Chem. 2018, 66, 3146-3154. https://doi.org/10.1021/acs.jafc.8b00287
  34. Lee, S.; Lee, D.; Lee, J. C.; Kang, K. S.; Ryoo, R.; Park, H. J.; Kim, K. H. Chem. Biodivers. 2018, 15, e1800203. https://doi.org/10.1002/cbdv.201800203
  35. Kim, C. S.; Moon, E.; Choi, S. U.; Kim, S. Y.; Lee, K. R.; Kim, K. H. J. Antibiot. 2015, 68, 414-416. https://doi.org/10.1038/ja.2015.2
  36. Lu, M. Y.; Chen, C. C.; Lee, L. Y.; Lin, T. W.; Kuo, C. F. J. Nat. Prod. 2015, 78, 2452-2460. https://doi.org/10.1021/acs.jnatprod.5b00573
  37. Saiki, P.; Kawano, Y.; Van Griensven, L. J. L. D.; Miyazaki, K. Food Funct. 2017, 8, 4150-4158. https://doi.org/10.1039/c7fo01172e
  38. Nishio, A.; Mikami, H.; Imagawa, H.; Hashimoto, T.; Tanaka, M.; Ito, T.; Iuchia, M.; Iseki, K.; Noji, M.; Umevama, A. Nat. Prod. Commun. 2016, 11, 1147-1149.
  39. Beni, Z.; Dekany, M.; Kovacs, B.; Csupor-Loffler, B.; Zomborszki, Z. P.; Kerekes, E.; Szekeres, A.; Urban, E.; Hohmann, J.; Vanyolos, A. Molecules 2018, 23, 1082. https://doi.org/10.3390/molecules23051082
  40. Chepkirui, C.; Cheng, T.; Matasyoh, J.; Decock, C.; Stadler, M. Phytochem. Lett. 2018, 25, 141-146. https://doi.org/10.1016/j.phytol.2018.04.022
  41. Rezaeian, S.; Pourianfar, H. R. Int. J. Adv. Res. 2016, 4, 426-249. https://doi.org/10.21474/IJAR01/977
  42. Sadorn, K.; Saepua, S.; Boonyuen, N.; Laksanacharoen, P.; Rachtawee, P.; Pittayakhajonwut, P. RSC Adv. 2016, 6, 94510-94523. https://doi.org/10.1039/C6RA21898A
  43. Bunbamrung, N.; Intaraudom, C.; Dramae, A.; Boonyuen, N.; Veeranondha, S.; Rachtawee, P.; Pittayakhajonwut, P. Phytochem. Lett. 2017, 20, 274-281. https://doi.org/10.1016/j.phytol.2017.05.017
  44. Basnet, B. B.; Liu, L.; Bao, L.; Liu, H. Mycology 2017, 8, 111-124. https://doi.org/10.1080/21501203.2017.1324529
  45. Perfileva, A. I.; Tsivileva, O. M.; Ibragimova, D. N.; Koftin, O. V.; Fedotova, O. V. Mikrobioloqiia 2017, 86, 172-181.
  46. Tang, C.; Hoo, P. C.; Tan, L. T.; Pusparajah, P.; Khan, T. M,; Lee, L. H.; Goh, B. H.; Chan, K. G. Front. Pharmacol. 2016, 7, 474. https://doi.org/10.3389/fphar.2016.00474
  47. Huang, Y.; Zhang, S. B.; Chen, H. P.; Zhao, Z. Z.; Zhou, Z. Y.; Li, Z. H.; Feng, T.; Liu, J. K. J. Agric. Food Chem. 2017, 65, 3835-3841. https://doi.org/10.1021/acs.jafc.7b00899
  48. Sandargo, B.; Michehl, M.; Praditya, D.; Steinmann, E.; Stadler, M.; Surup, F. Org. Lett. 2019, 21, 3286-3289. https://doi.org/10.1021/acs.orglett.9b01017
  49. Ren, G.; Xu, L.; Lu, T.; Yin, J. Int. J. Biol. Macromol. 2018, 115, 1202-1210. https://doi.org/10.1016/j.ijbiomac.2018.04.132
  50. Hwang, B. S.; Lee, I. K.; Choi, H. J.; Yun, B. S. Bioorg. Med. Chem. Lett. 2015, 25, 3256-3260. https://doi.org/10.1016/j.bmcl.2015.05.081
  51. Kawai, J.; Higuchi, Y.; Hirota, M.; Hirasawa, N.; Mori, K. Biosci. Biotechnol. Biochem. 2018, 82, 1803-1811. https://doi.org/10.1080/09168451.2018.1490169
  52. Wang, Z.; Liu, J.; Zhong, X.; Li, J.; Wang, X.; Ji, L.; Shang, X. Molecules 2019, 24, 3014. https://doi.org/10.3390/molecules24163014
  53. Tamrakar, S.; Fukami, K.; Parajuli, G. P.; Shimizu, K. J. Med. Food 2019, 22, 225-227. https://doi.org/10.1089/jmf.2018.4267
  54. Zan, L. F.; Bao, H. Y.; Bau, T.; Li, Y. Nat. Prod. Commun. 2015, 10, 315-316.
  55. Kruzselyi, D.; Vetter, J.; Ott, P. G.; Darcsi, A.; Beni, S.; Gomory, A.; Drahos, L.; Zsila, F.; Moricz, A. M. Fitoterapia 2019, 137, 104180. https://doi.org/10.1016/j.fitote.2019.104180
  56. Li, W.; Lee, S. H.; Jang, H. D.; Ma, J. Y.; Kim, Y. H. Molecules 2017, 22, 108. https://doi.org/10.3390/molecules22010108
  57. Pattanayak, M.; Maity, P.; Samanta, S.; Sen, I. K.; Manna, D. K.; Nandi, A. K.; Ghosh, S.; Acharya, K.; Islam, S. S. Int. J. Biol. Macromol. 2018, 107, 322-331. https://doi.org/10.1016/j.ijbiomac.2017.08.163
  58. Panda, B. C.; Maity, P.; Nandi, A. K.; Pattanayak, M.; Manna, D. K.; Mondal, S.; Tripathy, S.; Roy, S.; Acharya, K.; Islam, S. S. Int. J. Biol. Macromol. 2017, 95, 833-842. https://doi.org/10.1016/j.ijbiomac.2016.11.121
  59. Lin, K. W.; Maitraie, D.; Huang, A. M.; Wang, J. P.; Lin, C. N. Fitoterapia 2016, 108, 73-80. https://doi.org/10.1016/j.fitote.2015.11.003
  60. Peng, X.; Li, L.; Wang, X.; Zhu, G.; Li, Z.; Qiu, M. Fitoterapia 2016, 111, 18-23. https://doi.org/10.1016/j.fitote.2016.04.006

Cited by

  1. Ginkwanghols A and B, osteogenic coumaric acid-aliphatic alcohol hybrids from the leaves of Ginkgo biloba vol.44, pp.5, 2020, https://doi.org/10.1007/s12272-021-01329-3
  2. Bioactive Phytochemicals from Mulberry: Potential Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages vol.22, pp.15, 2021, https://doi.org/10.3390/ijms22158120