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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Lysophosphatidylcholine aggravates contact hypersensitivity by promoting neutrophil infiltration and IL17 expression

  • Song, Mi Hye (Department of Pathology, Hallym University College of Medicine) ;
  • Gupta, Anupriya (Department of Pathology, Hallym University College of Medicine) ;
  • Kim, Hye One (Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Oh, Kwonik (Department of Pathology, Hallym University College of Medicine)
  • Received : 2020.09.08
  • Accepted : 2020.11.04
  • Published : 2021.04.30
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Abstract

Lysophosphatidylcholine (LPC) is a bioactive lysolipid known to contribute to the development of lung allergic diseases. However, it remains unknown whether LPC possesses proinflammatory properties in the skin as well. Here, we investigated this issue by injection of LPC into the murine contact hypersensitivity (CHS) model induced by 2,4-dinitrofluorobenzene (DNFB). LPC increased the expression of IL17, recruited more neutrophils, and eventually aggravated the CHS in the skins. Moreover, the effects of LPC diminished after neutralizing IL17 or depleting neutrophils. Mechanistically, LPC upregulated not only IL17 but also CXCL1 and CXCL2 in a G2A-dependent manner. Taken together, our study demonstrated that the upregulation of LPC could contribute to allergic skin inflammation by increasing IL17 expression and neutrophil recruitment via G2A receptor.

Keywords

Acknowledgement

This work was supported by NRF of Korea (2018R1D1A1B0704642813), Hallym University (H20160646) and Korea Healthcare R&D project (HI17C0597).

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