Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Biodegradable Inorganic-Organic Composite Artiticial Bone Substitue -Part2. Collagen purification and its physical and biological properties-

  • Hwal Suh (Institute of Biomedical Engineering, College of Medicine, Seoul National University)
  • Published : 1994.09.01
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Abstract

To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atel- ocollagen was produced. The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength.

Keywords

References

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