Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effects of Oral Taurine Supplementation on Plasma Total and Phospholipid Fatty Acid Patterns in Healthy Female Adults

타우린 복용이 정상 성인여성의 혈장 총지방산 및 인지질 지방산패턴에 미치는 영향

  • Published : 1998.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Effect of oral taurine supplementation on plasma total and phospholidpid -fatty acid profiles and their metabolism were evaluated in healthy female adults. Among twenty five female volunteers(23.6$\pm$0.3 years old ) participated in the taruine supplementation program(6g taurine /day), twenty four subjects succesfully completed the 2 week program , and only nine subjects continued to take taurine for another 2 weeks. Levels of plasma fatty acids and taruine were measured by gas-liquid chromatobraphy and an automated amino acid analyzer based on ion exchange chromatography, respectively. Plasma taurine concentration s of the subjects were 108. 7$\pm$3.4 , 184.2$\pm$8.2 and 235.9$\pm$77.0$\mu$emol/L at 0 , 2 and 4 weeks of taurine supplementation. Fatty acid compositions and elongation and desaturation indices of polyunsaturated fatty acids (PUFA) in plasma total lipids were not influenced by oral taurine supplementation. However, fatty acid compositions and their metabolism in plasma phospholipids were significantly affected by taurine supplementation in female adults. Compared to the values for 0 week, the percentage of saturated fatty acids (SFA) in plasma phospholipid was significantly lowered at 2 weeks, but elevated at 4 weeks of taurine supplementation. In contrast , the percentage of phospholipid PUFA significantly increased at 2 weeks and decreased at 4 weeks of taurine supplementation from to the values for 0 weeks. Foru weeks of oral taurine supplementation signifinatly elevated the eongation index(20 : 4$\omega$6 ⇒22 : 4 $\omega$6, p<0.01), and decreased the desaturation index (20 : 3 $\omega$6 ⇒20 : 4 $\omega$6 , p<0.01) of $\omega$6 fatty acids in plasma phospholipids. Plasma taurine concentration was positively correlated with the percentage of 14 : 0 fatty acids and the enlongation index o f$\omega$3 fatty acids(20 : 5 $\omega$3 ⇒22 : 5 $\omega$3), and thenegatively correlated with the percentage of 20 : 0 in plasma phospholipids. These results indicate that oral taurine supplementation for 4 weeks signidicantly elelvated the percentage of SFA, and lowered the percentage of PUFA in plasma phospholipids with no influence on plasm total fatty aicd composition in healthy female adults.

Keywords

References

  1. Hepatology v.2 The effect of tauroursodeoxycholic acid and taurine supplementation on biliary bile acid composition Batta,A.K.;Salen,G.;Shefer,S.;Tint,G.S.;Dayal,B.
  2. Lipids v.15 Effect of dietary taurine on bile acid metabolism in guinea pigs Kibe,A.;Wake,C.;Kuramoto,T.;Hoshita,T.
  3. Am J Clin Nutr v.34 Bile lipid alterations in taurine-depleted monkeys Stephan,Z.F.;Armstrong,M.J.;Hayes,K.C.
  4. J Lab Clin Med v.101 Bile salt-associated electrolyte secretion and the effect of sodium tauro-cholate on bile flow Strasberg,S.M.;Lison,R.G.;Palopheimo,J.E.
  5. Proc Soc Exp Biol Med v.202 Effect of taurine levels on liver lipid metabolism : an in vivo study in the rat Yan,C.C.;Bravo,E.;Cantafora,A.
  6. Nutr Res v.18 no.9 Dietary taurine supplementation reduces plasma and liver cholesterol and triglyceride concentrations in rats fed a high-cholesterol diet Park,T.;Lee,K.S.;Um,Y.S.
  7. Kor J Nutr v.30 no.10 Effect of dietary taurine supplementation on plasma and liver lipid levels in rats fed a cholesterol-free diet Park,T.;Lee,K.S.
  8. Ind J Exp Biol v.30 Hypolipidemic action of taurine in rats Gandhi,V.M.;Cherian,K.M.;Mulky,M.J.
  9. J Nutr v.127 Dietary eritadenine modifies plasma phosphatidylcholine molecular species profile in rats fed different types of fat Sugiyama,K.;Yamakawa,A.;Kawagishi,H.;Saeki,S.
  10. Lipids v.31 Dietary eritadenine-induced alteration of molecular species composition of phospholipids in rats Sugiyama,K.;Yamakawa,A.
  11. Nutr Sci Soy Protein Jpn v.12 Relationship between plasma cholesterol lowering effect of soybean protein isolate and phospholipid biosynthesis in rats Sugiyama,K.;Yamakawa,A.;Kanamori,H.;Muramatsu,K.
  12. Am J Clin Nutr v.63 Effect of n-3 polyunsaturated fatty acid intake on phospholipids fatty acid composition in plasma and erythrocytes Prisco,D.;Eilippini,M.;Francalanci,I.;Paniccia,R.;Gensiri,G.F.;Abbate,R.;Sernei,G.G.N.
  13. J Lipid Res v.27 Comparative studies on the substrate specificity of lecithin : cholesterol acyltransferase in the plasma of 14 vertebrates Subbaiah,P.V.;Liu,M.
  14. Biochem J v.310 Variation in composition of dietary fats affect hepatic uptake and metabolism of chylomicron remnants Lambert,M.S.;Botham,K.M.;Mayes P.A.
  15. Kor J Nutr v.31 no.1 Taurine concentrations are closely correlated with fatty acids concentrations in breast milk from Koreans Park,T.;Chung,E.J.;Um,Y.S.;Moon,S.J.;Lee-Kim,Y.C.
  16. Asia Pacific J Clin Nutr v.7 no.1 Relationship between fatty acid compositions and taurine concentration in breast milk from Chinese rural mothers Lee-Kim,Y.C.;Park,T.;Chung,E.J.;Um,Y.S.;Lei,S.;Xiang,M.;Li,T.
  17. J Biol Chem v.2 A simple method for the isolation and purfication of total lipids from animal tissues Folch,J.;Lees,M.;Sloone-Stanley,G.H.
  18. J Lipid Res v.27 Direct transesterification of all classes of lipids in a one-step reaction Lepage,G.;Roy,C.C.
  19. Methods in Enzymolozy v.6 Chromatographic determination of amino acids by the use of automatic recording equipment Moore,S.;Stein,W.H.;Colowick,S.P.(ed.);Kaplan,N.O.(ed.)
  20. Br J Nutr v.56 Taurine concentrations in the diet, plasma, urine and breast milk of vegans compared with omnivores Rana,S.K.;Sanders,T.A.B.
  21. J Pediatr v.111 Taurine supplementation, fat absorption and growth in cystic fibrosis Thompson,G.N.;Robb,T.A.;Davidson,G.P.
  22. Pediatrics v.7 Feeding the low-birth-weight infant.Ⅱ .Effect of Taurine and cholesterol supplementation on amino acids and cholesterol Rassin,K.;Gaull,G.E.;Jarvenpao,A.L.;Raiah,N.C.R.
  23. Pedial Res v.21 Taurine concentrations in plasma, blood cells and urine of children undergoing long-term total parental nutrition Vinton,N.E.;Laidlaw,S.A.;Ament,M.E.;Kopple,J.D.
  24. Kor J Nutr v.31 no.2 Effects of dietary taurine or glycine supplementation on plasma and liver free amino acid concentrations in rats Park,J.E.;Cha,H.S.;Park,T.
  25. Kor J Nutr v.28 no.9 Effect of dietary taurine on free amino acid concentrations in blood and various tissues of cats Park,T.;Rogers,Q.R.
  26. J Nutr v.119 Effect of dietary taurine on renal taurine transport by proximal tubule brush border membrane vesicles in the kitten Park,T.;Rogers,Q.R.;Morris,J.G.;Chesney,R.W.
  27. Kor J Nutr v.28 no.10 Relationship between plasma,erythrocyte membrane and dietary intake levels of ω3 fatty acids in young Korean females : Effect of diet survey for two months Han,E.K.;Paik,H.Y.
  28. Kor J Nutr v.28 no.7 Dietary lipid, plasma lipoprotein and fatty acid composition of young Korean women Kim,K.G.;Lim,H.S.
  29. Korean J Lipidol v.5 no.2 Fatty acid intake pattern and compositions of serum phospholipids-fatty acids of the Koreans Adults Oh,K.W.;Lee,S.I.;Song,K.S.;Nam,C.M.;Kim,Y.O.;Lee,Y.C.
  30. Kor J Nutr v.30 no.4 Effect of dietary fatty acids on serum lipids and fatty acid composition of serum phospholipids in men Oh,E.J.;Kwon,J.S.;Chang,Y.K.
  31. Am J Clin Nutr v.61 Omega-3 fatty acids in adipose tissue of obese patients with non-insulin-dependent diabetes mellitus reflect long term dietary intake of eicosapentaenoic acid and docosahexaenoic acid Popp-Snijders,C.;Block,M.C.
  32. J Nutr v.121 Dietary taurine content changes liver lipids in cats Cantafora,A.;Blotta,I.;Rossi,S.S.;Hofmann,A.F.;Sturman,J.A.
  33. Biochim Biophys Acta v.922 Cholesterol-induced microsomal changes modulate desaturase activities Leikin,A.I.;Brenner,R.R.
  34. Lipids v.7 The activating effect of dietary protein on linoleic acid desaturation Peluffo,R.O.;de Gormez Dumm,I.N.T.;Brenner,R.R.B.
  35. J Nutr v.101 Effect of protein and insulin on linoleic acid desaturation of normal and diabetic rats Peluffo,R.O.;de Gormez Dumm,I.N.T.;de Alaniz,M.M.T.;Brenner,R.R.B.
  36. Arch Biochem Biophys v.16 Steroyl coenzyme A desaturase activity in mouse liver microsomes of varying lipid compositions Holloway,C.T.;Holloway,P.W.
  37. Biochim Biophys Acta v.819 no.1 In vitro modification of cholesterol content of rat liver microsomes : Effects upon membrane fluidity and activities of glucose-6-phosphatase and fatty acid desaturation systems Garda,H.A.;Brenner,R.R.