YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Antifungal Activities of trans-Cinnamaldehyde Derivatives

trans-Cinnamaldehyde 유도체의 항진균활성 검색

  • 방규호 (코오롱제약(주) 기술연구소) ;
  • 조근희 (대전시 보건환경연구원 약품화학과) ;
  • 이영하 (충남대학교 미생물학과)
  • Published : 2001.10.01
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Abstract

Antifungal activities of trans-cinnamaldehyde (CA) derivatives including commercial CA derivatives as well as synthesized CA derivatives against various human pathogenic fungi were investigated. Among the derivatives tested, -chlorocinnamaldehyde, $\alpha$-bromocinnamaldehyde and 7-phenyl-2,4,6-heptatrienal were more potent than CA in antifungal activity, $\alpha$-Bromocinnamaldehyde was the most effective in inhibiting the growth of representative fungi of dermatomycosis with minimum inhibitory cocentration(MIC) of 0.61~9.76$\mu\textrm{g}$/ml . In the structure-activity relationship, introduction of the chlorine and bromine group into the C-2 of CA resulted in the decrease of MIC. Derivative with more double bonds exhibited the increase of antifungal activity against various pathogenic fungi.

Keywords

References

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