Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Development of Medium for Griseofulvin Production: Part I. Screening of Medium Constituents Using the Plackett-Burman Experimental Design

  • Venkata, Dasu-V. (Biotechnology Research Centre, Department of Chemical Engineering, Indian Institute of Technology-madras) ;
  • Panda, T. (Biotechnology Research Centre, Department of Chemical Engineering, Indian Institute of Technology-Madras) ;
  • Chidambaram, M. (Biotechnology Research Centre, Department of Chemical Engineering, Indian Institute of Technology-Madras)
  • Published : 2002.06.01
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Abstract

The Plackett-Burman experimental design was employed to evaluate the relative importance of medium constituents of each medium for enhanced griseofulvin production by Penicillium griseofulvum MTCC 1898 and Penicillium griseofulvum MTCC 2004. It was found that the medium constituents, sucrose, $K_2HPO_4,\;NaNO_3,\;and\;FeSO_4{\cdot}7H_2O$, significantly influenced the griseofulvin production by Penicillium griseofulvum MTCC 1898. In the case of Penicillium griseofulvum MTCC 2004, lactose, glucose, and $MnSO_4{\cdot}H_2O$ significantly influenced the griseofulvin production.

Keywords

References

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