Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Antimicrobial Effects of Ocotillone Isolated from Stem Bark of Ailanthus altisshima

  • Lee, Dong-Gun (Research Center for Proteineous Materials, Chosun University) ;
  • Chang, Young-Su (College of Pharmacy, Chosun University, Research Center for Proteineous Materials, Chosun University) ;
  • Park, Yoon-Kyung (Research Center for Proteineous Materials, Chosun University) ;
  • Hahm, Kyung-Soo (Research Center for Proteineous Materials, Chosun University) ;
  • Woo, Eun-Rhan (College of Pharmacy, Chosun University, Research Center for Proteineous Materials, Chosun University)
  • Published : 2002.10.01
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Abstract

Bioassay-directed chromatographic fractionation of a methylene chloride extract of Ailanthus altisshima indicated the presence of 20(S), 24(R), epoxy-25-hydroxydammarane-3-one (compound 1, ocotillone) which was isolated from this plant, for the first time. Antimicrobial activity of compound 1 was measured by inhibition of bacterial and fungal cells growth and by a hemolytic assay with human erythrocytes, respectively. The results revealed that compound 1 had potent antibacterial activity against Cram-negative bacteria, P. aeruginosa and S. typhimurium, that were without hemolytic activity, whereas it had weak antimicrobial activity against Gram-positive bacteria and fungi. These results demonstrated that the compound 1 has more antibacterial activity against 6ram-negative bacteria, which have no hemolytic activity, than Gram-positive bacteria and fungi. This is the first report on the biological activities of the compound 1.

Keywords

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