Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Effect of fruit extracts from Sorbus commixta Hedl. on the lipid metabolism in rats

마가목의 열매 추출물이 흰쥐의 지질대사에 미치는 영향

  • Chung, Byung-Hee (School of Biotechnology & Bioengineering, Korea Nutrition Institute, Kangwon National University) ;
  • Lee, Hyeon-Yong (School of Biotechnology & Bioengineering, Korea Nutrition Institute, Kangwon National University) ;
  • Lee, Jin-Ha (School of Biotechnology & Bioengineering, Korea Nutrition Institute, Kangwon National University) ;
  • Kim, Na-Young (Department of Food and Nutrition, Kyoung Hee University) ;
  • Lee, Sung-Yul (Laboratory Agriculture Products Processing Regional Crop Experiment Station, Kangwondo) ;
  • Choi, Jin-Tae (Green Zone Corporation) ;
  • Kim, Jae-Heun (Forest Research Institute) ;
  • Kim, Jong-Dai (School of Biotechnology & Bioengineering, Korea Nutrition Institute, Kangwon National University)
  • Published : 2003.06.30
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Abstract

This study was carried out to investigate the effect of Sorbus commixta Hedl. fruit extracts on the lipid metabolism in rats. Experimental groups were divided into 3 groups; Sprague-dawley rats were fed either diets containing 1% of water extracts(WE group), 1% methanol extracts(MeOH group) and diets without extracts(Control group) during 4 weeks. Food intake, weight gain and liver weight were not shown in meaning full difference among the groups. The concentration of serum triglyceride and total cholesterol were significantly decreased in WE and MeOH group compared to control group. Serum HDL-cholesterol, phospholipids and glucose contents were slightly lower in WE and MeOH group than control group. The levels of liver triglyceride was significantly decreased in MeOH group compared to control group. The levels of total cholesterol and phospholipids in liver were significantly lower in WE and MeOH group than control group.

Sprague-Dawley rats에 동결건조한 마가목 열매의 물과 메탄올 추출물을 식이에 1% 수준으로 첨가하여 4주간 사육한 결과, 성장률과 식이섭취량에 있어서 각 군 간에 유의적인 차이는 보이지 않았다. 혈청 중의 total cholesterol과 triglyceride 함량은 대조군에 비해, 마가목 열매의 물과 메탄올 추출물군 모두 유의적으로 감소하였다. HDL-cholesterol과 phospholipids 및 glucose는 각 군 간에 유의적인 차이가 없었다. 간장 중의 triglyceride함량을 측정한 결과, 대조군에 비해 메탄올추출물군이 유의적으로 감소하였으나 물추출물군은 통계적인 유의성이 없었다. 간장 중의 total cholesterol 함량을 측정한 결과, 물추출물군과 메탄올추출물군이 대조군에 비해 유의적으로 낮았으나 phospholipids 함량은 물추출물군과 메탄올추출물군이 대조군에 비해 약간 증가하였다. 분변량은 각 군 간에 유의적인 차이가 없었으나, 담즙산 배설은 물추출물군과 메탄올추출물군이 대조군에 비해 유의적으로 높았다.

Keywords

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