Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
권호 표지

Antitumor Activity of Peptide Fraction from Traditional Korean Soy Sauce

  • Lee, Hong-Jin (Department of Food Science ＆ Technology, School of Agricultural Biotechnology, Seoul National University) ;
  • Lee, Ki-Won (Department of Food Science ＆ Technology, School of Agricultural Biotechnology, Seoul National University) ;
  • Kim, Kyoung-Heon (Division of Food Science, College of Life and Environmental Sciences, Korea University) ;
  • Kim, Hyun-Kyung (Department of Food Science ＆ Technology, School of Agricultural Biotechnology, Seoul National University) ;
  • Lee, Hyong-Joo (Department of Food Science ＆ Technology, School of Agricultural Biotechnology, Seoul National University)
  • Published : 2004.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Antitumor activities of a peptide fraction isolated from traditional Korean soy sauce (SSP) were investigated in vitro and in vivo using cancer cell lines and F9 teratocarcinoma-bearing BALB/c mice. SSP exerted a dose-dependent antiproliferative effect on P388D1 mouse lymphoma, F9 mouse teratocarcinoma, and DLD-l human colon cancer cells with $IC_{50}$ values of 11, 50, and $50\mug/ml$, respectively. Tumor growth in F9 teratocarcinoma-bearing BALB/c mice, orally administered with 80 and 200 mg/kg/day of SSPs, was inhibited 10.3% and 52.4%, respectively, and survival days increased by 11.9% and 22.1%, respectively, compared to the control group. The results of antitumor activities exerted by SSP in vitro and in vivo suggest the feasibility of using SSP as an antitumor agent.

Keywords

References

  1. Cancer Res. v.53 Anticancer efficacy of magainin2 and analogue peptides Baker,M.A.;W.L.Maloy;M.Zasloff;L.S.Jacob
  2. Nature. v.397 RGD peptides induce apoptosis by direct caspase-3-activation Buckley,C.D.;D.Pilling;N.V.Henriquez;G.Parsonage;K.Threlfall;D.Scheel Toellner;D.L.Simmons;A.N.Akbar;J.M.Lord;M.Salmon https://doi.org/10.1038/17409
  3. J. Microbiol. Biotechnol. v.12 Antitumor activity of chitosan oligosaccharides produced in ultrafiltration membrane reactor system Jeon,Y.J.;S.K.Kim
  4. J. Microbiol. Biotechnol. v.12 Antitumor activity of Lactobacillus plantarum cytoplasm on teratocarcinoma-bearing mice Kim,J.Y.;H.J.Woo;K.H.Kim;H.J.Lee
  5. Biotechnol. Lett. v.24 Screening for antiproliferative effects of cellular components from lactic acid bacteria against human cancer cell lines Kim,J.Y.;H.J.Woo;Y.S.Kim;H.J.Lee https://doi.org/10.1023/A:1019875204323
  6. BioFactors v.12 Anticancer activity of hydrophobic peptides from soy proteins Kim,S.E.;H.H.Kim;J.Y.Kim;Y.I.Kang;H.J.Woo;H.J.Lee https://doi.org/10.1002/biof.5520120124
  7. Food Sci. Biotechnol. v.7 Cytotoxic effects of the peptides derived from traditional Korean soy sauce on tumor cell lines Kim,S.E.;T.Pai;H.J.Lee
  8. Food Sci. Biotechnol. v.12 Isolation and purification of anticancer peptides from Korean ginseng Kim,S.H.;J.Y.Kim;W.W.Park;K.W.Lee;K.H.Kim;H.J.Lee
  9. Trends Food Sci. Technol. v.3 Biochemical interactions of food-derived peptides Mills,E.N.C.;M.J.C.Alcocer;M.R.A.Morgan https://doi.org/10.1016/0924-2244(92)90132-G
  10. Cancer Res. v.52 Antitumor activity of magainin analogues against human lung cancer cell lines Ohsaki,Y.;A.F.Gazdar;H.C.Chen;B.E.Johnson
  11. J. Antibiot. v.50 Thiocoraline,a new depsipeptide with antitumor activity produced by a marine Micromonospora:Taxonomy,fermentation,isolation,and biological activities Romero,F.;F.Espliego;J.P.Baz;T.G.Quesada;D.Gravalos;F.Calle;J.L.Fernandez Puentes https://doi.org/10.7164/antibiotics.50.734
  12. J. Antibiot. v.50 GE3,a novel hexadepsipeptide antitumor antibiotic,produced by Streptomyces sp:Taxonomy,production,isolation,physico-chemical properties, and biological activities Sakai,Y.;T.Yoshida;T.Tsujita;K.Ochiai;T.Agatsuma;Y.Saitoh;F.Tanaka;T.Akiyama;S.Akinage;T.Mizukami https://doi.org/10.7164/antibiotics.50.659
  13. J. Agri. Food Chem. v.49 His-His-Leu,an angiotension Ⅰconverting enzyme inhibitory peptide derived from Korean soybean paste,exerts antihypertensive activity in vivo Shin,Z.I.;R.Yu;S.A.Park;D.K.Chung;C.W.Ahn;H.S.Nam;K.S.Kim;H.J.Lee https://doi.org/10.1021/jf001135r
  14. J. Microbiol. Biotechnol. v.10 MDP-Lys(L18),a synthetic muramyl dipeptide derivative,enhances antitumor activity of an inactivated tumor vaccine Yoo,Y.C.;S.Y.Park;K.B.Lee;I.Azuma