The Korean Journal of Physical Education (한국체육학회지)

Korean Alliance for Health: Physical Education: Recreation:and Dance (한국체육학회)
권호 표지

Effects of aerobic exercise training on acute inflanunatory markers and t-PA and cholesterol levels in obese men

유산소 트레이닝이 비만남성의 Acute Inflammatory Markers, t-PA 및 Cholesterol 농도에 미치는 영향

Yoo, Ho-Sang;Park, Sung-Han;Byun, Jae-Chul
류호상;박승한;변재철

  • Published : 2005.07.30
⟨ Previous Next ⟩

Abstract

C-reactive protein (CRP), fibrinogen, albumin, and white blood cell (WBC) counts were used as the markers for acute systemic inflammation CRP was significantly associated with obesity, high CRP level associated with increased cardiovascular disease risk. And generally, increased serum t-PA (tissue plasminogen activator) level is believed to reduce the risk of cardiovascular disease. Moreover, t-PA level may show to increase significantly after chronic exercise. The purpose of this study was to examine the effects of blood cholesterol and inflammatory markers and enhancement of systemic fibrinolytic activity after 8 weeks of aerobic exercise training. A total of 16 healthy males (n=8, control group) and obese males (n=8, experiment group) were served as subjects. Aged between 20_27 years. Subjects were assigned to a supervisor and given an exercise program 3 days a week. All subjects participated in an aerobic exercise training for 30 minutes, then did additional treadmill exercise for 30 minutes at which they were instructed to maintain a continuous 55% to 70% of the peak heart rate according to an initial exercise training. The present study showed that WBC count and serum Albumin level were no changes between groups. There were significantly different on plasma fibrinogen and serum CRP and t-PA levels between groups. Also, fibrinogen and CRP levels after aerobic exercise training were lower than pre exercise training in two groups, although serum t-PA level was e significant differences on TC level between pre and post exercise training in two groups, and HDL-C and LDL-C levels were shown to decreased. Aerobic exercise training may lowered CRP level, and there was enhanced t-PA level. In conclusion, regular physical activity may decrease the risk of cardiovascular diseases in both normal and obese men.

Keywords

References

  1. 김남익(2004). 고도 비만 여성들의 저항성 운동을 병행한 유산소운동프로그램이 신체조성 및 심전도 반응에 미치는 영향. 한국체육학회지, 제43권, 제3호, 633-644
  2. 김남익, 윤상호(2002). C-reactive protein (CRP) 농도가 고령자들의 안정시 및 운동부하 검사시 심장혈관계 질환 위험 요소에 미치는 영향. 제40회 한국체육학회 학술발표회, 629-636
  3. 김병로, 이동식(2001). 저탄수화물 식이요법과 유산소 운동이 중학교 비만학생의 체중과 혈중 지질에 미치는 영향. 한국체육학회지, 제40권, 제2호, 579-589
  4. 변재철(2003). 점진적 최대부하 운동이 마라톤 동호인의 WBC와 C-reactie protein 농도에 미치는 영향. 대한스포츠의학회지, 제22권, 제2호, 119-126
  5. 변재철(2004). 점진적 최대부하 운동이 혈중 급성염증인자와 섬유소 용해능에 미치는 영향. 한국체육학회지, 제43권, 제6호, 429-439
  6. 성은주, 신택수(2003). 한국 청소년비만이 심혈과질환 위험 인자에 미치는 영향. 가정의학회지, 제24권, 제11호, 1017-1025
  7. 이정윤, 박병근, 김광중(2004). 12주 규칙적인 에어로빅 트레이닝이 중년비만여성의 급성기염증 단백질 및 관상동맥질환위험인자에 미치는 영향. 한국체육학회지, 제43권, 제5호, 301-309
  8. 왕석우(2004). 비만유전자 변이 유, 무에 따른 12주간의 운동이 대사조절호르몬, 혈중 지질, 신체구성에 미치는 영향, 한국체육학회지, 제43권, 제3호, 699-711
  9. 장현용, 홍상완, 김봉석, 강호율(2003). 6주간의 유산소성 운동이 비만 청소년의 중 Leptin 수준에 미치는 영향. 한국체육교육학회지, 제8권, 제3호, 125-134
  10. 최희남(1992). 유산소 운동이 중년여성의 혈청지질, 체지방, 근력 및 심폐기능에 미치는 효과. 세종대학교 대학원 박사학위논문
  11. 최석준, 최태석, 이영진(2001). 10주간 달리기 운동이 비만여중생의 신체구성, 인슐린 및 렙틴 농도에 미치는 영향. 한국체육학회지, 제40권, 제2호, 759-768
  12. 탁양주, 이영성, 이진석, 강재헌(2004). 최근 국내 비만 연구의 경향: 1984년부터 2002년까지. 대한비만학회지, 제13권, 제1호, 1-13
  13. 황정숙, 이승훈, 박혜순(2003). 한국 성인 남성에서 CRP와 비만과의 연관성. 가정의학회지, 제24권, 58-63
  14. Abramson, J. L., and Vaccarino, V. (2002). Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults. Arch Intern. Med., 162, 1286-1292 https://doi.org/10.1001/archinte.162.11.1286
  15. ACSM (1995). ACSM's guidelines for exercise testing and prescription. 5th ed. Philadelphia, lippincott Williams and WIlkins
  16. Barbeau, P., litaker, M.S., Woods, K F., Lemmon, C. R., Humphries, M. C., Owens,S., &Gutin, B. (2002). Hemostatic and inflammatory markers in obese youths: effects of exercise and adiposity. J Pediatr, 141(3), 415-420 https://doi.org/10.1067/mpd.2002.127497
  17. Bullo, M., Garcia-Lorda, P., Megias, I., & SalasSalvado, J. (2003). Systemic inflammation, adipose tissue tumor necrosis factors, and leptin expression. Obes Res, 11(4), 525-531 https://doi.org/10.1038/oby.2003.74
  18. Bodary, P. F., Yausda, N., Watson, D. D., Brown, A.S., Davis, J. M. & Pate, R. R. (2003). Effects of short-term exercise training on plasminogen activator inhibitor (pAl-1). Med Sci Sports Exerc, 35:11, 1853-1858 https://doi.org/10.1249/01.MSS.0000093751.82616.F0
  19. Bumiat, W., Cole, T. J., Lissau, I., Poskitt, E. M. E. (2002). Qrild and Adolescent obesity. UK: Cambridge University Press, 3-27, 221-239
  20. Campfield, L. A., Smith, F. J. (1995). Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks? Science 269 (5223): 546-549 https://doi.org/10.1126/science.7624778
  21. Croisier, J. L., Camus, G., Venneman, I., Deby-Dupont, G., Juchmes-Ferir, A., lamy, M., Crielaard, J. M., Devy, C., & Duchateau, J. (1999). Effects of training on exercise-induced muscle damage and interleukin-6 production. Muscle & Nerve, 208-212
  22. DeSouza, C. A., Shapiro, L. F., Oevenger, C. M., Dinenno, F. A., Monahan, K D., Tanaka, H. & Seals, D. R. (2000). Regular aerobic exercise prevents and restores the age-related decline in endothelium- dependent vasodilation in healthy men. Circulation, 102, 1351-1357 https://doi.org/10.1161/01.CIR.102.12.1351
  23. Eckel, R. H. (2003). Obesity-mechanisms and clinical management. USA: Lippincott Williams & Wilkins, 3-102
  24. Geffken, D. F., Cushman, M., Benett, M, Burke, G. L., Polak, J. F., Sakkinen, P. A., and Tracy, R. P. (1996). Association between physical activity and markers of inflammation in a healthy elderly population Am J Epidemiol., 183-187
  25. Hirura, M., Kikuchi, T., Nagasaki, K., & Uchiyama, M. (2003). Hypertens Res, 26(7), 541-546 https://doi.org/10.1291/hypres.26.541
  26. Visser, M., Bouter, L. M., McWuillan, G. M., Wender, M. H., & Harris, T. B. (2001). Low-grade systemic inflammation in overweight children. Pediatrics, 107(1): E13 https://doi.org/10.1542/peds.107.1.e13
  27. Jen-Chen, T., Wen-Yin, C., Ching-Chiu, K. (2002). Beneficial effect of on blood pressure and lipid profile by programmed exercise training in Taiwanese patients with mild hypertension. Clin Exper Hypertension, 24, 315-324. https://doi.org/10.1081/CEH-120004234
  28. Jequier, E., Tappy, L. (1999). Regulation of body weight in humans? Physiol Rev, 79(2), 51-480
  29. Jerome, L. Abramson, & Vaccarino, V. (2002). Relationship between physical activity and inflammation among apparently healthy middle- aged and older US adults. Arch Int Med, 162, 1286-1292 https://doi.org/10.1001/archinte.162.11.1286
  30. Katzmarzyk, P. T., Leon, A.S., Rankinen, T., Gagnon, J., Skinner, J. S., WIlmore, J. H., Rao, D. C. & Bouchard, C. (2001). Changes in blood pressure in blood pressure consequent to aerobic exercise training related to changes in body fatness and aerobic fitness. Metabolism, 50(7), 841-848 https://doi.org/10.1053/meta.2001.24190
  31. KNHE: Korea Health Examination survey. 1998. In pres 2000
  32. Lakka, T. A. & Salonen, J. K. (1993). Moderate to high intensity conditioning leisure time physical activity and high cardiorespiratory fitness are associated with reduced plasma fibrinogen in eastern Finnish men. J Clin Epidemiol, 46, 1196-1927
  33. MacAuley, D., McCrum, E. E., and Stott, G. (1996). Physical activity, physical fitness, blood pressure, and fibrinogen in the Northern Island health and activity survey. J Epidemiol Comrnunity Health. 50, 258-263 https://doi.org/10.1136/jech.50.3.258
  34. Monkgomery, H. E., Clarkson, P., and Nwose, O. M. (1996). The acute rise in plasma fibrinogen concentration with exercise is influenced by the G453. A polymorphism of the beta fibrinogen gene. Atherscler. Thromb. Vase. Biol., 16, 386-391 https://doi.org/10.1161/01.ATV.16.3.386
  35. Pascual, M., Pascual, D. A., Soria, F., & Vicente, T. (2003). Effects of isolated obesity on systolic and diastolic left ventricular function. Heart. 89(10), 1152 https://doi.org/10.1136/heart.89.10.1152
  36. Pischon, T., Hankinson, S. E., Hotamisligil, G. S., Rifai, N., & Rimrn, E. B. (2003). Leisure- time activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res, 11(9), 1055-1064 https://doi.org/10.1038/oby.2003.145
  37. Ridker, P. M., Burning. J. E., Shih, J., Matias, M., Hennekens, C. H. (1998). Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation, 98, 731-733 https://doi.org/10.1161/01.CIR.98.8.731
  38. Saito, I., Yonemasu, K., & Inami, F. (2003). Association of body mass index, body fat, and weight gain with inflammation markers among rural residents in Japan. Circ J, 67(4), 323-329 https://doi.org/10.1253/circj.67.323
  39. Smith, D. T., Hoetzer, G. L., Greiner, J. J., Stauffer, B. L. &DeSouza, C. A. (2003). Effects of ageing and regular aerobic exercise on endothelial fibrinolytic capacity in humans. J Physiol, 1: 546, 289-298
  40. Sorichter, S., Koller, A., Haid, C. H., Wicke, K., Judrraier, W., Werner, P., & Raos, E. (1995). light concentric exercise and heavy eccentric muscle loading: effects of CK, MRI, and Markers of inflarmnation. Int J Sports Med, 16, 288-292 https://doi.org/10.1055/s-2007-973007
  41. Sprengers, E. D. & Kluft, C. (1987). Plasminogen activator inhibitor. Blood, 69, 381
  42. Sunyer, F. X. (1993). Medical hazards of obesity. Ann Intern Med, 119, 655-660 https://doi.org/10.7326/0003-4819-119-7_Part_2-199310011-00006
  43. Szymanski, L. M. & Pate, R. R. (1994). Fibrinolytic responses to moderate intensity exercise, comparision of physically active and inactive men. Thrombosis, 14, 1740-1750
  44. Upton, S. J., Hagan, R. D., & Joel, R. D. (1984). Comparative physiological profiles among young and middle-aged female distance runners. Med Sci Sports Exerc, 16(1), 67-71