Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Effects of Natural Extracts on UVB-induced Pigmentation and Inflammation in C57BL/6 Mouse Skin

천연물 도포가 UVB 파로 손상된 C57BL/6 mouse 피부의 색소침착과 염증생성에 미치는 영향

  • Choi, Wook-Hee (Department of Health Science, Dongduk Women's University) ;
  • Ann, Hyoung-Soo (College of Pharmacology, Dongduk Women's University) ;
  • Choi, Tae-Youn (Department of Clinical Pathology, College of Medicine, Soonchunhyang University) ;
  • Jin, So-Young (Department of Clinical Pathology, College of Medicine, Soonchunhyang University) ;
  • Ahn, Ryoung-Me (Department of Health Science, Dongduk Women's University)
  • 최욱희 (동덕여자대학교 보건관리학과) ;
  • 안형수 (동덕여자대학교 약학대학) ;
  • 최태윤 (순천향대학교 의과대학 임상병리학교실) ;
  • 진소영 (순천향대학교 의과대학 임상병리학교실) ;
  • 안령미 (동덕여자대학교 보건관리학과)
  • Published : 2006.10.31
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Abstract

Ultraviolet(UV) radiation causes a variety of biological effects on the skin, including inflammation, pigmentation, photoaging and cancer. Free radicals are involved in inflammatory skin reactions induced by UVB radiation. In this study, we investigated the effects of antioxidants(Tea, Korean red ginseng, Ginkgo biloba extract) on UVB-induced skin damage. Tea, KRG and EGb 761 were topically treated to dorsal skin of ICR mouse. The mice were also treated soon after IMED ($1.4KJ/m^{2}$) of UVB irradiation. Skin pigmentation of irradiated mouse was observed by a chromameter after 2 weeks. Topical application of Tea, KRG and EGb 761 for 2 weeks decreased skin pigmentation compared to DVB control group(p<.05). Tea, KRG and EGb 761 also reduced UVB-induced infiltration of inflammatory cells. These results showed that Tea, KRG and EGb 761 as a topical application may have preventive effect against UVB-induced skin damage.

Keywords

References

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