Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Development of Biologically Active Compounds from Edible Plant Sources-XXIV. - Anti-cancer Activity of Alcohol Extracts from Edible Plants -

식용 식물자원으로부터 활성물질의 탐색-XXIV. - 식용 식물 추출물의 항암 활성 -

  • Kwak, Ho-Young (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Kwon, Byoung-Mog (Korea Research Institute of Bioscience and Biotechnology) ;
  • Song, Myoung-Chong (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Lee, Jin-Hee (Seoul Pharma Laboratories) ;
  • Yang, Hye-Joung (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University) ;
  • Kim, Dae-Keun (Department of Pharmacy, Woosuk University) ;
  • Ahn, Eun-Mi (Department of Oriental Medicine Biofood Science, Daegu Hanny University) ;
  • Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University)
  • 곽호영 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 권병목 (한국생명공학연구원) ;
  • 송명종 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 이진희 (서울의약연구소) ;
  • 양혜정 (경희대학교 생명공학원 및 식물대사연구센터) ;
  • 김대근 (우석대학교 약학대학) ;
  • 안은미 (대구한의대학교 한방식품약리학과) ;
  • 백남인 (경희대학교 생명공학원 및 식물대사연구센터)
  • Published : 2007.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

The screening of anti-cancer activity for the MeOH extracts of 163 natural sources, which were registered as edible plants by Korea Food & Drug Administration, exhibited 9 extracts to have significant inhibitory effects on farnesyl-protein transferase (FPTase) and phosphatase of regenerating liver-3 (PRL-3). In order to confirm the inhibitory activity of these active extracts, the activity assay was repeated for some fractions obtained from the active extracts using Medium Pressure Liquid Chromatography (MPLC). Some fractions of Carya illinoensis, Chlorella vulgaris, Panicum miliaceum, Perilla frutescens, Rosmarinus officinalis showed over 50% inhibitory activity on FPTase as well as those of Capsella bursa-pastoris, C. illinoensis, C. vulgaris, Coix lacrymajobi, Myristica fragrans, P. miliaceum, R. officinalis did over 50% inhibitory activity on PRL-3.

Keywords

References

  1. Folkman, J. (2002) Role of angiogenesis in tumor growth and matastasis. Semin Oncol. 29: 15-18
  2. Doll, R. and Peto, R. (1981) The causes of cancer. J. Natl. Cancer Inst. 66: 1191-1308
  3. Wakabayashi, K., Nagao, M., Esumi, H. and Sugimura, T. (1992) Food-derived mutagens and carcinogens. Cancer Res. 52: 2092-2098
  4. Kellof, G. J., Boone, C. W. and Crowell, J. A. (1994) Chemopreventive drug development: perspectives and progress. Cancer Epidemiol. Biomarkers Prev. 3: 85-88
  5. Clifford, C. and Kramer, B. (1993) Diet as risk and therapy for cancer. Med. Clin. North Am. 77: 725-744 https://doi.org/10.1016/S0025-7125(16)30220-6
  6. Bos, J. L. (1989) Ras oncogenes in human cancer. Cancer Res. 49: 4682-4689
  7. Feramisco, J. R., Gross, M., Kamata, T., Rosenberg, M. and Sweet, R. W. (1984) Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells. Cell 38: 109-117 https://doi.org/10.1016/0092-8674(84)90531-2
  8. Kim, H., Suh, J. M., Hwang, E. S., Kim, D. W., Chung, H. K., Song, J. H., Hwang, J. H., Park, K. C., Ro, H. K., Jo, E. K., Chang, J. S., Lee, T. H., Lee, M. S., Kohn, L. D. and Shong, M. (2003) Thyrotropin-mediated repression of class II trans-activator expression in thyroid cells: involvement of STAT3 and suppressor of cytokine signaling. J. Immunol. 171: 616-627 https://doi.org/10.4049/jimmunol.171.2.616
  9. Kisseleva, T., Bhattacharya, S., Braunstein, J. and Schindler, C. W. (2002) Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285: 1-24 https://doi.org/10.1016/S0378-1119(02)00398-0
  10. Kortylewski, M., Kujawski, M. and Wang, T. (2005) Inhibiting STAT3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat. Med. 11: 1314-1321 https://doi.org/10.1038/nm1325
  11. Polato, F., Codegoni, A., Fruscio, R., Perego, P., Mangioni, C., Saha, S., Bardelli, A. and Broggini, M. (2005) PRL-3 phosphatase is implicated in ovarian cancer growth. Clin. Cancer Res. 11: 6835-6839 https://doi.org/10.1158/1078-0432.CCR-04-2357
  12. Wesierska-Gadek, J., Maurer, M. and Schmid, G. (2007) Inhibition of farnesyl protein transferase sensitizes human MCF-7 breast cancer cells to roscovitine-mediated cell cycle arrest. J. Cell. Biochem. 102: 736-747 https://doi.org/10.1002/jcb.21325
  13. Germain, D. and Frank, D. (2007) Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin. Cancer Res. 13: 5665-5669 https://doi.org/10.1158/1078-0432.CCR-06-2491
  14. Li, Z., Zhan, W., Wang, Z., Zhu, B., He, Y., Peng, J., Cai, S. and Ma, J. (2006) Inhibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peritoneal metastasis. Biochem. Bioph. Res. Co. 348: 229-237 https://doi.org/10.1016/j.bbrc.2006.07.043
  15. Oh, H. M., Kwon, B.-M., Baek, N.-I., Kim, S.-H., Lee, J. H., Eun, J. S., Yang, J. H. and Kim, D. K. (2006) Inhibitory activity of 6-O-angeloylprenolin from Centipeda minima on farnesyl protein transferase. Arch. Pharm. Res. 29: 64-66 https://doi.org/10.1007/BF02977470
  16. Kim, S. S., Park, M. K., Oh, N. S., Kim, D. C., Han, M. S. and In, M. J. (2003) Studies of quality characteristics and shelf-life of chlorella soybean (Tofu). Kor. J. Soc. Agric. Chem. Biotechnol. 46: 12-15
  17. Singh, A., Singh, S. P. and Bamezai, R. (1998) Perinatal influence of Chlorella vulgaris (E-25) on hepatic drug metabolizing enzymes and lipid peroxidation. Anticancer Res. 18: 1509-1514
  18. Morimoto, T., Nagatsu, A., Murkami, N., Sakakibara, J., Tokuda, H., Nishino, H. and Iwashima, A. (1995) Antitumor- promoting glyceroglycolipids from the green alga, Chlorella vulgaris. Phytochemistry. 40: 1433-1437 https://doi.org/10.1016/0031-9422(95)00458-J
  19. Hasegawa, T., Ito, K., Kumamoto, S., Ando, Y., Yamada, A., Nomoto, K. and Yasunobu, Y. (1999) Oral administration of a hot water extracts of Chlorella vulgaris reduces IgE production against milk casein in mice. Int. J. Immunophamacol. 21: 311-323 https://doi.org/10.1016/S0192-0561(99)00013-2
  20. Chung, S., Cho, S., Lee, H., Kim, G. and Ha, T. (1998) Effect of millet powder and methanol extract on lipid synthesisrelated enzymes or glucose-6-phosphatase activity in rats. P- 2 Poster session in Annual meeting, J. Kor. Soc. Food Sci. Nutr
  21. Ibanez, E., Cifuentes, A., Crego, A. L., Senorans, F. J., Cavero, S. and Reglero, G. (2000) Combined use of supercritical fluid extraction, micellar electrokinetic chromatography, and reverse phase high performance liquid chromatography for the analysis of antioxidants from rosemary (Rosmarinus officinalis L.). J. Agric. Food Chem. 48: 4060-4065 https://doi.org/10.1021/jf0002692