Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Immune Activities of Rhodiola sachalinensis A. Bor Extracts Isolated with Various Extraction Process

추출조건에 따른 참돌꽃의 면역 활성

  • Kim, Cheol-Hee (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Kwon, Min-Chul (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Han, Jae-Gun (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Ha, Ji-Hye (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Jeong, Hyang-Suk (College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Choi, Geun-Pyo (Department of Food Processing & Bakery, Gangwon Provincial Univ.) ;
  • Park, Uk-Yeon (Department of Food Processing & Bakery, Gangwon Provincial Univ.) ;
  • Nam, Jong-Hyun (Grami Co., Ltd.) ;
  • Hwang, Baik (Department of Biology, Chonnam National Univ.) ;
  • Lee, Hyeon-Yong (College of Bioscience & Biotechnology, Kangwon National Univ.)
  • 김철희 (강원대학교 BT특성화학부대학) ;
  • 권민철 (강원대학교 BT특성화학부대학) ;
  • 한재건 (강원대학교 BT특성화학부대학) ;
  • 하지혜 (강원대학교 BT특성화학부대학) ;
  • 정향숙 (강원대학교 BT특성화학부대학) ;
  • 최근표 (강원도립대학 식품가공제과제빵과) ;
  • 박욱연 (강원도립대학 식품가공제과제빵과) ;
  • 남종현 ((주)그래미) ;
  • 황백 (전남대학교 생물학과) ;
  • 이현용 (강원대학교 BT특성화학부대학)
  • Published : 2008.12.30
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Abstract

This study was performed to compare effect of immune activities of Rhodiola sachalinensis by various extraction process with different temperature and extraction solvents. Experiments were performed for investigate the immune activities on human B and T cell growth and secretion of their cytokines. Also, antibodies in serum were investigated in female ICR mouse by feeding the extracts of R. sachalinensis at doses of 40, 120 and 360 mg/kg orally for 15 days. The immune cell growth and secretion of cytokines (IL-6, TNF-$\alpha$) on human B and T cells were increased by adding R. sachalinensis extracts compare to the control. Also, total serum IgG levels increased by feeding R. sachalinensis extracts. It can be conclude that optimum condition for efficient extraction of R. sachalinensis as functional material is slovent extraction process using water with ultrasonification at below $100^{\circ}C$ than typical process.

Keywords

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