Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
권호 표지

Effect of Immune Activity on Berberis koreana Palibin by Ultra High Pressure Low Temperature Process

초고압 저온처리에 의한 매자나무의 면역 활성

  • Jin, Ling (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Han, Jae-Gun (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Ha, Ji-Hye (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Jeong, Hyang-Suk (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Kwon, Min-Chul (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Ahn, Ju-Hee (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Kim, Jin-Chul (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Choi, Geun-Pyo (Department of Food Processing and Bakery, Gangwon Provincial College) ;
  • Chung, Eul-Kwon (Myung Jin Farm Co.) ;
  • Lee, Hyeon-Yong (College of Bioscience and Biotechnology, Kangwon National University)
  • 김영 (강원대학교 BT특성화학부대학) ;
  • 한재건 (강원대학교 BT특성화학부대학) ;
  • 하지혜 (강원대학교 BT특성화학부대학) ;
  • 정향숙 (강원대학교 BT특성화학부대학) ;
  • 권민철 (강원대학교 BT특성화학부대학) ;
  • 안주희 (강원대학교 BT특성화학부대학) ;
  • 김진철 (강원대학교 BT특성화학부대학) ;
  • 최근표 (강원도립대학 식품가공제과제빵과) ;
  • 정을권 (명진농장) ;
  • 이현용 (강원대학교 BT특성화학부대학)
  • Published : 2008.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

This study was performed to investigate a methodology of improving immune activities of Berberis koreana Palibin by ultra high pressure on low temperature extraction process. Extraction yield was enhanced up to more than 35% by above process, compare to the control and extraction average. The cytotoxicity on human kidney cell (HEK293) was showed below 20.4%, 21.6% in adding 1.0 mg/ml of the highest concentration. Generally, the extracts by ultra high pressure extraction process showed less toxicity about 5% than the other processes. It could tell that toxic materials that existing in the plant could be reduced or broken by ultra high pressure process due to can be broken bond such the hydrogen bond, the electrostatic bond, the van der Waals bond, and the hydrophobic bond, can be broken by high pressure. The result could be employed to develop a new type of functional food from B. koreana Palibin by low temperature high pressure process.

Keywords

References

  1. Doll R and Peto R. (1981). The causes of cancer : quantitative estimates of avoidable risks of cancer in the United States today. Journal of the National Cancer Institute. 66:1191-1308
  2. Han BH, Park MH, Cho JY, Park JS, Yoo ES and Baik KU. (1998). Effect of Ginsenosides from Panax ginseng on TNF-$\alpha$ production and T cell proliferation. Yakhak Hoeji. 42:296-301
  3. Hermans K. (2003). Pressure and temperature induced phenomena in proteins. 3-8. In Winter R. (ed.) Advances in high pressure bioscience and biotechnology II. Springer-Verlag, Berlin, Germany
  4. Kim CH, Kwon MC, Han JG, Na CS, Kwak HG, Choi GP, Park UY and Lee HY. (2008). Skin-whitening and UV-protective effects of Angelica gigas Nakai extracts on ultra high pressure extraction process. Korean Journal of Medicinal Crop Science. 16:255-260
  5. Kim CH, Kwon MC, Qadir SA, Hwang B, Nam JH and Lee HY. (2007). Toxicity reduction and improvement of anticancer activies from Rhodiola sachalinensis A. Bor by ultra high pressure extracts process. Korean Journal of Medicinal Crop Science. 15:411-416
  6. Lee YG and Cho JY. (2007). Inhibition effect of curcumin on nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells and its suppressive mechanism. Korean Journal of Medicinal Crop Science. 15:451-456
  7. Park JH, Lee HS, Mun HC, Kim DH, Seong NS, Jung HG, Bang JK and Lee HY. (2004). Effect of ultrasonification process on enhancement of immuno-stimulatory activity of Ephedra sinica Stapf and Rubus coreanus Miq. Korean Journal of Biotechnology and Bioengineering. 19:113-117
  8. Yueran Z, Rui S, You L, Chunyi G and Zhigang T. (2003). Expression of leptin receptors and response to leptin stimulation of human natural killer cell lines. Biochemical and Biophysical Research Communications. 300:247-252 https://doi.org/10.1016/S0006-291X(02)02838-3
  9. Zhang S, Zhu J and Wang C. (2004). Novel high pressure extraction technology. International Journal of Pharmaceutics. 278:471-474 https://doi.org/10.1016/j.ijpharm.2004.02.029