Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Antioxidative and Antitumor Activity of Extracts from Saussurea lappa

목향 추출물의 항산화 및 항암활성

  • Song, Jin-Wook (Department of Public Health Graduate School Keimyung University) ;
  • Min, Kyung-Jin (Department of Public Health Graduate School Keimyung University) ;
  • Cha, Chun-Geun (The Center for Traditional Microorganism Resources, Keimyung University)
  • 송진욱 (계명대학교 자연과학대학 공중보건학과) ;
  • 민경진 (계명대학교 자연과학대학 공중보건학과) ;
  • 차춘근 (전통미생물 자원개발 및 산업화연구센터)
  • Published : 2008.02.28
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Abstract

This study was carried out to investigate the antioxidative and antitumor activities of Saussurea lappa for the purpose of developing a functional food. The methanol extract of Saussurea lappa was fractionated with five solvents (hexane, chloroform, EtOAc, BuOH, water) and examined for antioxidative activities and xanthine oxidase inhibitory activity in addition to growth inhibitory activity of human cancer cell (HT-29, SNU-1, HeLa). Total phenol compound contents were higher in EtOAC fraction than other fractions. Also, electron donating ability was over 90% at $500{\mu}g/ml$ (93.1 %) and $1000{\mu}g/ml$ (94.3%). The hexane fraction revealed stronger nitrite scavenging ability than the positive control (ascorbic acid) and its abilities were 22.4% and 42.8% at $500{\mu}g/ml$ and $1000{\mu}g/ml$, respectively. Xanthine oxidase inhibitory activity had similar tendency to electron donating ability. The EtOAc fraction showed high inhibition to xanthien oxidase activities at $500{\mu}g/ml$(81.9%) and $1000{\mu}g/ml$(90.4%). In the antitumor activity test, the hexane fraction exhibited potent growth inhibition activity against HT-29, SNU-1 and HeLa cells. Therefore, we believe that Saussurea lappa can be developed into a functional food with antioxidant activity. Additional studies are required for the hexane and chloroform fractions of Saussurea lappa to develop them into therapeutic supplements for stomach cancer, colon cancer, and cervical cancer.

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References

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