Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
권호 표지
DOI QR코드

DOI QR Code

The Anti-hepatotoxic Effect of Ginseng in Rats: Meta-analysis

  • Kook, Se-Jeong (Plant Resources Research institute, Duksung Women's University) ;
  • Han, Hye-Kyoung (Plant Resources Research institute, Department of Food and Nutrition, Duksung Women's University) ;
  • Kim, Gun-Hee (Plant Resources Research institute, Department of Food and Nutrition, Duksung Women's University) ;
  • Choi, Ki-Heon (Department of Statistics, Duksung Womens University)
  • Published : 2008.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

The aim of this meta-analysis was to systematically investigate the anti-hepatotoxic effect of ginseng in rats induced toxicity which damage to liver. Primary researches were gained on the ScienceDirect database, the DBpia, and the KISS, and the data about the effect factors in plasma and in enzyme were listed as many as possible. The effect factors were alanine transaminase (ALT), aspartate transaminase (AST), liver aminopyrine N-demethylase (AD), liver aniline hydroxylase (AH), liver 3,4-Methylenedioxyamphetamine (liver MDA), cytochrome P450 (P450), serum alkaline phosphatase (ALP), serum lactate dehydrogenase (LDH), cytochrome b5 (Cyto b5), glutathione reductase (GR), Liver glutathione S-transferase (GST), liver glutamyltransferase (GT), Liver (${\gamma}-GCS$), serum liver 3,4-Methylenedioxyamphetamine (serum MDA), serum sorbitol dehydrogenase (SDH), serum total protein (TP), serum ${\gamma}-glutamyltransferase$ (${\gamma}-GT$). To investigate the effect of ginseng, the mean difference (MD) between the group of rats induced by toxicity (RH) and the group of rats induced by toxicity with ginseng (RHG) were combined, and the significance of MDs were tested. The combined MDs were checked the biases caused by heterogeneity among studies and the publication biases, and adjusted by using random effect model and trim and fill method, respectively. The effect about ALT, AST, ALP, LDH, SDH, TP and ${\gamma}-GT$ in plasma factors were significant, and about AD, liver MDA, P450, Cyto b5, GR, GST, GT and ${\gamma}-GCS$ in enzyme factors were significant. The treatment with ginseng supplementation was significantly effected on plasma and enzyme factors of damaged-rats.

Keywords

References

  1. Lee, W. M. : Drug-induced hepatotoxicity. N Engl J Med. 349, 474-485 (2003) https://doi.org/10.1056/NEJMra021844
  2. Nilesh Mehta, and Lisa Ozick. : Drug-Induced Hepatotoxicity. http://www.emedicine.com/Med/topic3718.htm
  3. Cupp, M. J. : Herbal remedies: adverse effects and drug interactions. Am Fam Physician 59, 1239-1244 (1999)
  4. De Smet PAGM, Keller, K., Hansel, R. and Chandler, R. F. eds. : Adverse effects of herbal drugs. Berlin, Germany: Springer - Verlag (1997)
  5. Kiefer, D. and Pantuso, T. : Panax ginseng. American Academy of Family Physicians 68, 1539-1542 (2003)
  6. Health Organization. WHO monographs on selected medicinal plants. Geneva: World Health Organization (1999)
  7. Han, K., Shin, I. C., Choi, K. J., Yun, Y. P., Hong, J. T. and Oh, K. W. : Korea red ginseng water extract increases nitric oxide concentrations in exhaled breath. Nitric Oxide. 2005 May; 12(3), 159-162 https://doi.org/10.1016/j.niox.2005.02.001
  8. Choi, K. and Kook, S. : What is the meta-analysis?. Meta-analysis using program MIX. FreeAcademy, Seoul, Korea. pp. 2-4 (2007)
  9. Sutton, A., Abrams, K., Jones, D., Sheldon, T. and Song, F. : Introduction, Publication bias. In Methods for Meta-Analysis in Medical Research. Wiley. pp. 3-13, 117-119 (2000)
  10. Kim, S. Y., Kim, Y. C., Byun, S. J., Kim, E. : The effect of Ginsenosides on Galactosamine-induced Hepatotxicity, Kor. J. Pharmacogn., 22(4), 219-224 (1991)
  11. Kwak, Y. S., Kyung, J. S., Song, Y. B., Wee, J. J., Prak, J. D. : Effect of Crude saponine from Red-ginseng effluex on Blood biochemical parameters in Rats Acutely Exposed to 2,3,7,8-tetrachlorodibenzo-ρ-dioxin(TCDD), J. Ginseng Res., 30(1), 8-14 (2006) https://doi.org/10.5142/JGR.2006.30.1.008
  12. Lee, J. K., Han, Y. N., Kim, N. Y., Choi, J. W. : The Therapeutic Effects of Korean Red Ginseng on Carbon Tetrachloride and Galactosamine-induced Hepatotoxicity in Rats, J. Ginseng Res., 27(1), 11-16 (2003) https://doi.org/10.5142/JGR.2003.27.1.011
  13. Lee, J. K., Kim, N. Y., Han, Y. N. and Choi, J. W. : Effects of Pretreated Korean Red Ginseng on Carbon Tetrachloride and Galactosamine-induceed Hepatotoxicity in Rats, J. Ginseng Res., 27(1), 1-10 (2003) https://doi.org/10.5142/JGR.2003.27.1.001
  14. Lee, J. K., Choi, J. W., Kim, S. H., Kim, H. K. and Han, Y. N. : Biological Activities of Acidic Polysaccharide of Korean Red Ginseng.III.-Effects on Metabolizing Activities in Acetaminophen-treated Rats, J. Ginseng Res., 22(4), 267-273 (1998)
  15. Wee, J. J., Heo, J. N., Kim, M. W. and Kang, D. Y. : Protective Effect of Korean Red Ginseng against Oxidative Damage by Carbon Tetrachloride in Rat, Korean J. Ginseng Sci., 20(2), 154-158 (1996)
  16. Song, K. H., Kim, D. H., Choi, K. J. : The effect of Aquaacupuncture of Total Saponin on the Damaged Liver Induced by Carbon Tetrachloride in Rats, Korean J. Vet Clin Med, 13(2), 108-113 (1996)
  17. Kim, H. Y., Lee, Y. H. and Kim, S. I. : Antihepatotoxic Components of Korean Ginseng: Effect on Lipid Peroxidation, Korean Biochem. J., 22(1), 12-18 (1989)
  18. Kim, Y. S. : Protective Effect of Ginseng Polysacchride Fraction on $CCl_4$-induced Hepatotoxcity in vitro and in vivo, Korean J. Ginseng Sci., 19(2), 108-113 (1995)
  19. Ha, B. J. : Effects of Rhynchosia molubilis Saponine on Hpatotoxicity and Pathology, Journal of Life Science, 16(2), 186-191 (2006) https://doi.org/10.5352/JLS.2006.16.2.186
  20. Sutton, A., Abrams, K., Jones, D., Sheldon, T. and Song, F. : Methods for Meta-Analysis in Medical Research. Wiley (2000)
  21. Whiteead, A. Meta- Analysis of Controlled Clinical Trials. John Wiley & Sons (2002)