Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Suppression of Osteoporotic bone loss on the site to which low Intensity Ultrasound is Irradiated - In vivo test on BMD and Morphological Characteristics

저강도 초음파 조사 부위의 골 소실 억제 효과 -골 밀도 및 형태학적 특성 평가

  • Ko, Chang-Yong (Department of Biomedical Engineering and & Institute of Medical Engineering, Yonsei University) ;
  • Seo, Dong-Hyun (Department of Biomedical Engineering and & Institute of Medical Engineering, Yonsei University) ;
  • Kim, Hyo-Seon (Department of Biomedical Engineering and & Institute of Medical Engineering, Yonsei University) ;
  • Kim, Han-Sung (Department of Biomedical Engineering and & Institute of Medical Engineering, Yonsei University) ;
  • Kim, Sang-Hee (Electronics and Telecommunications Research Institute) ;
  • Kim, Jin-Man (Chungnam National University) ;
  • Kim, Ki-Won (Department of Biomedical Engineering and & Institute of Medical Engineering, Yonsei University) ;
  • Lim, Do-Hyung (Musetec)
  • 고창용 (연세대학교 의공학과 & 의료공학연구원) ;
  • 서동현 (연세대학교 의공학과 & 의료공학연구원) ;
  • 김효선 (연세대학교 의공학과 & 의료공학연구원) ;
  • 김한성 (연세대학교 의공학과 & 의료공학연구원) ;
  • 김상희 (한국전자통신연구원) ;
  • 김진만 (충남대학교 의과학대) ;
  • 김기원 (뮤즈텍) ;
  • 임도형 (연세대학교 의공학과 & 의료공학연구원)
  • Published : 2009.02.28
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Abstract

Purpose : The aim of this study is to evaluate a possibility of clinical application for the effects of low intensity ultrasound stimulation (LIUS) in morphological characteristics (i.e., structure, bone mineral density) of bone on osteoporotic fracturesprevention. Materials and Methods : Eight virgin 14-week-old ICR mice (approximate weight 25g) were used and ovariectomized (OVX) to induce osteoporosis. Right tibia (US) for each mouse served as the LIUS (1.5MHz frequency, 1.0 kHz pulse repetition on frequency, $30mW/cm^2$ intensity, $200{\mu}s$ pulse length, and stimulation for 20 minutes a day and 5 days a week over a 6-week period). Left tibia (CON) for each mouse served as the non-stimulated controls. Structural parameters and bone mineral density ($g/cm^3$) on trabecular bone of tibiae were calculated and measured from images derived in-vivo micro computed tomography (micro-CT) at 0 week and after 6weeks. Results : The BV/TV and Tb.N in US group were significantly bigger than those in CON group. The Tb.Pf in US group, moreover, was significantly smaller than that in CON group (p<0.05).For the others structural parameters and BMD, however, there were no significant difference between US group and CON group (p>0.05). Conclusion : The LIUS might prevent bone loss and keep bone connectivity in osteoporotic bones. Therefore, the LIUS might prevent effectively the osteoporotic fractures in clinics.

Keywords

References

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