Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Slow Development of Diabetic Cataract in Streptozotocin-induced Diabetic Rats via Inhibition of Aldose Reductase Activity and Sorbitol Accumulation by Use of Aster koraiensis Extract

알도즈 환원효소 활성억제와 소비톨 축적 억제로 인한 벌개미취 추출물의 당뇨병성 백내장 발병 지연 효능

  • Kim, Chan-Sik (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM)) ;
  • Kim, Jung-Hyun (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM)) ;
  • Jeong, Il-Ha (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM)) ;
  • Kim, Young-Sook (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM)) ;
  • Lee, Jun (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM)) ;
  • Jang, Dae-Sik (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM)) ;
  • Kim, Jin-Sook (Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM))
  • 김찬식 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터) ;
  • 김정현 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터) ;
  • 정일하 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터) ;
  • 김영숙 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터) ;
  • 이준 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터) ;
  • 장대식 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터) ;
  • 김진숙 (한국한의학연구원 한의융합연구본부 당뇨합병증연구센터)
  • Published : 2009.12.31
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Abstract

Diabetic cataract is a major complication of diabetes mellitus. Excess accumulation of sorbitol plays an important role in the pathogenesis of diabetic complications such as cataract formation. In this study, we investigated the inhibitory effect of the extract of the aerial parts of Aster koraiensis (AK) on diabetic cataractogenesis. To examine this further, we evaluated sorbitol accumulation during cataract development using streptozotocin-induced diabetic rat, an animal model of type 1 diabetes. Diabetic rats were treated orally with AK (100 mg/kg and 200 mg/kg body weight) once a day orally for 9 weeks. In vehicle-treated diabetic rats, lens opacity was increased, and lens fiber swelling and membrane rupture were observed. In addition, sorbitol accumulation in diabetic lens was markedly enhanced. However, AK treatment delayed the progression of diabetic cataract through the inhibition of sorbitol accumulation, and prevented lens fiber degeneration in a dose-dependent manner. These observations suggest that AK treatment can delay the progression of lens opacification in the diabetic rats during the early diabetic cataractogenesis.

Keywords

References

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