The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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The effect of Elastase inhibition and Tyrosinase by Rheum undulatum Stokes extracts

대황(大黃)의 Elastase 활성 억제와 Tyrosinase 억제연구

  • 이종철 (경원대학교 한의과대학 안이비인후피부과학 교실) ;
  • 김경준 (경원대학교 한의과대학 안이비인후피부과학 교실)
  • Received : 2009.10.31
  • Accepted : 2009.12.05
  • Published : 2009.12.25
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Abstract

Objective : Recently, the demands for the effective and safe depigmentating and anti-aging agents of the skin have increased due to the medical, pharmaceutical and cosmetic reasons. The aim of this study is to search new materials from the traditional herbal medicines which inhibit the aging process of skin in vitro. Methods : herbal medicines(80% ethanol or water extracts) were screened for their inhibitory activities against elastase. Results : Rheum undulatum (final concentrstion 1 mg/ml) appeared over 30% of inhibition of elastase activity. so we are investigated anti wrinkle effects of Rheum undulatum look through MMP-1 inhibition activity. also Extracts of Rheum undulatum showed higher anti tyrosinase activity than arbutin (final concentration 1 mg/ml). Conclusion : These results suggest that herbal medicines could be strong potential sources of inhibition of anti-aging and whitening effects for the skin.

Keywords

References

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