Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
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The Anticancer Effects and Drug Metabolic Enzyme Change by Oral Intake of Agrimonia Pilosa Ledeb

선학초(짚신나물) 경구투여시 항암효과 탐색 및 약물 대사효소의 변화

  • Rhee, Si-Hyung (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Jung, Hee (Department of preventivie Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Ju-Ah (Department of Oriental Internal Medicine, College of Oriental Medicine, Semyung University) ;
  • Go, Ho-Yeon (Department of Oriental Internal Medicine, College of Oriental Medicine, Semyung University) ;
  • Choi, Yu-Kyung (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Park, Jong-Hyung (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Kim, Ji-Hye (Department of preventivie Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Ko, Seong-Kyu (Department of preventivie Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Jun, Chan-Yong (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyungwon University)
  • 이시형 (경원대학교 한의과대학 내과학교실) ;
  • 정희 (경희대학교 한의과대학 예방의학교실) ;
  • 이주아 (세명대학교 한의과대학 내과학교실) ;
  • 고호연 (세명대학교 한의과대학 내과학교실) ;
  • 최유경 (경원대학교 한의과대학 내과학교실) ;
  • 박종형 (경원대학교 한의과대학 내과학교실) ;
  • 김지혜 (경희대학교 한의과대학 예방의학교실) ;
  • 고성규 (경희대학교 한의과대학 예방의학교실) ;
  • 전찬용 (경원대학교 한의과대학 내과학교실)
  • Received : 2009.07.02
  • Accepted : 2009.08.10
  • Published : 2009.08.30
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Abstract

Objective : This research was aimed to investigate the anti-tumor effect, safety, mechanism and metabolizing enzyme of Agrimonia pilosa LEDEB(APL) in female C57B/L mouse. Methods : At first, to evaluate the anti-tumor activity of APL, we divided into four groups, normal, control, APL100(100mg/kg), APL150(150mg/kg). LLC obtained American Type Culture Collection was used. LLC had been inoculated to induce tumor. To measure the anti-tumor effect of APL, we calibrate tumor size and weight. To study for mechanism of anti-tumor in APL, we used western blotting and to know metabolizing enzyme in APL we used to real-time PCR. Results : APL100, APL150 inhibited tumor growth after medicine injected. APL did not only induced caspase-dependent apoptosis in LLC-bearing mouse tumor. In APL100, it were decreased 72% in CYP3A11. In APL150, it were decreased 62%, 75% in CYP3A11 and MRP1a respectively. Conclusion : These results suggests that APL has some anti-tumor effects in female C57B/L mouse tumor. APL should be careful use with other drugs related with CYP3A11 or MRP1a.

Keywords

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