Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Comparison of Biological Activities of Fermented Codonopsis lanceolata and Fresh Codonopsis lanceolata

생더덕과 발효더덕의 유용생리활성 비교

  • Kim, Seung-Seop (Department of Biomaterials Engineering, College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Ha, Ji-Hye (Department of Biomaterials Engineering, College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Jeong, Myoung-Hoon (Department of Biomaterials Engineering, College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Ahn, Ju-Hee (Department of Biomaterials Engineering, College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Yoon, Won-Byung (Department of Food Science and Biotechnology, College of Bioscience & Biotechnology, Kangwon National Univ.) ;
  • Park, Sung-Jin (Department of Tourism Food Service Cuisine, Hallym College) ;
  • Seong, Dong-Ho (Yooyoung Pharmaceutical Co.) ;
  • Lee, Hyeon-Yong (Department of Biomaterials Engineering, College of Bioscience & Biotechnology, Kangwon National Univ.)
  • 김승섭 (강원대학교 BT특성화학부대학 생물소재공학과) ;
  • 하지혜 (강원대학교 BT특성화학부대학 생물소재공학과) ;
  • 정명훈 (강원대학교 BT특성화학부대학 생물소재공학과) ;
  • 안주희 (강원대학교 BT특성화학부대학 생물소재공학과) ;
  • 윤원병 (강원대학교 BT특성화학부대학 식품생명공학과) ;
  • 박성진 (한림성심대학 관광외식조리과) ;
  • 성동호 ((주)유영제약) ;
  • 이현용 (강원대학교 BT특성화학부대학 생물소재공학과)
  • Published : 2009.08.30
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Abstract

Both fresh Codonopsis lanceolata and lactic acid bacteria fermented Codonopsis lanceolata were extracted with water at $100^{\circ}C$, and tested for anticancer activity using several human cancer cell lines. The fermented extracts inhibited the growth of hepatocellular carcinoma cells up to 90%, compared to 75% for fresh Codonopsis lanceolata. The extracts of cytotoxicity on human normal lung cells (HEK293) were as low as 15%. Especially, human hepatocellular carcinoma cell were more efficiently inhibited than other cells. This extract also inhibited $\alpha$-glucosidase activity up to 60% at 1.0mg/$m{\ell}$. This fermented extracts showed the inhibition potency on tyrosinase by 25% at 1.0mg/$m{\ell}$. From the results, the fermented Codonopsis lanceolata enhanced several biological activities up to $20{\sim}30%$, compared to those from fresh Codonopsis lanceolata. It implies that fermentation process could be one of useful methods of utilizing low quality Codonopsis lanceolata. Because this process could yield high amounts of biologically active compounds by the help of microbial growth.

Keywords

References

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