Mycobiology

The Korean Society of Mycology (한국균학회)
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The Anti-inflammatory Effects of Water Extract from Cordyceps militaris in Murine Macrophage

  • Jo, Wol-Soon (Department of Microbiology, Dong-A University College of Medicine) ;
  • Choi, Yoo-Jin (Department of Microbiology, Dong-A University College of Medicine) ;
  • Kim, Hyoun-Ji (Department of Microbiology, Dong-A University College of Medicine) ;
  • Lee, Jae-Yun (Cheong-Won Farm) ;
  • Nam, Byung-Hyouk (Deartment of Microbiology, Pusan National University College of Natural Sciences) ;
  • Lee, Jae-Dong (Deartment of Microbiology, Pusan National University College of Natural Sciences) ;
  • Lee, Sang-Wha (Department of Microbiology, Dong-A University College of Medicine) ;
  • Seo, Su-Yeong (Department of Microbiology, Dong-A University College of Medicine) ;
  • Jeong, Min-Ho (Department of Microbiology, Dong-A University College of Medicine)
  • Published : 2010.03.31
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Abstract

The aim of this study was to determine the in vitro anti-inflammatory effect of hot water extract from Cordyceps militaris fruiting bodies (CMWE) on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production, tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and interleukin-6 (IL-6) release in RAW 264.7 cells. The treatment of macrophages with various concentrations of hot CMWE significantly reduced LPS-induced production as well as NO, TNF-$\alpha$ and IL-6 secretion in a concentration-dependent manner. These results suggest that CMWE have potent inhibitory effects on the production of these inflammatory mediators.

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References

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