Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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The Clinical pilot study of Hwangryunhaedok-tang Pharmacopunctue therapy on Post-stroke depression

뇌졸중 후 우울증에 대한 황련해독탕 약침의 안전성 및 유효성 평가를 위한 임상 시험

  • Je, Jun-Tae (Department of Oriental Internal Medicine and Neuroscience, Oriental Medical School, Wonkwang University) ;
  • Lee, Sang-Kwan (Department of Oriental Internal Medicine and Neuroscience, Oriental Medical School, Wonkwang University)
  • 제준태 (원광대학교 한의과대학 심계내과학 교실) ;
  • 이상관 (원광대학교 한의과대학 심계내과학 교실)
  • Received : 2010.03.16
  • Accepted : 2010.05.27
  • Published : 2010.06.30
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Abstract

Objective : The purpose of this study is to determine the efficacy and safely of Hwangryunhaedok-tang Pharmacopuncture (HHT-PA) therapy on post-stroke depression (PSD) in stroke patients. Methods : Fifteen PSD patients has been recruited and evaluated with liver function test (LFT) and renal function lest (RFT) and depression scales, Beck Depress ion Inventory (BDI) and Hamilton Depression Rating Scale (HAM-D) before and after HHT-PA treatment. Results : HAM-D score significantly decreased after HHT-PA treatment regard less of improving of motor function. But BDI score did not decrease significantly. All results of LFT and RFT were in normal range before and after HHT-PA treatment Conclusion : These results showed that HHT-PA decrease PSD symptoms and has safety on stroke patients, although has no effect on improving of motor impairment.

Keywords

References

  1. 전국한의과대학심계내과학교실. 심계내과학. 서울: 군자출판사. 2006:265-393.
  2. 안용팔, 이숙자, 양승한, 배광웅. 뇌졸중 편마비 환자의 의식구조. J.of Korean acad.of Rehab.Med.. 1984;8(2):92-8.
  3. Demecour CL, Caplan D. The relationship of depression to symptomatology and lesion site in aphasic patients. Cortex. 1991;27:385-401. https://doi.org/10.1016/S0010-9452(13)80034-2
  4. Kauhanen ML, Korpelainen JT, Hitunen P. Aphasia, depression, and non-verbal cognitive impairment in ischaemic stroke. Cerebrovasc Dis. 2000;10:455-61. https://doi.org/10.1159/000016107
  5. Kim P, Warren S, Madill H. Quality of life of stroke survivors. Qual Life Res. 1999;8:293-301. https://doi.org/10.1023/A:1008927431300
  6. King RB. Quality of life after stroke. Stroke. 1996;28:1467-72.
  7. Schwartz JA, Speed NM, Brunberg JA. Depression in stroke rehabilitation. Biol Psychiatry. 1993;33:694-9. https://doi.org/10.1016/0006-3223(93)90118-W
  8. Herrmann N, Black SE, Lawrence J. The Sunnybrook Stroke Study: a prospective study of depressive symptoms and functional outcome. Stroke. 1998;29:618-24. https://doi.org/10.1161/01.STR.29.3.618
  9. Ramasubbu R, Robinson RG, Flint AJ. Functional impairment associated with acute poststroke depression: the Stroke Data Band Study. J Neuropsychiatry Clin Neurosci. 1998;10:26-33. https://doi.org/10.1176/jnp.10.1.26
  10. Kotila M, Numminen H, Waltimo O. Poststroke depression and functional recovery in a population-based stroke register. The Finnstroke study. Eur J Neruol. 1999;6:309-12. https://doi.org/10.1046/j.1468-1331.1999.630309.x
  11. Pohjasvaara T, Vataja R, Leppavuori A. Depression in an independent predictor of poor long-term functional outcome post-stroke. Eur J Neurol. 2001;8:315-9. https://doi.org/10.1046/j.1468-1331.2001.00182.x
  12. Kauhanen M, Korpelainen JT, Hiltunen P. Poststoke depression correlates with cognitive impairment and neurological deficits. Stroke. 1999;30:1875-80. https://doi.org/10.1161/01.STR.30.9.1875
  13. Sinyor D, Amato P, Kaloupek DG. Post-stroke depression:relationships to functional impairment, coping strategies, and rehabilitaion outcome. Stroke. 1986;17:1102-7. https://doi.org/10.1161/01.STR.17.6.1102
  14. Paolucci S, Antonucci G, Pratesi L. Poststroke depression and its role in rehabilitation of inpatients. Arch Phys Med Rehabil. 1999;80:985-90. https://doi.org/10.1016/S0003-9993(99)90048-5
  15. Pohjasvaara T, Vataja R, Leppavuori A. Depression in an independent predictor of poor long-term functional outcome post-stroke. Eur J Neurol. 2001;8:315-9. https://doi.org/10.1046/j.1468-1331.2001.00182.x
  16. Gillen R, Tennen H, Mckee TE. Depressive symptoms and history of depression predict rehabilitation effeciency in stroke patients. Arch Phys Med Rehabil. 2001;82:1645-9. https://doi.org/10.1053/apmr.2001.26249
  17. Neau JP, Ingrand P, Mouille-Brachet C. Functional recovery and social outcome after cerebral infarction in young adults. Cerebrosc Dis. 1998;8:296-302. https://doi.org/10.1159/000015869
  18. Chemerinski E, Robinson RG, Kosier JT. Improved recovery in activities of daily living associated with remission of poststroke depression. Stroke, 2001;32:113-7. https://doi.org/10.1161/01.STR.32.1.113
  19. Kondo Y, Kondo F, Asanuma M, Tanaka K, Ogawa N. Protective effect of oren-gedoku-to against induction of neuronal death by transient cerebral ischemia in the C57BL/6 mouse. Neurochem Res. 2000;25(2):205-9. https://doi.org/10.1023/A:1007515318434
  20. Kabuto H, Asanuma M, Nishibayashi S, Iida M, Ogawa N. Chronic administration of Orengendoku-to(TJ15) inhibitis ischemia-induced changes in brain indoleamine metabolism and muscarnic receptor binding in the Mongolian gerbil. Neurochem Res. 1997;22(1):33-6. https://doi.org/10.1023/A:1027369119224
  21. Kim YO, Leem K, Park J, Lee P, Ahn DK, Lee BC, Park HK, Suk K, Kim SY, Kim H. Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia. J. Ethnopharmacology. 2001;77(2-3):183-8. https://doi.org/10.1016/S0378-8741(01)00283-5
  22. 신길조, 조기호, 금영석, 배형섭, 이경섭. 황련해독탕의 약침제제의 안정성 및 효능에 관한 연구. 경희한의대논문집. 1994;17(1):85-115.
  23. 설현, 육태한. 견정혈 황련해독탕약침이 심박변이율(HRV)에 미치는 영향. 대한침구학회지. 2004;21(6):37-50.
  24. Cho GL, Kim JU, Lee YJ, Rhim EK, Shin SH, Kim DW, Hong SH, Joo JC. Two cases of Chest Heating Sensation treated by Hwangryunhaedok-tang Herbal-Acapuncture. 2003;6(2):127-135. https://doi.org/10.3831/KPI.2003.6.2.127
  25. Jang HH, Lee DY, Lee SH, Kang HW, Lyn YS, Clinical Studies on HWANGRYUNHAEDOKTANG Herbal Acapuncture Therapy on Headache. 2003;6(1):52-60. https://doi.org/10.3831/KPI.2003.6.1.052
  26. 王懷德. 太平聖惠方 1. 서울:한성사. 1980:3211-3.
  27. Han HM, Yum TH, Shin YW, Kim KH, Yoon DJ, Chung KJ. A standardization study of back depression inventory in Korea. Neuropsychiatry 1986;25:487-98.
  28. Hedlund JL, Viewig BW. The Hamilton rating scale for depression. Journal of Operational Psychiatry. 1979;10(2):149-165.
  29. 이중서, 배승오, 안용민, 박두병, 노경선, 신현균, 우행원, 이홍식, 한상익, 김용식. 한국판 Hamilton 우울증 평가 척도의 신뢰도, 타당도 연구. J.Korean Neuropsychiatr Assoc. 2005;44(4):456-65.
  30. Robinson RG. Poststroke Depression : Prevalence, Diagnosis, Treatment, and Disease Progression. Biol psychiatry 2003;54:376-87. https://doi.org/10.1016/S0006-3223(03)00423-2
  31. Huff W, Steckel R, Sistzer M. Poststroke depression : Risk factors and effects on the course of the stroke. Nervenarzt 2003;74:104-14. https://doi.org/10.1007/s00115-002-1417-x

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