Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
권호 표지

Enhancement of Anticancer Activities of Low Quality Ginseng by Phelinus linteus Fermentation

상황 균사체 배양에 의한 파삼의 항암 활성 증진

  • Ha, Ji-Hye (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Jeong, Myeong-Hoon (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Seo, Yong-Chang (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Choi, Woon-Yong (College of Bioscience and Biotechnology, Kangwon National University) ;
  • Jeong, Heon-Sang (College of Agriculture, Life & Enviroent Sience, Chungbuk National University) ;
  • Jung, Jae-Hyun (Department of Food and Biotechnology, Chungju National University) ;
  • Yu, Kwang-Wan (Department of Food and Biotechnology, Chungju National University) ;
  • Lee, Hyeon-Yong (College of Bioscience and Biotechnology, Kangwon National University)
  • 하지혜 (강원대학교 BT특성화학부대학) ;
  • 정명훈 (강원대학교 BT특성화학부대학) ;
  • 서용창 (강원대학교 BT특성화학부대학) ;
  • 최운용 (강원대학교 BT특성화학부대학) ;
  • 정헌상 (충북대학교 식품공학과) ;
  • 정재헌 (충주대학교 식품생명공학과) ;
  • 유광원 (충주대학교 식품생명공학과) ;
  • 이현용 (강원대학교 BT특성화학부대학)
  • Received : 2010.03.24
  • Accepted : 2010.05.11
  • Published : 2010.06.30
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Abstract

Low quality fresh ginseng was fermented by Pheliuus linteus mycelium at $22^{\circ}C$ for 30 days, then extracted by water solvent at $100^{\circ}C$ for 180 min. On human normal cell lines (HEK293), cytotoxicity was about 10% lower in adding extracts of the fermentation ginseng than that from low quality ginseng. The fermented extracts also inhibited the growth of several human cancer cells. Among them, respectively, digestive organs related cancer cells, such as human stomach adenocarcnioma and human epithelial adenocarcinoma were most effectively inhibited up to 85% and 90%, respectively. Then, selectivities were in the ranges of 3 to 5, compared to 2 to 3 from low quality fresh ginseng. Generally, fermented ginseng extract showed higher anticancer activities as well as higher DPPH radical sacavening activity, possibly due to high contents of total phenolic components as 6.96 mg/g. It was very interesting that the fermented ginseng contained very higher contents of ginsenoside-Rc+$Rb_2$, compared to others in low quality fresh ginseng because of partition digestion of mycelium growth. The results can tell that low quality fresh ginseng can be utilized by the fermentation with Pheliuus linteus mycelium.

Keywords

References

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