Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Sasa borealis leaves extract improves insulin resistance by modulating inflammatory cytokine secretion in high fat diet-induced obese C57/BL6J mice

  • Yang, Jung-Hwa (Department of Food and Nutrition, Chonnam National University) ;
  • Lim, Hyeon-Sook (Department of Food and Nutrition, Chonnam National University) ;
  • Heo, Young-Ran (Department of Food and Nutrition, Chonnam National University)
  • Received : 2010.02.11
  • Accepted : 2010.03.12
  • Published : 2010.04.28
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Abstract

Obesity is considered a mild inflammatory state, and the secretion of inflammation-related cytokines rises as adipose tissue expands. Inflammatory cytokines, including tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interlukin 6 (IL-6) and monocyte-chemoattractant protein 1 (MCP-1), are modulated by adipose tissue and known to play an important role in insulin resistance which is the common characteristics of obesity related disorders. In this study we analyzed the effects of Sasa borealis leaves extract on inflammatory cytokines and insulin resistance in diet induced obese C57/BL6J mice. The obese state was induced by a high fat diet for 20 weeks and then the mice were divided into two groups; obese control group (OBC, n = 7) and experimental group (OB-SBE, n = 7). The OBC group was fed a high fat diet and the OB-SBE group was fed a high fat diet containing 5% Sasa borealis leaves extract (SBE) for 12 weeks. We also used mice fed a standard diet as a normal control (NC, n = 7). The body weight and adipose tissue weight in the OB group were significantly higher than those in the NC group. The effects of the high fat diet were reduced by SBE treatments, and the body weight and adipose tissue deposition in the OB-SBE group were significantly decreased compared to the OBC group. The OBC group showed higher serum glucose and insulin levels which resulted in a significant increase of incremental area under the curve (IAUC) and HOMA-IR than the NC group. Also, serum leptin, TNF-${\alpha}$, and IL-6 levels were significantly higher in the OBC group than in the NC group. In contrast, the OB-SBE group showed a reversal in the metabolic defects, including a decrease in glucose, insulin, IAUC, HOMA-IR, TNF-${\alpha}$, IL-6 and leptin levels. These results suggest that BSE can suppress increased weight gain and/or fat deposition induced by a high fat diet and theses effects are accompanied by modulation of the inflammatory cytokines, TNF-${\alpha}$ and IL-6 secretion resulting in improved insulin resistance.

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References

  1. Laclaustra M, Corella D, Ordovas J. Metabolic syndrome pathophysiology: the role of adipose tissue. Nutr Metab Cardiovasc Dis 2007;17:125-39. https://doi.org/10.1016/j.numecd.2006.10.005
  2. Trayhurn P. Endocrine and signaling role of adipose tissue: new perspectives on fat. Acta Physiol Scand 2005;184:285-93. https://doi.org/10.1111/j.1365-201X.2005.01468.x
  3. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005;115:911-9. https://doi.org/10.1016/j.jaci.2005.02.023
  4. Wang CC, Galstone ML, Drazin B. Molecular mechanism of insulin resistance that impact cardiovascular biology. Diabetes 2004;53:2735-40. https://doi.org/10.2337/diabetes.53.11.2735
  5. Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest 2000;106:473-81. https://doi.org/10.1172/JCI10842
  6. Hae J. DongEuBoGam. Seoul: Namsangdang; 1990. p.140-2.
  7. Lu B, Wu X, Tie X, Zhang Y, Zhang Y. Toxicology and safty of anti-oxidant of bamboo leaves. Part 1: Acute and subchronic toxicity studies on anti-oxidant of bamboo leaves. Food Chem Toxicol 2005;43:783-92. https://doi.org/10.1016/j.fct.2005.01.019
  8. Lu B, Wu X, Shi J, Dong Y, Zhang Y. Toxicology and safty of anti-oxidant of bamboo leaves. Part 2: Developmental toxicity test in rat with antioxidant of bamboo leaves. Food Chem Toxicol 2006;44:1739-43. https://doi.org/10.1016/j.fct.2006.05.012
  9. Jung EY. Effect of the Sasa Borealis leaves extract on metabolic syndrome in C57/BL6j mice fed a high fat diet [master's thesis]. Gwanju: Chonnam National University; 2006.
  10. Kim EY, Jung EY, Lim HS, Heo YR. The effects of the Sasa Borealis leaves extract on plsma adiponectin, resistin, C-reactive protein and homocyteine levels in high fat diet-induced obese C57/BL6J mice. The Korean Journal of Nutrition 2007;40: 303-11.
  11. Ko BS, Jun DW, Jang JS, Kim JH, Park S. Effect of Sasa borealis and white lotus root and leaves on insulin action and secretion In Vitro. Korean Journal of Food Science and Technology 2006;38:114-20.
  12. Oh HK. Development of the hamburger patties containing Sasa Borealis bamboo leaves, Laminaria japonica or rice [doctor's thesis]. Gwangju: Chonnam National University; 2008.
  13. Park YO. Antioxidant activities of extracts of Sasa Borealis leaves [doctor's thesis]. Gwangju: Chonnam National University; 2008.
  14. Yun EK. Effects of Sasa Borealis leaves extract on glucose tolerance of major contributing foods to carbohydrate intake [master's thesis]. Gwanju: Chonnam National University; 2009.
  15. Choi YJ, Choi JS, Shin SY, Bae JY, Kang SW, Kang IJ, Kang YH. Blocked of chronic high glucose-induced endotherial apoptosis by Sasa borealis bamboo extract. Exp Biol Med 2008;233:580-91. https://doi.org/10.3181/0707-RM-205
  16. Hwang JY, Han JS. Inhibitory effects of Sasa borealis leaves extracts on carbohydrate digestive enzyme and postprandial hyperglycemia. Journal of the Korean Society of Food Science and Nutrition 2007;36:989-94. https://doi.org/10.3746/jkfn.2007.36.8.989
  17. Lee MJ, Park WH, Song YS, Lee YW, Song YO, Moon GS. Effect of bamboo culm extract on oxidative stress and genetic expression: Bamboo culm extract ameliorates cell adhesion molecule expression and NF$\kappa$B activity through the suppression of the oxidative stress. Clin Nutr 2008;27:755-63. https://doi.org/10.1016/j.clnu.2008.06.002
  18. Park EJ, Jhon DY. The antioxidant, angiotensin converting enzyme inhibition activity, and phenolic compounds of bamboo shoot extracts. LWT-Food Science and Technology 2010;43:655-9. https://doi.org/10.1016/j.lwt.2009.11.005
  19. Zang Y, Yao X, Bao B, Zhang Y. Anti-fatigue activity of a triterpenoid-rich extract from Chinese bamboo shavings (Caulis bamfusae in taeniam). Phytother Res 2006;20:872-8. https://doi.org/10.1002/ptr.1965
  20. Choi DB, Cho KA, Na MS, Choi HS, Kim YO, Lim DH, Cho SJ, Cho H. Effect of bamboo oil on antioxidative activity and nitrite scavenging activity. Journal of Industrial and Engineering Chemistry 2008;14:765-70. https://doi.org/10.1016/j.jiec.2008.06.005
  21. Cho H, Cho KA, Jia S, Cho SJ, Choi DB. Influence of bamboo oil supplementation on blood lipid concentration in serum. Journal of Industrial and Engineering Chemistry 2009;15:281-4. https://doi.org/10.1016/j.jiec.2008.12.002
  22. Pham B, Cranney A, Boers M, Verhoeven AC, Wells G, Tugwell P. Validity of area-under-the-curve analysis to summarize effect in rheumatoid arthritis clinical trials. J Rheumatol 1999;26:712-6.
  23. Hosker JP, Matthews DR, Rudenski AS, Burnett MA, Darling P, Bown EG, Turner RC. Continuous infusion of glucose with model assessment: measurement of insulin resistance and beta-cell function in men. Diabetologia 1985;28:401-11. https://doi.org/10.1007/BF00280882
  24. Kim S, Moustaid-Mossa N. Secretory, endocrine and autocrine/paracrine function of adipocyte. J Nutr 2000;130:3110S-3115S.
  25. Urs S, Heo YR, Kim S, Kim JH, Jones BH, Moustaid-Moussa N. Genomics, proteomics and nutrition: Applications to obesity research. Nutritional Sciences 2002;5:129-33.
  26. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112:1821-30. https://doi.org/10.1172/JCI19451
  27. Hotamisligil GS, Sharigill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993;259:87-91. https://doi.org/10.1126/science.7678183
  28. Moller DE. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab 2000;46:1526-31.
  29. Christiansen T, Richelsen B, Bruun JM. Monocyte chemoattractant protein-1 is produced in isolated adipocyte, associated with adiposity and reduced after weight loss in morbid obese subjects. Int J Obes (Lond) 2005;29:146-50. https://doi.org/10.1038/sj.ijo.0802839
  30. Sartipy P, Loskutoff DJ. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A 2003; 100:7265-70. https://doi.org/10.1073/pnas.1133870100
  31. Wang B, Jenkins JR, Trayhurn P. Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-$\alpha$. Am J Physiol Endocrinol Metab 2005;288:E731-40.
  32. German AJ, Hervera M, Hunter L, Holden SL, Morris PJ, Biourge V, Trayhurn. Improvement in insulin resistance and reduction in plsma inflammatory adipokines after weight loss in obese dogs. Domest Animal Endocrinol 2009;37:214-26. https://doi.org/10.1016/j.domaniend.2009.07.001
  33. Panee J. Bamboo extract in the prevention of diabetes and breast cancer. In: Watson RR, editors. Complementary and Alternative Therapies and the Aging Population: An Evidence-Based Approach. San Diego, ELSEVIER; 2008. p.159-77.
  34. Yoon KD, Kim CY, Huh H. The flavone glycosides of Sasa Borealis. Korean Journal of Pharmacognosy 2000;31:224-7.
  35. Mahato SB, Nandy AK, Roy G. Triterpenoids. Phytochemistry 1992;31:2199-249. https://doi.org/10.1016/0031-9422(92)83257-Y
  36. Jung HJ, Nam JH, Choi J, Lee KT, Park HJ. 19$\alpha$-hydroxyursane-type triterpenoids: antinociceptive anti-inflammatory principles of the roots of Rosa rugosa. Biol Pharm Bull 2005;28:101-4. https://doi.org/10.1248/bpb.28.101

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