YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antimicrobial Activity of Resveratrol Oligomers and Flavonoids from the Stems of Vitis coignetiae Pulliat and the Seeds of Perilla frutescens (L.) Britton

머루 줄기와 자소자로부터 분리한 Resveratrol 올리고머와 Flavonoid의 항균효과

  • Son, Rak-Ho (R&D Center, Jung San Bio Technology) ;
  • Chin, Hwi-Seung (R&D Center, Jung San Bio Technology) ;
  • Ham, Ah-Rom (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Mar, Woong-Chon (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Nam, Kung-Woo (R&D Center, Jung San Bio Technology)
  • 손락호 (정산생명공학연구소) ;
  • 진휘승 (정산생명공학연구소) ;
  • 함아름 (서울대학교천연물과학연구소) ;
  • 마응천 (서울대학교천연물과학연구소) ;
  • 남궁우 (정산생명공학연구소)
  • Received : 2009.09.09
  • Accepted : 2009.12.08
  • Published : 2010.02.28
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Abstract

We studied the antimicrobial activities of five compounds isolated from the stems of Vitis coignetiae Pulliat and the seeds of Perilla frutescens (L.) Britton. Based on spectroscopic evidence, compounds 1 to 5 were characterized as resveratrol, $\varepsilon$-viniferin, ampelopsin E, apigenin, and luteolin, respectively. The antimicrobial activities against Gram-positive (Staphylococcus aureus) and -negative (Pseudomonas aeruginosa) bacteria and a fungus (Candida albicans) were investigated using the disc diffusion and broth dilution methods. C. albicans was not inhibited by the five compounds. Compounds 2 and 5 had significant anti-microbial activity against S. aureus, and the 50% inhibitory concentration ($IC_{50}$) of compound 2 against S. aureus was 7.2 ${\mu}M$. Compounds 4 and 5 significantly inhibited P. aeruginosa and the minimum inhibitory concentration (MIC) of compounds 2 and 5 was 0.07 and 2.0 ${\mu}M$, respectively. Compounds 2, 4, and 5 had strong anti-microbial activity against S. aureus and P. aeruginosa.

Keywords

References

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