Annals of Rehabilitation Medicine

Korean Academy of Rehabilitation Medicine (대한재활의학회)
권호 표지

Effects of Continuous Repetitive Transcranial Magnetic Stimulation on Pain Response in Spinal Cord Injured Rat

척수손상 흰쥐의 통증에 대한 지속적인 반복 경두개 자기자극의 효과

  • Bae, Young-Kyung (Department of Pathology, College of Medicine, Yeungnam University) ;
  • Kim, Su-Jeong (Institute of Medical Science, Yeungnam University) ;
  • Seo, Jeong-Min (Department of Molecular Medicine, Kyungpook National University School of Medicine) ;
  • Cho, Yun-Woo (Department of Rehabilitation Medicine, College of Medicine, Yeungnam University) ;
  • Ahn, Sang-Ho (Department of Rehabilitation Medicine, College of Medicine, Yeungnam University) ;
  • Kang, In-Soon (Department of Rehabilitation Medicine, School of Medicine, Catholic University of Daegu) ;
  • Park, Hea-Woon (Department of Rehabilitation Medicine, School of Medicine, Catholic University of Daegu) ;
  • Hwang, Se-Jin (Department of Anatomy and Cell Biology, College of Medicine, Hanyang University)
  • 배영경 (영남대학교 의과대학 병리학교실) ;
  • 김수정 (영남대학교 의과학연구소) ;
  • 서정민 (경북대학교 의학전문대학원 분자의학교실) ;
  • 조윤우 (영남대학교 의과대학 재활의학교실) ;
  • 안상호 (영남대학교 의과대학 재활의학교실) ;
  • 강인순 (대구가톨릭대학교 의과대학 재활의학교실) ;
  • 박해운 (대구가톨릭대학교 의과대학 재활의학교실) ;
  • 황세진 (한양대학교 의과대학 해부세포생물학교실)
  • Received : 2009.11.17
  • Accepted : 2010.04.02
  • Published : 2010.06.30
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Abstract

Objective: To investigate the effects of continuous repetitive transcranial magnetic stimulation (rTMS) on pain response in spinal cord injured rat. Method: Forty Sprague-Dawley rats (200~250 grams, female) were used. Thoracic spinal cord (T9) was contused using New York University (NYU) spinal cord impactor. Ten gram weight rod was dropped from a height of 25 mm to produce spinal cord contusion model with moderate injury. The animals were randomly assigned to two groups: one exposed to real magnetic stimulation (real-rTMS group) and the other not exposed to magnetic stimulation (shamrTMS group). rTMS was applied for 8 weeks. To assess the effect of continuous rTMS on below-level pain responses after spinal cord injury (SCI), the hindpaw withdrawal response for thermal stimuli, cold stimuli and mechanical stimuli were compared between two groups. Results: Behavioral response for pain showed that hindpaw withdrawal response for cold stimuli was reduced significantly from 4 weeks after SCI in real-rTMS group compared with sham group (p<0.05). Conclusion: These results suggest that continuous rTMS may have beneficial effects on attenuation of cold allodynia after SCI, and it might be an additional non-invasive therapeutic method in patients with chronic neuropathic pain after SCI.

Keywords

Acknowledgement

Supported by : 한국학술진흥재단

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