The Korean Journal of Gastroenterology (대한소화기학회지)

The Korean Society of Gastroenterology (대한소화기학회)
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The Role of Epithelial-mesenchymal Transition in the Gastroenterology

소화기 영역에서 Epithelial-mesenchymal Transition의 역할

  • Kim, Sung-Moo (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Han, Joung-Ho (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Park, Seon-Mee (Department of Internal Medicine, Chungbuk National University College of Medicine)
  • 김성무 (충북대학교 의과대학 내과학교실) ;
  • 한정호 (충북대학교 의과대학 내과학교실) ;
  • 박선미 (충북대학교 의과대학 내과학교실)
  • Published : 2010.08.25
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Abstract

The epithelial-mesenchymal transition (EMT) plays physiologic roles in the embryogenesis, wound healing, and tissue regeneration. In terms of pathological direction, it causes organ fibrosis, cancer development, progression, metastasis, and chemoresistance. Recently, the underlying mechanism of EMT and many kinds of EMT regulators have been identified. Pharmaceutical treatment strategies which target EMT pathway could be applied for the prevention of tissue fibrosis and cancer progression. In the field of gastroenterology, profuse evidences have been collected about the critical roles of EMT in cancers of the gastrointestinal tract, liver, and pancreas and hepatic fibrosis. However, EMT varies widely among cancer types, and much remains to be identified about the main regulators of EMT in a specific disease. In this review, we present recent research results regarding the roles of EMT in cancers and organic fibrosis, especially in the area of gastroenterology.

Keywords

References

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