Infection and chemotherapy

The Korean Society of Infectious Diseases (대한감염학회)
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IgE-Mediated Hypersensitivity Reactions to Cephalosporins

IgE매개 세팔로스포린 과민반응

  • Kim, Baek-Nam (Department of Internal Medicine1, Inje University SanggyePaik Hospital, Inje Uni versity College of Medicine) ;
  • Cho, You-Sook (Division of Allergy and Clinical Immunology, Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 김백남 (인제대학교 의과대학 상계백병원 내과학교실) ;
  • 조유숙 (울산대학교 의과대학 서울아산병원 내과학교실)
  • Received : 2010.05.10
  • Published : 2010.06.30
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Abstract

Cephalosporins are commonly prescribed either orally or parenterally for the treatment of bacterial infections because of wide safety margin compared with penicillins. Skin testing with a parent cephalosporin antibiotic has routinely been performed in Korea in the fear of developing anaphylaxis after the administration of a cephalosporin although penicillins are antibiotics that most commonly induce severe or life-threatening IgE-mediated reactions (anaphylaxis). In this review, we will discuss IgE-mediated hypersensitivity reactions to cephalosporins. Immunopathogenesis of IgE-mediated hypersensitivity reaction to cephalosporins, limitations of skin testing with parent cephalosporin antibiotics, and prescription strategy of cephalosporins for patients with a history of cephalosporin or penicillin hypersensitivity was described.

Keywords

References

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