Journal of The Korean Ophthalmological Society (대한안과학회지)

The Korean Ophthalmological Society (대한안과학회)
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Use of Spectral-Domain Optical Coherence Tomography to Analyze Macular Thickness According to Refractive Error

스펙트럼 영역 빛간섭단층촬영기를 이용한 근시 정도에 따른 황반 구조의 정량적 분석

  • Kim, Seung-Hoon (Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine) ;
  • Park, Joo-Youn (Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine) ;
  • Park, Tae-Kwann (Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine) ;
  • Ohn, Young-Hoon (Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine)
  • 김승훈 (순천향대학교 의과대학 부천병원 안과학교실) ;
  • 박주연 (순천향대학교 의과대학 부천병원 안과학교실) ;
  • 박태관 (순천향대학교 의과대학 부천병원 안과학교실) ;
  • 온영훈 (순천향대학교 의과대학 부천병원 안과학교실)
  • Published : 2011.11.15
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Abstract

Purpose: To investigate the correlation of macular retinal thickness and refractive error using spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 120 eyes with no posterior abnormalities were enrolled in the present study. Subjects were divided into 3 groups based on their spherical equivalent. Visual acuity, refraction, slit lamp examination, tonometry and fundus examination were performed. Retinal thickness between the RPE and IS/OS junction was measured at the fovea, 1 mm (inner ring) and 2 mm (outer ring) superiorly, inferiorly, nasally and temporally using SD-OCT. Overall average thickness, average foveal thickness, and the inner and outer ring macular thickness were measured. Results: The average foveal thickness was significantly greater in the high myopic eyes than in the low to moderate myopic and emmetropic eyes (p = 0.001). However, the RPE-IS/OS junction thickness of the foveola and the outer macular thickness were significantly lower (p = 0.001, p = 0.002) in the high myopic eyes. There was a weak, but significant negative correlation between refractive error and average foveal thickness (r = -0.38, p = 0.001). A positive correlation was found between refractive error and the RPE-IS/OS junction thickness (r = 0.40, p = 0.001). Conclusions: Macular retinal thickness is related to refractive error in normal subjects. Effects of eyeball elongation are more apparent in high myopic eyes than in low to moderate myopic eyes. A significant decline in the RPE-IS/OS junction thickness suggests the photoreceptor outer segments in the foveola are damaged in high myopic eyes.

목적: 근시 정도에 따른 황반 두께를 스펙트럼 영역 빛간섭단층촬영기(SD-OCT)를 이용하여 분석하였다. 대상과 방법: 120명 120안을 구면렌즈대응치에 따라 세 군으로 나누고 SD-OCT로 망막색소상피층(RPE)과 광수용체층(photoreceptor layer)의 내분절과 외분절의 접합부(IS/OS junction) 사이의 두께를 중심오목과 주변부에서 측정하였다. 또한 평균황반두께, ETDRS subfield 9개 영역 황반 두께를 비교하였다. 결과: 고도 근시안에서 중심 원의 황반 두께는 정시안과 중등도 근시안보다 매우 두꺼웠으며(p=0.001), 중심오목의 RPE와 IS/OS junction 사이의 두께 및 바깥쪽 원의 황반두께는 유의하게 얇았다(p=0.001, p=0.002). 구면렌즈대응치와 중심원의 황반 두께는 음의 상관관계를 보였으며, 중심오목의 RPE-IS/OS junction 사이의 두께와는 양의 상관관계를 보였다(r=-0.38, p=0.001; r=0.40, p=0.001). 결론: 굴절 상태와 황반 두께는 유의한 연관성이 있다. 특히 고도 근시안에서 안구 신장에 따른 효과가 뚜렷하게 나타나며 중심오목에서 광수용체층 외분절의 두께 감소가 나타난다.

Keywords

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