Journal of Breast Cancer

Korean Breast Cancer Society (한국유방암학회)
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Risk Factors and Control Strategies for the Rapidly Rising Rate of Breast Cancer in Korea

  • Park, Sue-K. (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Kim, Yeon-Ju (Epidemiology Program, University of Hawaii Cancer Center) ;
  • Kang, Dae-Hee (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Jung, En-Joo (Department of Preventive Medicine, Seoul National University College of Medicine) ;
  • Yoo, Keun-Young (Department of Preventive Medicine, Seoul National University College of Medicine)
  • Published : 2011.06.30
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Abstract

Due to the aging population and tremendous changes in life style over the past decades, cancer has been the leading cause of death in Korea. The incidence rate of breast cancer is the second highest in Korea, and it has shown an annual increase of 6.8% for the past 6 years. The major risk factors of breast cancer in Korean women are as follows: Early menarche, late menopause, late full-term pregnancy (FTP), and low numbers of FTP. Height and body mass index increased the risk of breast cancer in postmenopausal women only. There are ethnic variations in breast cancer due to the differences in genetic susceptibility or exposure to etiologic agent. With the epidemiological evidences on the possibility of further increase of breast cancer in Korea, the Korean Government began implementing the National Cancer Screening Program against breast cancer in 2002. Five-year survival rates for female breast cancer have improved significantly from 78.0% in early 1993-1995 to 90.0% in 2004-2008. This data indicate that improvement of the survival rate may be partially due to the early diagnosis of breast cancer as well as the increased public awareness about the significance of early detection and organized cancer screening program. The current pri- mary prevention programs are geared towards strengthening national prevention campaigns. In accordance with the improvement in 5-year survival rate, the overall cancer mortality has started to decrease. However, breast cancer death rate and incidence rates are still increasing, which need further organized effort by the Korean Government.

Keywords

References

  1. Annual report of causes of death 2009. Statistics Korea. http://kostat.go.kr. Accessed Feb 11th, 2011.
  2. Jung KW, Park S, Kong HJ, Won YJ, Lee JY, Park EC, et al. Cancer statistics in Korea: incidence, mortality, survival, and prevalence in 2008. Cancer Res Treat 2011;43:1-11. https://doi.org/10.4143/crt.2011.43.1.1
  3. Bray F, McCarron P, Parkin DM. The changing global patterns of female breast cancer incidence and mortality. Breast Cancer Res 2004;6:229-39. https://doi.org/10.1186/bcr932
  4. Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D. GLOBOCAN 2008, Cancer Incidence and mortality worldwide: IARC CancerBase No. 10. International Agency for Research on Cancer. http://globocan.iarc.fr. Accessed Feb 16th, 2011.
  5. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917. https://doi.org/10.1002/ijc.25516
  6. Ministry of Health, Welfare & Family Affairs. Annual Report of Cancer Incidence (2007), Cancer Prevalence (2007) and Survival (1993-2007) in Korea. Seoul: Ministry of Health, Welfare & Family Affairs; 2009.
  7. Suh JS, Yoo KY, Kwon OJ, Yun IJ, Han SH, Noh DY, et al. Menstrual and reproductive factors related to the risk of breast cancer in Korea: ovarian hormone effect on breast cancer. J Korean Med Sci 1996;11:501-8.
  8. Yoo KY, Kang D, Park SK, Kim SU, Kim SU, Shin A, et al. Epidemiology of breast cancer in Korea: occurrence, high-risk groups, and prevention. J Korean Med Sci 2002;17:1-6.
  9. Kim Y, Choi JY, Lee KM, Park SK, Ahn SH, Noh DY, et al. Dose-dependent protective effect of breast-feeding against breast cancer among ever-lactated women in Korea. Eur J Cancer Prev 2007;16:124-9. https://doi.org/10.1097/01.cej.0000228400.07364.52
  10. Yoo KY, Tajima K, Miura S, Takeuchi T, Hirose K, Risch H, et al. Breast cancer risk factors according to combined estrogen and progesterone receptor status: a case-control analysis. Am J Epidemiol 1997;146:307-14. https://doi.org/10.1093/oxfordjournals.aje.a009271
  11. Yoo KY, Tajima K, Kuroishi T, Hirose K, Yoshida M, Miura S, et al. Independent protective effect of lactation against breast cancer: a case-control study in Japan. Am J Epidemiol 1992;135:726-33.
  12. Yoo KY, Bae JM, Park ES, Ha MN, Suh JS, No DY, et al. Obesity as a determinant of age at menarche and age at menopause in a cross-sectional survey in Yonchon County, Korea. Seoul J Med 1995;36:137-45.
  13. Joo JS, Yoo KY, Shin MH, Noh DY, Choi KJ. Overweight related to the risk of breast cancer by menopausal status in Korea. J Korean Surg Soc 1994;46:937-48.
  14. Yoo K, Tajima K, Park S, Kang D, Kim S, Hirose K, et al. Postmenopausal obesity as a breast cancer risk factor according to estrogen and progesterone receptor status (Japan). Cancer Lett 2001;167:57-63. https://doi.org/10.1016/S0304-3835(01)00463-3
  15. Pike MC, Spicer DV, Dahmoush L, Press MF. Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. Epidemiol Rev 1993;15:17-35.
  16. Yoo KY, Kim H, Shin HR, Kang D, Ha M, Park SK, et al. Female sex hormones and body mass in adolescent and postmenopausal Korean women. J Korean Med Sci 1998;13:241-6.
  17. Shimizu H, Ross RK, Bernstein L, Yatani R, Henderson BE, Mack TM. Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. Br J Cancer 1991;63:963-6. https://doi.org/10.1038/bjc.1991.210
  18. Anderson WF, Chu KC, Chang S. Inflammatory breast carcinoma and noninflammatory locally advanced breast carcinoma: distinct clinicopathologic entities? J Clin Oncol 2003;21:2254-9. https://doi.org/10.1200/JCO.2003.07.082
  19. Lee JH, Yim SH, Won YJ, Jung KW, Son BH, Lee HD, et al. Population-based breast cancer statistics in Korea during 1993-2002: incidence, mortality, and survival. J Korean Med Sci 2007;22(Suppl):S11-6. https://doi.org/10.3346/jkms.2007.22.S.S11
  20. Choi Y, Kim YJ, Shin HR, Noh DY, Yoo KY. Long-term prediction of female breast cancer mortality in Korea. Asian Pac J Cancer Prev 2005;6:16-21.
  21. Park SK, Yoo KY, Lee SJ, Kim SU, Ahn SH, Noh DY, et al. Alcohol consumption, glutathione S-transferase M1 and T1 genetic polymorphisms and breast cancer risk. Pharmacogenetics 2000;10:301-9. https://doi.org/10.1097/00008571-200006000-00004
  22. Kim SU, Lee KM, Park SK, Yoo KY, Noh DY, Choe KJ, et al. Genetic polymorphism of glutathione S-transferase P1 and breast cancer risk. J Biochem Mol Biol 2004;37:582-5. https://doi.org/10.5483/BMBRep.2004.37.5.582
  23. Lee KM, Park SK, Kim SU, Doll MA, Yoo KY, Ahn SH, et al. N-acetyltransferase (NAT1, NAT2) and glutathione S-transferase (GSTM1, GSTT1) polymorphisms in breast cancer. Cancer Lett 2003;196:179-86. https://doi.org/10.1016/S0304-3835(03)00311-2
  24. Kim SU, Park SK, Yoo KY, Yoon KS, Choi JY, Seo JS, et al. XRCC1 genetic polymorphism and breast cancer risk. Pharmacogenetics 2002;12:335-8. https://doi.org/10.1097/00008571-200206000-00010
  25. Shin A, Kang D, Nishio H, Lee MJ, Park SK, Kim SU, et al. Estrogen receptor alpha gene polymorphisms and breast cancer risk. Breast Cancer Res Treat 2003;80:127-31. https://doi.org/10.1023/A:1024439202528
  26. Yim DS, Parkb SK, Yoo KY, Yoon KS, Chung HH, Kang HL, et al. Relationship between the Val158Met polymorphism of catechol O-methyl transferase and breast cancer. Pharmacogenetics 2001;11:279-86. https://doi.org/10.1097/00008571-200106000-00001
  27. Park SK, Yim DS, Yoon KS, Choi IM, Choi JY, Yoo KY, et al. Combined effect of GSTM1, GSTT1, and COMT genotypes in individual breast cancer risk. Breast Cancer Res Treat 2004;88:55-62. https://doi.org/10.1007/s10549-004-0745-x
  28. Shin A, Kang D, Choi JY, Lee KM, Park SK, Noh DY, et al. Cytochrome P450 1A1 (CYP1A1) polymorphisms and breast cancer risk in Korean women. Exp Mol Med 2007;39:361-6. https://doi.org/10.1038/emm.2007.40
  29. Shin MH, Lee KM, Yang JH, Nam SJ, Kim JW, Yoo KY, et al. Genetic polymorphism of CYP17 and breast cancer risk in Korean women. Exp Mol Med 2005;37:11-7. https://doi.org/10.1038/emm.2005.2
  30. Choi JY, Lee KM, Park SK, Noh DY, Ahn SH, Chung HW, et al. Genetic polymorphisms of SULT1A1 and SULT1E1 and the risk and survival of breast cancer. Cancer Epidemiol Biomarkers Prev 2005;14:1090-5. https://doi.org/10.1158/1055-9965.EPI-04-0688
  31. Lee KM, Choi JY, Park SK, Chung HW, Ahn B, Yoo KY, et al. Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk. Cancer Epidemiol Biomarkers Prev 2005;14:821-5. https://doi.org/10.1158/1055-9965.EPI-04-0330
  32. Lee SA, Lee KM, Park WY, Kim B, Nam J, Yoo KY, et al. Obesity and genetic polymorphism of ERCC2 and ERCC4 as modifiers of risk of breast cancer. Exp Mol Med 2005;37:86-90. https://doi.org/10.1038/emm.2005.12
  33. Lee SA, Lee KM, Park SK, Choi JY, Kim B, Nam J, et al. Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies. Breast Cancer Res Treat 2007;103:71-6. https://doi.org/10.1007/s10549-006-9348-z
  34. Choi JY, Hamajima N, Tajima K, Yoo KY, Yoon KS, Park SK, et al. hOGG1 Ser326Cys polymorphism and breast cancer risk among Asian women. Breast Cancer Res Treat 2003;79:59-62. https://doi.org/10.1023/A:1023305826726
  35. Jeon S, Choi JY, Lee KM, Park SK, Yoo KY, Noh DY, et al. Combined genetic effect of CDK7 and ESR1 polymorphisms on breast cancer. Breast Cancer Res Treat 2010;121:737-42. https://doi.org/10.1007/s10549-009-0640-6
  36. Lee KM, Park SK, Hamajima N, Tajima K, Choi JY, Noh DY, et al. Genetic polymorphisms of interleukin-1 beta (IL-1B) and IL-1 receptor antagonist (IL-1RN) and breast cancer risk in Korean women. Breast Cancer Res Treat 2006;96:197-202. https://doi.org/10.1007/s10549-005-9079-6
  37. Lee KM, Park SK, Hamajima N, Tajima K, Yoo KY, Shin A, et al. Genetic polymorphisms of TGF-beta1 & TNF-beta and breast cancer risk. Breast Cancer Res Treat 2005;90:149-55. https://doi.org/10.1007/s10549-004-3859-2
  38. Han S, Lee KM, Choi JY, Park SK, Lee JY, Lee JE, et al. CASP8 polymorphisms, estrogen and progesterone receptor status, and breast cancer risk. Breast Cancer Res Treat 2008;110:387-93. https://doi.org/10.1007/s10549-007-9730-5
  39. Lee JY, Choi JY, Lee KM, Park SK, Han SH, Noh DY, et al. Rare variant of hypoxia-inducible factor-1alpha (HIF-1A) and breast cancer risk in Korean women. Clin Chim Acta 2008;389:167-70. https://doi.org/10.1016/j.cca.2007.12.005
  40. Lee JY, Park AK, Lee KM, Park SK, Han S, Han W, et al. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. Carcinogenesis 2009;30:1528-31. https://doi.org/10.1093/carcin/bgp084
  41. Choi JY, Abel J, Neuhaus T, Ko Y, Harth V, Hamajima N, et al. Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development. Pharmacogenetics 2003;13:67-72. https://doi.org/10.1097/00008571-200302000-00002
  42. Park SK, Kang D, Noh DY, Lee KM, Kim SU, Choi JY, et al. Reproductive factors, glutathione S-transferase M1 and T1 genetic polymorphism and breast cancer risk. Breast Cancer Res Treat 2003;78:89-96. https://doi.org/10.1023/A:1022113713226
  43. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 2007;447:1087-93. https://doi.org/10.1038/nature05887
  44. Korea Centers for Disease Control & Prevention. Korea Health Statistics 2009: Korea National Health and Nutrition Examination Survey (KNHANESIV-3). Seoul: Korea Centers for Disease Control & Prevention; 2010.
  45. Shin HR, Joubert C, Boniol M, Hery C, Ahn SH, Won YJ, et al. Recent trends and patterns in breast cancer incidence among Eastern and Southeastern Asian women. Cancer Causes Control 2010;21:1777-85. https://doi.org/10.1007/s10552-010-9604-8
  46. Kim Y, Jun JK, Choi KS, Lee HY, Park EC. Overview of the national cancer screening programme and the cancer screening status in Korea. Asian Pac J Cancer Prev 2011;12:725-30.
  47. Kwon S. Thirty years of national health insurance in South Korea: lessons for achieving universal health care coverage. Health Policy Plan 2009;24:63-71.
  48. National Health Insurance Corporation. National Health Screening Statistical Yearbook 2009. Seoul: National Health Insurance Corporation; 2010.
  49. National Cancer Center Korea. Cancer Facts & Figures. Goyang: National Cancer Center Korea; 2011.
  50. Lim SM, Lee HY, Choi KS, Jun JK, Park EC, Kim Y, et al. Trends of mammography use in a national breast cancer screening program, 2004-2008. Cancer Res Treat 2010;42:199-202. https://doi.org/10.4143/crt.2010.42.4.199
  51. Oh DK, Shim JI, Han M, Kim Y, Lee HY, Jun JK, et al. Breast cancer screening in Korean women: report of the national cancer screening program in 2008. J Breast Cancer 2010;13:299-304. https://doi.org/10.4048/jbc.2010.13.3.299
  52. Yoo KY. Cancer prevention in the Asia Pacific region. Asian Pac J Cancer Prev 2010;11:839-44.

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