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A Case of Coinfection with Pandemic (H1N1) 2009 Influenza and Scrub Typhus with Abnormal Liver Function Test

간기능 검사 이상이 동반된 대유행 인플루엔자(H1N1 2009)와 쯔쯔가무시병 동시감염 1예

  • Ahn, Yong-Chel (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Hwang, Jenie Yoon-Oo (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Yu-Seok (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Joo-Hui (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Cho, Oh-Hyun (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lim, Chae-Man (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Woo, Jun-Hee (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine)
  • 안용철 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 황윤우 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 김유석 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 김주희 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 조오현 (울산대학교 의과대학 서울아산병원 감염내과학교실) ;
  • 임채만 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 우준희 (울산대학교 의과대학 서울아산병원 감염내과학교실)
  • Received : 2010.10.07
  • Accepted : 2010.10.18
  • Published : 2011.03.30

Abstract

The pandemic (H1N1) 2009 influenza outbreak coincided with the typical Scrub typhus season, which can lead to diagnostic difficulties due to their similar and non-specific symptoms. Here we describe a case of laboratory confirmed co-infection of Pandemic (H1N1) 2009 influenza and Scrub typhus and discuss the difficulties in distinguishing the two illnesses clinically.

Keywords

References

  1. Centers for Disease Control and Prevention (CDC). Swine influenza A (H1N1) infection in two children--Southern California, March-April 2009. MMWR Morb Mortal Wkly Rep 2009;58:400-2.
  2. Kim WJ. Epidemiology, clinical manifestations, and management of pandemic novel Influenza A (H1N1). Korean J Med 2009;77:157-64.
  3. Seong SY, Choi MS, Kim IS. Orientia tsutsugamushi infection: overview and immune responses. Microbes Infect 2001;3:11-21. https://doi.org/10.1016/S1286-4579(00)01352-6
  4. Kim DM. Clinical features and diagnosis of scrub typhus. Infect Chemother 2009;41:315-22. https://doi.org/10.3947/ic.2009.41.6.315
  5. Suttinont C, Losuwanaluk K, Niwatayakul K, Hoontrakul S, Intaranongpai W, Silpasakorn S, et al. Causes of acute, undifferentiated, febrile illness in rural Thailand: results of a prospective observational study. Ann Trop Med Parasitol 2006;100:363-70. https://doi.org/10.1179/136485906X112158
  6. Senanayake SN. Swine flu update: bringing home the bacon. Med J Aust 2009;191:138-40.
  7. Na S, Kim MN, Kim WY, Kim W, Hong SB, Lim CM, et al. Prevalence and clinical features of pneumonia in patients with laboratory-confirmed pandemic influenza A H1N1 2009 infection in South Korea. Scand J Infect Dis 2011;43:19-26. https://doi.org/10.3109/00365548.2010.524656
  8. Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza, Bautista E, Chotpitayasunondh T, Gao Z, Harper SA, Shaw M, et al. Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med 2010;362:1708-19. https://doi.org/10.1056/NEJMra1000449
  9. Mueller MR, Smith PJ, Baumbach JP, Palumbo JP, Meek JI, Gershman K, et al. Influenza testing and antiviral prescribing practices among emergency department clinicians in 9 states during the 2006 to 2007 influenza season. Ann Emerg Med 2010;55:32-9. https://doi.org/10.1016/j.annemergmed.2009.09.019
  10. Chang WH. Current status of tsutsugamushi disease in Korea. J Korean Med Sci 1995;10:227-38.
  11. Park JI, Han SH, Cho SC, Jo YH, Hong SM, Lee HH, et al. Outbreak of hepatitis by Orientia tsutsugamushi in the early years of the new millenium. Korean J Hepatol 2003;9:198-204.
  12. Polakos NK, Cornejo JC, Murray DA, Wright KO, Treanor JJ, Crispe IN, et al. Kupffer cell-dependent hepatitis occurs during influenza infection. Am J Pathol 2006;168:1169-78. https://doi.org/10.2353/ajpath.2006.050875
  13. Daude M, Mansuy JM, Guitard J, Basse G, Esposito L, Izopet J, et al. Influenza A (H1N1) virus-induced hepatocellular injury in a kidney transplant patient. Transpl Infect Dis 2011;13:70-2. https://doi.org/10.1111/j.1399-3062.2010.00551.x
  14. Tullu MS. Oseltamivir. J Postgrad Med 2009;55:225-30. https://doi.org/10.4103/0022-3859.57411
  15. Park KH, Lee SO, Choi SH, Kim MN, Lee JH, Yi H, et al. Successful salvage therapy with inhaled zanamivir in a patient with peramivir-resistant pandemic influenza A (H1N1) 2009 virus. Scand J Infect Dis 2011;43:151-5. https://doi.org/10.3109/00365548.2010.515608

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  1. 가을철 유행하는 급성열성질환의 혼합감염 양상 vol.12, pp.12, 2011, https://doi.org/10.5392/jkca.2012.12.12.304
  2. Coinfection of H1N1 Influenza and Scrub Typhus-A Review vol.113, pp.7, 2011, https://doi.org/10.1093/qjmed/hcaa021