Ocean and Polar Research

Korea Institute of Ocean Science & Technology (한국해양과학기술원)
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Peroxynitrite-scavenging Activity of the Halophyte Limonium tetragonum

염생식물 갯질경이의 Peroxynitrite 소거 활성

  • Lee, Jung-Im (Division of Marine Environment & Bioscience, College of Ocean Science and Techology Korea Maritime University) ;
  • Kong, Chang-Suk (Department of Food and Nutrition, College of Medical and Life Sciences Silla University) ;
  • Jung, Myoung-Eun (Division of Marine Environment & Bioscience, College of Ocean Science and Techology Korea Maritime University) ;
  • Hong, Joo-Wan (Division of Marine Environment & Bioscience, College of Ocean Science and Techology Korea Maritime University) ;
  • Noh, Il (Division of Marine Environment & Bioscience, College of Ocean Science and Techology Korea Maritime University) ;
  • Seo, Young-Wan (Division of Marine Environment & Bioscience, College of Ocean Science and Techology Korea Maritime University)
  • 이정임 (한국해양대학교 해양과학기술대학 해양환경.생명과학부) ;
  • 공창숙 (신라대학교 의생명과학대학 식품영양학과) ;
  • 정명은 (한국해양대학교 해양과학기술대학 해양환경.생명과학부) ;
  • 홍주완 (한국해양대학교 해양과학기술대학 해양환경.생명과학부) ;
  • 노일 (한국해양대학교 해양과학기술대학 해양환경.생명과학부) ;
  • 서영완 (한국해양대학교 해양과학기술대학 해양환경.생명과학부)
  • Received : 2011.05.15
  • Accepted : 2011.05.30
  • Published : 2011.06.30
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Abstract

Crude extracts of Limonium tetragonum and their solvent-partitioned fractions were evaluated for their potential to scavenge authentic $ONOO^-$, and $ONOO^-$ derived from 3-morpholinosydnonimine (SIN-1). Four flavonol glycosides (1-4) were isolated by activity-guided separation. Their chemical structures were elucidated by extensive 2 D NMR experiments and by comparison with published spectral data. These compounds were also estimated for their peroxynitrite scavenging effects. The scavenging ratios of compounds 1-4 on authentic $ONOO^-$ were 56, 37, 56, and 54%, respectively, at a concentration of 1 ${\mu}M$. On the other hand, the inbihition ratios of compounds 1-4 against $ONOO^-$ generation from SIN-1 were 59, 39, 44, and 54% at the same concentration, respectively.

Keywords

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