Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Constituents of Flowers of Carthamus tinctorius L. and Their Antioxidant Activity

홍화의 성분 분리 및 항산화 활성

  • Choi, Hyun-Gyu (College of Pharmacy, Yeungnam University) ;
  • Jiang, Yan-Fu (College of Pharmacy, Yeungnam University) ;
  • Park, Sung-Hee (Department of Health & Medical Administration, Gyeongnam Provincial Geochangcollege) ;
  • Son, Ae-Ryang (Department of Beauty Design, Gyeongnam Provincial Geochangcollege) ;
  • Na, Min-Kyun (College of Pharmacy, Yeungnam University) ;
  • Lee, Seung-Ho (College of Pharmacy, Yeungnam University)
  • 최현규 (영남대학교 약학대학) ;
  • 강연복 (영남대학교 약학대학) ;
  • 박성희 (경남도립거창대학 보건의료행정과) ;
  • 손애량 (경남도립거창대학 뷰티디자인과) ;
  • 나민균 (영남대학교 약학대학) ;
  • 이승호 (영남대학교 약학대학)
  • Received : 2011.05.19
  • Accepted : 2011.05.26
  • Published : 2011.06.30
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Abstract

As part of our ongoing study focused on the discovery of antioxidants from natural products by measuring the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity, methanol extract of flowers of Carthamus tinctorius L. was found to show potent antioxidant activity. Activity-guided fractionation of the methanol extract lead to the isolation of twenty compounds including two flavonol glycosides, quercertin-3-O-${\beta}$-D-glucopyranoside (12) and kaempferol-3-O-${\alpha}$-L-rhamnopyranosyl-${\beta}$-D-glucopyranoside (18), two flavanone glycosides, (2S)-4',5,6,7-tetrahydroxyflavanone 6-O-${\beta}$-D-glucopyranoside (15) and (2R)-5,7,8',4-tetrahydroxyflavanone 8-O-${\beta}$-D-glucopyranoside (16), and two acetylenic glycosides, 8Z-decaene-4,6-diyne-1-O-${\beta}$-D-glucopyranoside (13) and 4,6-decadiyne-1-O-${\beta}$-D-glucopyranoside (14). Their chemical structures were identified by using spectroscopic analysis. Among them, compounds 12-18 were tested in DPPH assay. Compounds 13-16 were first reported to their antioxidant activity. Quercertin-3-O-${\beta}$-D-glucopyranoside (12) showed the most potent inhibitory effect on DPPH with $IC_{50}$ value of 56.7 ${\mu}M$.

Keywords

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