Acknowledgement
Supported by : Ministry of Health & Welfare
References
- Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066-71 https://doi.org/10.1056/NEJM199704103361506
- Blasius AL, Beutler B. Intracellular toll-like receptors. Immunity 2010;32:305-15 https://doi.org/10.1016/j.immuni.2010.03.012
- Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide- induced signal transduction. J Biol Chem 1999;274:10689-92 https://doi.org/10.1074/jbc.274.16.10689
- Czeh M, Gressens P, Kaindl AM. The yin and yang of microglia. Dev Neurosci 2011;33:199-209 https://doi.org/10.1159/000328989
- Egawa K, Sharma PM, Nakashima N, Huang Y, Huver E, Boss GR, Olefsky JM. Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance. J Biol Chem 1999;274:14306-14 https://doi.org/10.1074/jbc.274.20.14306
- Giri S, Rattan R, Singh AK, Singh I. The 15-deoxy-delta12, 14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma. J Immunol 2004;173:5196-208 https://doi.org/10.4049/jimmunol.173.8.5196
- Graeber MB, Streit WJ. Microglia: biology and pathology. Acta Neuropathol 2010;119:89-105 https://doi.org/10.1007/s00401-009-0622-0
- Hanke ML, Kielian T. Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin Sci (Lond) 2011;121:367-87 https://doi.org/10.1042/CS20110164
- Jeong HK, Jou I, Joe EH. Systemic LPS administration induces brain inflammation but not dopaminergic neuronal death in the substantia nigra. Exp Mol Med 2010;42:823-32 https://doi.org/10.3858/emm.2010.42.12.085
- Jing H, Zhou X, Dong X, Cao J, Zhu H, Lou J, Hu Y, He Q, Yang B. Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells. Cancer Lett 2010;294:167-77 https://doi.org/10.1016/j.canlet.2010.01.035
- Lawlor MA, Alessi DR. PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J Cell Sci 2001;114:2903-10
- Lee JY, Jhun BS, Oh YT, Lee JH, Choe W, Baik HH, Ha J, Yoon KS, Kim SS, Kang I. Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells. Neurosci Lett 2006;396:1-6 https://doi.org/10.1016/j.neulet.2005.11.004
- Li X, Tupper JC, Bannerman DD, Winn RK, Rhodes CJ, Harlan JM. Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells. Infect Immun 2003;71:4414-20 https://doi.org/10.1128/IAI.71.8.4414-4420.2003
- Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, Baldwin AS Jr, Mayo MW. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol 2000;20:1626-38 https://doi.org/10.1128/MCB.20.5.1626-1638.2000
- Madrid LV, Mayo MW, Reuther JY, Baldwin AS Jr. Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 2001;276:18934-40 https://doi.org/10.1074/jbc.M101103200
- Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-7 https://doi.org/10.1038/41131
- Nam KN, Son MS, Park JH, Lee EH. Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: neuroprotective implications. Neuropharmacology 2008;55:819-25 https://doi.org/10.1016/j.neuropharm.2008.06.065
- Nimmo AJ, Vink R. Recent patents in CNS drug discovery: the management of inflammation in the central nervous system. Recent Pat CNS Drug Discov 2009;4:86-95 https://doi.org/10.2174/157488909788452997
- O'Neill LA, Bowie AG. The family of five: TIR-domaincontaining adaptors in Toll-like receptor signalling. Nat Rev Immunol 2007;7:353-64 https://doi.org/10.1038/nri2079
- Orlikova B, Tasdemir D, Golais F, Dicato M, Diederich M. Dietary chalcones with chemopreventive and chemotherapeutic potential. Genes Nutr 2011;6:125-47 https://doi.org/10.1007/s12263-011-0210-5
- Ospelt C, Gay S. TLRs and chronic inflammation. Int J Biochem Cell Biol 2010;42:495-505 https://doi.org/10.1016/j.biocel.2009.10.010
- Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999;401:82-5 https://doi.org/10.1038/43466
- Park HY, Han MH, Park C, Jin CY, Kim GY, Choi IW, Kim ND, Nam TJ, Kwon TK, Choi YH. Anti-inflammatory effects of fucoidan through inhibition of NF-kappaB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells. Food Chem Toxicol 2011;49:1745-52 https://doi.org/10.1016/j.fct.2011.04.020
- Pietta PG. Flavonoids as antioxidants. J Nat Prod 2000;63: 1035-42 https://doi.org/10.1021/np9904509
- Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA 1998;95:588-93 https://doi.org/10.1073/pnas.95.2.588
- Saijo K, Glass CK. Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 2011;11:775-87 https://doi.org/10.1038/nri3086
- Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictormTOR complex. Science 2005;307:1098-101 https://doi.org/10.1126/science.1106148
- Shin SY, Hyun J, Lim Y, Lee YH. 3'-Chloro-5, 7-dimethoxyisoflavone inhibits TNFalpha-induced CXCL10 gene transcription by suppressing the NF-kappaB pathway in HCT116 human colon cancer cells. Int Immunopharmacol 2011a;11:2104-11 https://doi.org/10.1016/j.intimp.2011.09.003
- Shin SY, Woo Y, Hyun J, Yong Y, Koh D, Lee YH, Lim Y. Relationship between the structures of flavonoids and their NF-kappaB-dependent transcriptional activities. Bioorg Med Chem Lett 2011b;21:6036-41 https://doi.org/10.1016/j.bmcl.2011.08.077
- Sizemore N, Leung S, Stark GR. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol Cell Biol 1999;19:4798-805
- Wallace AC, Laskowski RA, Thornton JM. LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. Protein Eng 1995;8:127-34 https://doi.org/10.1093/protein/8.2.127
- Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990;249:1431-3 https://doi.org/10.1126/science.1698311
- Yadav VR, Prasad S, Sung B, Aggarwal BB. The role of chalcones in suppression of NF-kappaB-mediated inflammation and cancer. Int Immunopharmacol 2011;11:295-309 https://doi.org/10.1016/j.intimp.2010.12.006
- Yao LH, Jiang YM, Shi J, Tomas-Barberan FA, Datta N, Singanusong R, Chen SS. Flavonoids in food and their health benefits. Plant Foods Hum Nutr 2004;59:113-22 https://doi.org/10.1007/s11130-004-0049-7
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