The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Effects of Banhahubak-tang Extract on Psychological Stress

반하후박탕(半夏厚朴湯) 추출물이 생쥐에 유발된 심리적 스트레스에 미치는 영향

  • Lim, Se-Hyun (Department of Nursing, School of Public Health, Far East University) ;
  • Jeong, Hyun-Yun (College of Korean Medicine, Dong-Eui University) ;
  • Won, Ho-Young (Won Korean Medical Clinic) ;
  • Kim, Hyung-Woo (School of Korean Medicine, Pusan National University) ;
  • Choi, Chang-Won (Department of Korean Medicine, Dongshin University) ;
  • Jeong, Hyang-Sook (Department of Health and Welfare for the Elderly, Graduate School of Daegu Haany University) ;
  • Kim, Young-Gyun (College of Korean Medicine, Dong-Eui University) ;
  • Cho, Su-In (School of Korean Medicine, Pusan National University)
  • Received : 2012.06.10
  • Accepted : 2012.06.26
  • Published : 2012.07.30
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Abstract

Objective : Banhahubak-tang is indicated for globus hystericus, marked by a subjective sensation as if something stuffed in the throat, chest distress, cough or vomiting, greasy whitish, taut and smooth pulse. In this study, the effects of Banhahubak-Tang extract (BHTe) were tested for anti-stress action. Methods : BHTe was extracted by pure water using electronic extractor and then fed to ICR male mice ($20{\pm}2g$) orally with the dose of 100mg/kg/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days. Results : BHTe administered group showed a tendency of decreasing of serum corticosterone secretion when compared with control group, and BHTe administration also significantly up-regulated noradrenaline secretions in the dorsal cortex of brain. Lipid peroxidation of the brain tissues of mice were tested by measuring malondialdehyde, but BHTe showed no significant change. The elevated plus-maze test was designed to detect the effect of anxiolytic drugs, and BHTe administered group showed a significant increase of latency time. Conclusions : These results suggest that BHTe can effectively rid the psychological stress and it's related diseases.

Keywords

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