Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Characterization and Transdermal Delivery of Ethosomes Loaded with Eucommia ulmoides Extract

두충 추출물을 담지한 에토좀의 특성 및 경피 전달

  • Gu, Hyun A (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Kim, Hae Soo (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Kim, Moon Jin (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Yu, Eun Ryeong (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Joe, Gijung (Somang Cosmetics Co., Ltd.) ;
  • Jang, Jindong (Somang Cosmetics Co., Ltd.) ;
  • Kim, Bohyeon (Somang Cosmetics Co., Ltd.) ;
  • Park, Soo Nam (Department of Fine Chemistry, Nanobiocosmetic Laboratory and Cosmetic R&D Center, Seoul National University of Science and Technology)
  • 구현아 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실, 화장품종합기술연구소) ;
  • 김해수 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실, 화장품종합기술연구소) ;
  • 김문진 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실, 화장품종합기술연구소) ;
  • 유은령 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실, 화장품종합기술연구소) ;
  • 조기정 (소망화장품(주)) ;
  • 장진동 (소망화장품(주)) ;
  • 김보현 (소망화장품(주)) ;
  • 박수남 (서울과학기술대학교 정밀화학과 나노바이오화장품연구실, 화장품종합기술연구소)
  • Received : 2013.08.07
  • Accepted : 2013.09.10
  • Published : 2013.12.10
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Abstract

In this study, ethosomes loaded with Eucommia ulmoides extracts that have anti-inflammatory and anti-aging activities on the skin were prepared as cosmetic materials. The particle size, physical property, and entrapment efficiency of ethosomes to identify their stabilities during 4 weeks were measured. Ethosomes containing 0.01~0.05% E. ulmoides extracts did not show either precipitation or separation. The mean particle size of these ethosomes was 136.4 nm, and monodisperse. The particle size of ethosome containing 0.05% E. ulmoides extracts was 151.15 nm and the entrapment efficiency was 81.79%. Therefore, in vitro skin permeation experiment was performed with ethosome containing 0.05% E. ulmoides extracts that showed the high loading efficiency and stability during 4 weeks. The order of skin permeation of E. ulmoides extracts was ethosome (77.16%) > liposome (62.80%) > ethanolic solutoin (41.59%). These results suggest that ethosomes containing 0.05% E. ulmoides extracts are effective for the skin permeation and may be used as a cosmetic formulation containing plant extracts.

본 연구에서는 화장품 소재로서 항염, 항노화 효능이 있는 두충 추출물을 담지한 에토좀을 제조하였고, 이들 에토좀이 안정한지를 확인하기 위하여 4주 동안 입자크기, 물리적 특성 및 포집효율을 측정하였다. 0.01~0.05% 두충 추출물을 담지한 에토좀은 4주 동안 침전이나 분리 현상이 나타나지 않았다. 이들 에토좀의 평균 입자 크기는 134.6 nm였고, 단분산 형태를 나타내었다. 0.05% 두충 추출물을 함유한 에토좀의 입자 크기는 151.15 nm였으며, 포집 효율은 81.79%로 에토좀 중 가장 큰 포집효율을 나타내었다. 0.05% 두충 추출물을 담지한 에토좀을 이용하여 피부 투과 실험을 수행하였다. 두충 추출물의 총 피부 투과량은 에토좀(77.16%) > 리포좀(62.80%) > 에탄올 용액(41.59%) 순으로 나타났다. 결과적으로 0.05% 두충 추출물을 담지한 에토좀은 피부 전달에 효과적이며, 식물 추출물을 함유하는 화장품 제형으로서 사용 가능성이 있음을 시사한다.

Keywords

References

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