Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effect of Korean red ginseng extract on liver damage induced by shortterm and long-term ethanol treatment in rats

  • Seo, Su-Jeong (Department of Medical Biotechnology, College of Medical Biosciences, Kangwon National University) ;
  • Cho, Jae Youl (Department of Genetic Engineering, Sungkyunkwan University) ;
  • Jeong, Yeon Ho (Department of Medical Biotechnology, College of Medical Biosciences, Kangwon National University) ;
  • Choi, Yong-Soon (Department of Medical Biotechnology, College of Medical Biosciences, Kangwon National University)
  • Received : 2012.10.05
  • Accepted : 2012.11.26
  • Published : 2013.04.15
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Abstract

Korean red ginseng (KRG) is prepared by the process of steaming the roots of Panax ginseng. In this study, the feeding effects of KRG-water extract (KRGE) on ethanol-induced liver damage were elucidated by measuring serum biomarkers in rats. Serum ${\gamma}$-glutamyltranspeptidase (g-GT) activity and the concentration of malondialdehyde (MDA) were significantly increased by short-term and long-term ethanol treatment in rats, whereas the activities of serum glutamate pyruvate transaminase (GPT) and glutamate oxaloacetate transaminase (GOT) did not respond. Pretreatment with KRGE maintained the activity of serum GPT, and the MDA concentration induced by short-term ethanol ingestion remained within the normal range. However, co-feeding of KRGE to rats decreased the concentration of MDA but failed to modulate the serum ${\gamma}$-GT activity induced by long-term ethanol treatment. Our studies suggest that in rats, it appears that KRGE does not sufficiently reverse the physiological response evoked by long-term ethanol ingestion to maintain normal conditions, in view of the serum biomarker ${\gamma}$-GT, regardless of KRGE's favorable antioxidant activity.

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References

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