Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Influence of Isoflavone Intake and Equol-producing Intestinal Flora on Prostate Cancer Risk

  • Sugiyama, Yukiko (Department of Public Health, Sapporo Medical University School of Medicine) ;
  • Masumori, Naoya (Department of Urology, Sapporo Medical University School of Medicine) ;
  • Fukuta, Fumimasa (Department of Urology, Sapporo Medical University School of Medicine) ;
  • Yoneta, Akihiro (Department of Dermatology, Sapporo Medical University School of Medicine) ;
  • Hida, Tokimasa (Department of Dermatology, Sapporo Medical University School of Medicine) ;
  • Yamashita, Toshiharu (Department of Dermatology, Sapporo Medical University School of Medicine) ;
  • Minatoya, Machiko (Department of Public Health, Sapporo Medical University School of Medicine) ;
  • Nagata, Yoshie (Department of Public Health, Sapporo Medical University School of Medicine) ;
  • Mori, Mitsuru (Department of Public Health, Sapporo Medical University School of Medicine) ;
  • Tsuji, Hirokazu (Yakult Central Institute for Microbiological Research) ;
  • Akaza, Hideyuki (Research Center for Advanced Science and Technology, Tokyo University) ;
  • Tsukamoto, Taiji (Department of Urology, Sapporo Medical University School of Medicine)
  • Published : 2013.01.31
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Abstract

Background: The age-adjusted incidence rate of prostate cancer (PCa) has been reported to be lower among Asians than Western populations. A traditional Japanese meal, high in soybean products or isoflavones, may be associated with a decreased risk of PCa. Equol, which is converted from daidzein by human intestinal flora, is biologically more active than any other isoflavone aglycone. Materials and Methods: We reviewed not only recent epidemiological studies on association of isoflavones with PCa risk, but also recent research on human intestinal bacteria responsible for converting daidzein into equol. Studies were systematically searched from the database published within the last 5 years of from 2008-2012. Results: Five out of 6 articles showed significant association of isoflavones with a decreased risk of PCa, and two of them consistently showed that equol-producers carry a significantly reduced risk of PCa. Furthermore, 5 human intestinal bacteria that can convert daidzein into equol were identified in the last 5 years. Conclusions: If equol can reduce risk of PCa, a possible strategy for reducing the risk of PCa may be to increase the proportion of equol-producers by changing the intestinal flora to carrying an equol-producing bacterium with dietary alteration or probiotic technology.

Keywords

References

  1. Breinholt V, Larsen JC (1998). Detection weak estrogenic flavonoids using a recombinant yeast strain and modified MCF7 cell proliferation assay. Chem Res Toxicol, 11, 622-9. https://doi.org/10.1021/tx970170y
  2. Curado MP, Edwards B, Shin HR, et al (2007). Cancer Incidence in Five Continents. Vol. 9. IARC Scientific Publ. No. 160, IARC, Lyon.
  3. Jackson MD, McFarlane-Anderson ND, Simon GA, et al (2010). Urinary phytoestrogens and risk of prostate cancer in Jamaican men. Cancer Causes Control, 21, 2249-57. https://doi.org/10.1007/s10552-010-9648-9
  4. Jin JS, Kitahara, M, Sakamoto M, et al (2010). Slackia equolifaciens sp. nov. a human intestinal bacterium capable of producing equol. Int J System Evol Microbiol, 60, 1721-4. https://doi.org/10.1099/ijs.0.016774-0
  5. Kim M, Han J, Kim S (2008). Isoflavone daidzein: chemistry and bacterial metabolism. J Appl Chem, 51, 253-61. https://doi.org/10.3839/jabc.2008.040
  6. Kurahashi N, Iwasaki M, Inoue M, et al (2008). Plasma isoflavones and subsequent risk of prostate cancer in a nested case-control study: the Japan public health center. J Clin Oncol, 26, 5923-9. https://doi.org/10.1200/JCO.2008.16.8807
  7. Lund TD, Munson DJ, Haldy ME, et al (2004). Equol is a novel anti-androgen that inhibit prostate growth and hormone feedback. Biol Reprod, 70, 1188-95.
  8. Maruo T, Sakamoto M, Ito C, et al (2008). Adlercreutzia equolifaciens gen. nov. sp. nov. an equol-producing bacterium isolated from human faeces and emended description of the genus Eggertbella. Int J System Evol-Microbiol, 58, 1221-7. https://doi.org/10.1099/ijs.0.65404-0
  9. Matthies A, Blaut M, Braune A (2009). Isolation of a human intestinal bacterium capable of daidzein and genistein conversion. Appl Environ Microbiol, 75, 1740-4. https://doi.org/10.1128/AEM.01795-08
  10. Miyanaga N, Akaza H, Hinotsu S, et al (2012). Prostate cancer chemoprevention study: an investigative randomized control study using purified isoflavones in men with rising prostatespecific antigen. Cancer Sci, 103, 125-30. https://doi.org/10.1111/j.1349-7006.2011.02120.x
  11. Mori M, Masumori N, Fukuta F, et al (2009). Traditional Japanese diet and prostate cancer. Mol Nutr Food Res, 53, 191-200. https://doi.org/10.1002/mnfr.200800285
  12. Park SY, Murphy SP, Wilkens LR, et al (2008). Legume and isoflavone intake and prostate cancer risk: the multiethnic cohort study. Int J Cancer, 15, 927-32.
  13. Park SY, Wilkens LR, Franke AA, et al (2009). Urinary phytoestrogen excretion and prostate cancer risk: a nested case-control study in the multiethnic cohort. Br J Cancer, 101, 185-91. https://doi.org/10.1038/sj.bjc.6605137
  14. Setchell KDR, Brown NM, Lydeking-Olesen E (2002). The clinical importance of the metabolite equol-A clue to the effectiveness of soy and its isoflavones. J Nutr, 132, 3577-84.
  15. Setchell KDR, Clerici C (2010). Equol: history, chemistry, and formation. J Nutr, 140, 1355-62. https://doi.org/10.3945/jn.109.119776
  16. Travis RC, Spencer EA, Allen NE, et al (2009). Plasma phytooestrogens and prostate cancer in the European prospective investigation into cancer and nutrition. Br J Cancer, 100, 1817-23. https://doi.org/10.1038/sj.bjc.6605073
  17. Tsuji H, Moriyama K, Nomoto K, et al (2010). Isolation and characterization of the equol-producing bacterium Slackia sp. strain NATTS. Arch Microbiol, 192, 279-87. https://doi.org/10.1007/s00203-010-0546-z
  18. Tsuji H, Moriyama K, Nomoto K, et al (2012). Identification of an enzyme system for daidzein-to-equol conversion in Slackia sp. strain NATTS. Appl Environ Microbiol, 78, 1228-36. https://doi.org/10.1128/AEM.06779-11
  19. World Cancer Research Fund/ American Institute for Cancer Research (2007). Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective. American Institute for Cancer Research, Washington DC.
  20. Yokoyama S, Suzuki T (2008). Isolation and characterization of a novel equol-producing bacterium from human feces. Biosci. Biotechnol Biochem, 72, 2660-6. https://doi.org/10.1271/bbb.80329
  21. Yuan JP, Wang JH, Liu X (2007). Metabolism of dietary soy isoflavones to equol by human intestinal microfloraimplication for health. Mol Nutr Food Res, 51, 765-81. https://doi.org/10.1002/mnfr.200600262

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