Korean Journal of Chemical Engineering

The Korean Institute of Chemical Engineers (한국화학공학회)
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Enhanced transdermal deposition and characterization of quercetin-loaded ethosomes

  • Park, Soo Nam (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Lee, Hye Jin (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Kim, Hae Soo (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Park, Min A (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Gu, Hyun A (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology)
  • Received : 2012.06.29
  • Accepted : 2012.10.02
  • Published : 2013.03.01
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Abstract

We sought to evaluate the transdermal permeation potential of quercetin-loaded ethosomes. Quercetin-loaded ethosomes were prepared and characterized with regard to particle size, loading efficiency, stability, and in vitro skin permeation. The optimized formulation of ethosomes was confirmed using 2% egg phosphatidylcholine and hydrated 20% ethanol. After quercetin was applied using this formulation, the stability of the ethosomes was determined when loaded with up to 0.04% quercetin. We observed that loading efficiency was improved with increasing concentrations of quercetin. Ethosomes loaded with 0.04% quercetin showed both the greatest loading efficiency ($63.9%{\pm}6.0%$) and an optimal size range ($132{\pm}32$ nm). Ethosomes loaded with quercetin were superior in skin permeation ability ($29.5{\pm}7.0{\mu}g/cm^2$) compared to either ethanolic solution or liposomes. Therefore, we concluded that quercetin-loaded ethosomes increased the skin delivery of quercetin. Our results suggest that quercetin-loaded ethosomes may enhance the effect of cosmetic materials.

Keywords

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