The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Anti-diabetic effect of medicinal plants used for lower wasting-thirst in streptozotocin-induced diabetic rats

Streptozotocin으로 유도된 당뇨 흰쥐에서 하소에 사용되는 한약의 항당뇨 효과 비교 연구

  • Oh, Tae Woo (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
  • Kang, Seok Yong (Department of Herbology, College of Oriental Medicine, Dongguk University) ;
  • Kim, Kyung Ho (Department of Acupuncture, Dongguk University Gyeongju Oriental Hospital) ;
  • Song, Mi-Young (Department of Rehabilitation Medicine of Korean Medicine, Dongguk University Gyeongju Oriental Hospital) ;
  • Park, Yong-Ki (Department of Herbology, College of Oriental Medicine, Dongguk University)
  • 오태우 (동국대학교 한의과대학 본초학교실) ;
  • 강석용 (동국대학교 한의과대학 본초학교실) ;
  • 김경호 (동국대학교 경주한방병원 침구과) ;
  • 송미영 (동국대학교 경주한방병원 재활의학과) ;
  • 박용기 (동국대학교 한의과대학 본초학교실)
  • Received : 2013.08.22
  • Accepted : 2013.09.23
  • Published : 2013.09.30
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Abstract

Objectives : To prove the channel-tropism theory in herbology, we investigated the anti-diabetic effect of six herbal plants used for lower wasting-thirst in streptozotocin-induced diabetic rats. Methods : Diabetes was induced in male Sprague-Dawley rats by consecutive injection of streptozotocin (30 mg/kg i.p.) for 5 days. The rats were divided into normal control, diabetic control, and diabetic treatment with Lycii Radicis Cortex (LRC, 300 mg/kg); Corni Fructus (CF, 300 mg/kg); Bombyx Batryticatus (BB, 50 mg/kg); Lycii Fructus (LF, 300 mg/kg); Phellodendri Cortex (PC, 300 mg/kg); Epimedii Herba (EH, 300 mg/kg); and glibenclimide (10 mg/kg) as a reference drug. Herbal extracts or reference drug were administered orally for 28 days. The changes of body weight, food intake and water intake, and serological markers such as blood glucose, serum total cholesterol, triglyceride (TG), blood urea nitrogen (BUN), and creatinine (Cr) were measured. Results : The decrease of body weight and the increase of food and water intake in STZ-induced diabetic rats was improved by the administration of CF and LF. Also, the enhancement of blood glucose and serum total cholesterol, TG, BUN and Cr in STZ-induced diabetic rats was significantly inhibited by the administration of CF, BB, LF and glibenclimide. On the other hand, EH strongly inhibited the increase of BUN and Cr in the sera of STZ-induced diabetic rats. Conclusions : These results suggest that among six herbal medicines used lower emaciation of emaciation-thirst disease, CF, BB, LF and EH show a characteristics including the channel-tropism theory.

Keywords

References

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