The Korean Journal of Health Service Management (보건의료산업학회지)

Korea Society of Health Service Management (보건의료산업학회)
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Correlation between Arterial Stiffness and Physiological Parameters

동맥경화도와 생리학적 변수들 간의 상관관계

  • Shin, Jae-Wook (Department of Clinical Laboratory Science, Catholic University of Pusan) ;
  • Seok, Seong-Ja (Department of Clinical Pathology, Sorabol College) ;
  • Lee, Gil-Hyun (Department of Clinical Laboratory Science, Catholic University of Pusan) ;
  • Choi, Seok-Cheol (Department of Clinical Laboratory Science, Catholic University of Pusan) ;
  • Hyun, Kyung-Yae (Department of Clinical Laboratory Sciense, Dong-Eui University)
  • 신재욱 (부산가톨릭대학교 임상병리학과) ;
  • 석성자 (서라벌대학교 임상병리학과) ;
  • 이길현 (부산가톨릭대학교 임상병리학과) ;
  • 최석철 (부산가톨릭대학교 임상병리학과) ;
  • 현경예 (동의대학교 임상병리학과)
  • Received : 2013.07.16
  • Accepted : 2013.08.11
  • Published : 2013.09.30
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Abstract

Arterial stiffness(AS) is an important pathologic state of vascular injury. This study was carried out to elucidate the effect of physiological variables on brachial-ankle pulse wave velocity(BAPWV), index of AS. Four hundred adults(volunteers) participated in this study. Body indices, biochemical, cardiac and inflammatory markers, and right(Rt)- and left(Lt)-BAPWV were measured. Body mass index(BMI), Rt- and Lt-BAPWV, glucose, triglyceride, alkaline phosphatase(ALP), gamma-glutamyl transferase(GGT), creatinine, uric acid, troponin-I(TNI), NT-proBNP and high sensitivity C-reactive protein(hs-CRP) levels were higher than the reference value of each variable. Rt- and Lt-BAPWV were directly correlated with age, body weight, BMI, glucose, ketone, aspartate aminotransferase, alanine aminotransferase, ALP, GGT, total cholesterol, low density lipoprotein, lipoprotein(a), apolipoprotein-B, blood urea nitrogen, heart rate, TNI, creatine kinase, CK-MB, lactic dehydrogenase, myoglobin, hs-CRP, lipase, reumatoid factor, fibrinogen and D-dimer (P<0.05, P<0.01, P<0.001 or P<0.000, respectively), but inversely associated with total bilirubin, uric acid, apolipoprotein-A1 and GFR (P<0.05). These observations suggest that a variety of physiological variables may influence BAPWV, resulting in increased risk or prevention of cardiovascular and/or cerebrovascular attacks. Therefore, physiological variables affecting BAPWV should be regularly controlled.

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References

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