Korean Journal of Chemical Engineering

The Korean Institute of Chemical Engineers (한국화학공학회)
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Enhanced skin delivery and characterization of rutin-loaded ethosomes

  • Park, Soo Nam (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Lee, Hye Jin (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology) ;
  • Gu, Hyun A (Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology)
  • Received : 2013.07.31
  • Accepted : 2013.10.30
  • Published : 2014.03.01
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Abstract

We formulated rutin-loaded ethosomes and compared their vesicle size, loading efficiency, stability, and elasticity. In addition, an in vitro skin penetration experiment was performed. The results of the study indicated that ethosomes loaded with 0.005-0.03% rutin were stable during the four-week study period. Among them, those loaded with 0.03% rutin showed a vesicle size ($190.20{\pm}14.57nm$) and loading efficiency ($73.77%{\pm}0.01%$). Therefore, the in vitro skin penetration experiment was performed using 0.03% rutin-loaded ethosome. Compared to an ethanolic solution of rutin (44.16%), rutin-loaded liposome (37.80%), and a distilled water (DW) solution of rutin (18.31%), rutin-loaded ethosome ($93.31{\mu}g$; 61.30%) was superior in delivering rutin. Therefore, we suggest that ethosome loaded with 0.03% rutin enhance the skin penetration of rutin and may be used as a drug delivery system for natural cosmetic materials such as flavonoids.

Keywords

References

  1. H. J. Lee, and S. N. Park, J. Soc. Cosmet. Scientists Korea, 37(2), 143 (2011).
  2. H. J. Yang, Y. J. Ahn, J. H. Kim and S. N. Park, J. Soc. Cosmet. Scientists Korea, 34(3), 189 (2008).
  3. J. E. Kim, W.Y. Kim, J.W. Kim, H. S. Park, S.H. Lee, S.Y. Lee, M. J. Kim, A. R. Kim and S. N. Park, J. Soc. Cosmet. Scientists Korea, 36(4), 303 (2010).
  4. S. N. Park, S.Y. Kim, G. N. Lim, N. R. Jo and M. H. Lee, J. Ind. Eng. Chem., 18, 680 (2012). https://doi.org/10.1016/j.jiec.2011.11.126
  5. H. Luo, B. H. Jiang, S.M. King and Y.C. Chen, Nutrition and Cancer, 60(6), 800 (2008). https://doi.org/10.1080/01635580802100851
  6. M. Diana, K. Agata and K. Stefan, IUBMB Life, 41, 1067 (1997). https://doi.org/10.1080/15216549700202141
  7. J. L. Kwang and H.R. Kyung, Korean J. Chem. Eng., 23(5), 779 (2006). https://doi.org/10.1007/BF02705927
  8. Z. Antonio and L. Roberto, Korean J. Chem. Eng., 28(10), 1965 (2011). https://doi.org/10.1007/s11814-011-0083-8
  9. M. S. Lim, M.A. Park, S. S. Kwon and S. B. Han, Polymer (Korea), 36, 705 (2012).
  10. K.Y. Choi, K.H. Min, J. H. Park, K. M. Kim and S.Y. Jung, Polym. Sci. Technol., 20(3), 216 (2009).
  11. B. S. Jin, Y. M. Han, K.H. Lee and M. J. Cho, J. Korean Ind. Eng. Chem., 15, 205 (2004).
  12. S. K. Bae, J.C. Kim, U. K. Jee and J. D. Kim, Korean J. Chem. Eng., 16(1), 56 (1999). https://doi.org/10.1007/BF02699005
  13. H. J. Gwak and B. S. Jin, J. Korean Ind. Eng. Chem., 18, 130 (2007).
  14. E. J. An, C. K. Kang, J.W. Kim and B. S. Jin, KIC News, 13(4), 24 (2010).
  15. M.M. A. Elsayed, O.Y. Abdallah, V. F. Naggar and N. M. Khalafallah, Int. J. Pharm., 332, 1 (2007). https://doi.org/10.1016/j.ijpharm.2006.12.005
  16. J. E. Kim, H. J. Lee, M. S. Lim, M. A. Park and S. N. Park, J. Soc. Cosmet. Scientists Korea, 38(1), 15 (2012).
  17. M. S. Lim, S. B. Han, S. S. Kwon, M.A. Park and S. N. Park, J. Soc. Cosmet. Scientists Korea, 38(2), 147 (2012).
  18. S. N. Park, M. H. Lee, S. J. Kim and E. R. Yu, BBRC, 435, 361, (2013).
  19. E. Touitou, N. Dayan, L. Bergelson, B. Godin and M. Eliaz, J. Control. Release, 65, 403 (2000). https://doi.org/10.1016/S0168-3659(99)00222-9
  20. E. Touitou, B. Godin and C. Weiss, Drug Dev. Res., 50, 406 (2000). https://doi.org/10.1002/1098-2299(200007/08)50:3/4<406::AID-DDR23>3.0.CO;2-M
  21. V. Dubey, D. Mishra, T. Dutta, M. Nahar, D. K. Saraf and N. K. Jain, J. Control. Release, 123, 148 (2007). https://doi.org/10.1016/j.jconrel.2007.08.005
  22. Y. P. Fang, Y.H. Tsai, P. C. Wu and Y.B. Huang, Int. J. Pharm., 356, 144 (2008). https://doi.org/10.1016/j.ijpharm.2008.01.020
  23. D. Paolino, G. Lucania, D. Mardente, F. Alhaique and M. Fresta, J. Control. Release, 106, 99 (2005). https://doi.org/10.1016/j.jconrel.2005.04.007
  24. Y. P. Fang, Y. B. Huang, P. C. Wu and Y. H. Tsai, Eur. J. Pharm. Biopharm., 73, 391 (2009). https://doi.org/10.1016/j.ejpb.2009.07.011
  25. M. Maria, C. Caddeo, C. Sinico, D. Valenti, M. C. Mostallino, G. Biggio and A.M. Fadda, Eur. J. Pharm. Biopharm., 78, 27 (2011). https://doi.org/10.1016/j.ejpb.2010.12.010
  26. S. Jain, A.K. Tiwary, B. Sapra and N.K. Jain, AAPS PharmSciTech., 8, E1 (2007).
  27. S. Jain, P. Jain and N. K. Jain, Drug Dev. Ind. Pharm., 29, 1013 (2003). https://doi.org/10.1081/DDC-120025458
  28. S. N. Park, H. J. Lee, H. S. Kim, M. A. Park and H. A. Gu, Korean J. Chem. Eng., 30, 688 (2013). https://doi.org/10.1007/s11814-012-0171-4
  29. S. Osanai and K. Nakamura, Biomaterials, 21, 9 (2000). https://doi.org/10.1016/S0142-9612(99)00127-1

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