Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
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Effects of Agastache rugosa on Obesity Via Inhibition of Peroxisome Proliferator-Activated Receptor-Gamma and Reduction of Food Intake

지방합성 인자 조절 및 식이 섭취 감소를 통한 곽향의 항비만 효능

  • Kim, Young Min (Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Mi Hye (Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University) ;
  • Yang, Woong Mo (Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University)
  • 김용민 (경희대학교 한의과대학 융합한의과학교실) ;
  • 김미혜 (경희대학교 한의과대학 융합한의과학교실) ;
  • 양웅모 (경희대학교 한의과대학 융합한의과학교실)
  • Received : 2015.10.23
  • Accepted : 2015.11.30
  • Published : 2015.12.30
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Abstract

Objectives: The herb of Agastache rugosa (AR) is a traditional herbal medicine used for colds, vomiting and furuncles. However, there are few reports to investigate the inhibitory effects of AR on obesity. In this study, the effects of AR on high fat diet (HFD)-induced obesity and its mechanism of actions were investigated in experimental animals. Methods: The mice were fed HFD for 4 weeks to induce obesity. After randomly divided into normal fat diet, HFD and AR groups, 200 mg/kg of AR was administrated for 4 weeks with continuous HFD feeding while vehicle was orally treated to HFD group. Food intake and body weight were recorded weekly. Results: Increased body weight by HFD was improved by AR treatment. AR administration inhibited an increase of visceral fat weight as well as adipocyte hypertrophy. Hepatic steatosis was ameliorated in AR-treated mice. In addition, treatment of AR attenuated the expression of adipogenic transcription factor, peroxisome proliferator-activated receptor (PPAR)-gamma in the epididymal adipose tissue. Also the increased serum leptin level by HFD was maintained in AR group, leading to inhibition of food intake. Conclusions: AR treatment showed inhibitory effects on HFD-induced obesity by inhibition of PPAR-gamma and reduction of food intake. AR could be an alternative treatment for obesity.

Keywords

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