Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Epidemiological Study of Laryngeal Carcinoma in Western Nepal

  • Koirala, Krishna (Otolaryngology and Head and Neck Department, Manipal Teaching Hospital)
  • Published : 2015.10.06
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Abstract

Background: Laryngeal malignancy is a common malignancy of the head and neck region. Affected patients usually present with features that are characteristic of certain subsites. The larynx is oncologically divided into three: supraglottis, glottis and subglottis. Studies from Western countries have shown that the glottis is the commonest subsite to harbour laryngeal malignancy. However, the supraglottis has been reported to be the commonest subsite in developing countries, including examples in the Indian subcontinent. To our knowledge, no study has been carried out in western Nepal about the epidemiology of laryngeal cancer to date. The purpose of this study was to analyse the epidemiology of laryngeal cancer in relation to its risk factors, age distribution,and preferred subsites and to see if there is any recent change in the subsite wise distribution of laryngeal malignancy in western Nepal. Materials and Methods: Patients of all ages and both sexes with suspected laryngeal malignancy were enrolled in the initial study. Detailed history taking and clinical examination was performed to find out the involved subsite in relation to the clinical features. Direct laryngoscopy was performed to further confirm the subsite and to take biopsy from the growth under general anesthesia. After confirmation of malignancy from the biopsy report, patients were finally included in the study. Data were analysed and observations were made to find out the distribution of laryngeal malignancy in different subsites. Results: The supraglottic larynx was the commonest subsite to harbor laryngeal malignancy. Smoking and alcohol were found to be the common risk factors. The mean age of the patients was in their sixties. Conclusions: Laryngeal malignancy is common in elderly individuals. Supraglottic laryngeal malignancy is the commonest laryngeal malignancy in people who smoke and drink alcohol in Nepal. Avoidance of alcohol use and smoking will be a milestone to reduce the incidence of laryngeal cancers and associated mortality.

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References

  1. Akmansu SH, Korkmaz H, Dursun E, et al (1999). Clinical and histopathological indicators of Neck metastasis in laryngeal carcinoma. Tr J Med Sci, 29, 313-17.
  2. Babak S, Ebrahim R, Mohammad S, et al (2009). The epidemiology of laryngeal cancer in a country on the esophageal cancer belt. Indian Journal of Otolaryngology and Head & Neck Surgery, 61, 213-17. https://doi.org/10.1007/s12070-009-0069-6
  3. Bhattacharyya T, Dhanireddy B, Ghoshal S, et al (2014). Efficacy of radical radiotherapy alone for functional preservation of larynx in laryngeal carcinoma: A retrospective analysis. Indian Journal of Cancer, 51, 10-14. https://doi.org/10.4103/0019-509X.134600
  4. Chu EA, Young JK, (2008). Laryngeal cancer: diagnosis and work up. Otolaryngol Clin N Am, 41, 673-95. https://doi.org/10.1016/j.otc.2008.01.016
  5. Gul K, Ozgur E, Akmansu M, et al (2015). HPV-Associated p16 INK4A expression and response to therapy and survival in selected head and neck cancers. Asian Pac J Cancer Prev, 16, 253-58. https://doi.org/10.7314/APJCP.2015.16.1.253
  6. Gupta B, Johnson N W (2014). Emerging and established global life-style risk factors for cancer of the upper aero-digestive tract. Asian Pacific J Cancer Prev, 15, 5983-91. https://doi.org/10.7314/APJCP.2014.15.15.5983
  7. Jaimanti B, Naresh K. Panda, (2004). Survival patterns in treated patients of carcinoma larynx in North India. Indian Journal of ORL, 56, 99-103.
  8. Jukka A V, Pasi P H, Eero J K, et al (2000). Is the Subsite Distribution of laryngeal cancer related to smoking habits? Acta Oncologica, 39, 77-79. https://doi.org/10.1080/028418600431012
  9. Koirala K, Sharma V (2013). Laryngeal malignancy: relation of tumor size and neck node metastasis. Nepal J Medical Sciences, 2, 48-51.
  10. Kowit P , Sumet P, Vitoon L, et al (2012). Survival and prognostic factors of different sites of head and neck cancer: an analysis from Thailand. Asian Pacific J Cancer Prev, 13, 885-90. https://doi.org/10.7314/APJCP.2012.13.3.885
  11. Kwang M K, Young M K , Yoonsang S, et al (2003). Epidemiological survey of Head and Neck Cancers in Korea. J Korean Med Sci, 18, 80-87. https://doi.org/10.3346/jkms.2003.18.1.80
  12. Lasrado S, Prabhu P, Kakria A, et al (2012). Clinicopathological profile of head and neck cancers in the western development region, Nepal: A 4-Year Snapshot. Asian Pacific J Cancer Prev, 13, 6059-62. https://doi.org/10.7314/APJCP.2012.13.12.6059
  13. Mohanty BK, Bahadur S, Lal P (2002). Textbook of Radiation oncology-Principles and Practice, Elsevier, New Delhi, p162-3.
  14. Negar M, Maryam K, Niloufar H, et al (2012). Head and neck squamous cell carcinoma in Iranian patients and risk factors in young adults: a fifteen-year study. Asian Pacific J Cancer Prev, 13, 3373-78. https://doi.org/10.7314/APJCP.2012.13.7.3373
  15. Owen Pyeko M, Patel A, Ouma Oburra H (2014). Demography and histologic pattern of laryngeal squamous cell carcinoma in Kenya. International Journal of Otolaryngology, 2014.
  16. Patel Urjeet A, Lynn-Macrae A, Rosen F, et al (2006). Advanced stage of head and neck cancer at a tertiary-care county hospital. Laryngoscope, 116, 1473-77. https://doi.org/10.1097/01.mlg.0000227448.71894.8c
  17. Raquel F M, Anke B, Luiz C, et al (2013). Alcohol consumption and risk of cancer: a systematic literature review. Asian Pac J Cancer Prev, 14, 4965-72. https://doi.org/10.7314/APJCP.2013.14.9.4965
  18. Siddiqui S M, Chandra R, Abdul A, et al (2012). Epidemiology and histopathological spectrum of head and neck cancers in bihar, a state of eastern India. Asian Pac J Cancer Prev, 13, 3949-53. https://doi.org/10.7314/APJCP.2012.13.8.3949
  19. Thapa NM, Jha A.K., Rijal J P (2003). Study on head and neck tumors presented in ENT OPD of Nepal Medical College Teaching Hospital. NMC Journal, 5, 79-81.
  20. Yoke Fui W, Mastura M Y, Wan Zamaniah W I, et al (2015). Treatment outcome for head and neck squamous cell carcinoma in a developing country: university Malaya medical centre, Malaysia from 2003-2010. Asian Pac J Cancer Prev, 16, 2903-08. https://doi.org/10.7314/APJCP.2015.16.7.2903

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