Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Effect of Roasted Water Extract of Fermented Cassia tora L. by Lactobacillus casei on the Loperamide-Induced Constipation Model in Rats.

Loperamide로 유도된 변비모델에서 Lactobacillus casei에 의해 발효된 볶은 결명자 물 추출물의 효과

  • Nho, Jong Hyun (National Development Institute of Korean Medicine) ;
  • Jung, Ho Kyung (National Development Institute of Korean Medicine) ;
  • Lee, Mu Jin (National Development Institute of Korean Medicine) ;
  • Jang, Ji Hun (National Development Institute of Korean Medicine) ;
  • Sim, Mi Ok (National Development Institute of Korean Medicine) ;
  • Jung, Ja Kyun (National Development Institute of Korean Medicine) ;
  • Lee, Ki Ho (National Development Institute of Korean Medicine) ;
  • An, Byeong Kwan (National Development Institute of Korean Medicine) ;
  • Cho, Jung Hee (National Development Institute of Korean Medicine) ;
  • Jang, Min Cheol (Heanam Natural Farming Association Corporation) ;
  • Yong, Ju Hyun (Heanam Natural Farming Association Corporation) ;
  • Cho, Hyun Woo (National Development Institute of Korean Medicine)
  • Received : 2016.10.26
  • Accepted : 2016.12.21
  • Published : 2016.12.30
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Abstract

Background: Constipation is one of the most common functional gastrointestinal disorder. The present study examined the ability of water extract of fermented (FRC) and non-fermented (NFRC) roasted Cassia tora to improve intestinal function and reduce constipation in a rat constipation model. Methods and Results: Different concentration of FRC and NFRC were orally administered loperamide (5 mg/kg; LOP) reduced the number, weight, and water content of feces, as well as intestinal transit motility. However, 24 h-(24 hour fermented roasted-Cassia tora) 300 mg/kg FRC administration increased the number, weight, and water concent of feces, compared to that seen in the LOP group, and also improve intestinal transit mitility and, the thickness of distal colon and mucous fluid. Conclusions: The results of the present study indicated that LOP-induced constipation was improved by treatment with FRC. Therefore FRC could be used to develop functional foods or natural medicine for constipation. However, further study is needed to clarify how fermentation improves the medicinal properties of roasted C. tora.

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References

  1. Aichbichler BW, Wenzl HH, Santa Ana CA, Porter JL, Schiller LR and Fordtran JS. (1998). A comparison of stool characteristic from normal and constipated people. Digestive Diseases and Sciences. 43:2353-2362. https://doi.org/10.1023/A:1026699525487
  2. Camilleri M. (2001). Management of the irritable bowel syndrome. Gastroenterology. 120:652-668. https://doi.org/10.1053/gast.2001.21908
  3. Choi MK. (2005). Review: Evidence based guideline for diagnosis and treatment: Diagnostic guideline for constipation. Korean Journal of Neurogastroenterology Motility. 11:44-50.
  4. Ha JH, Jeong MH, Seo YC, Choi WY, Kim JS, Kim HH, Ahn JH and Lee HY. (2010). Enhancement of antioxidant activities of bark of Berberis koreana palibin by lactic acid fermentation. Korean Journal of Medicinal Crop Science. 18:421-428.
  5. Holzer P. (2007). Treatment of opioid-induced gut dysfunction. Expert Opinion on Investigational Drugs. 16:181-194. https://doi.org/10.1517/13543784.16.2.181
  6. Holzer P. (2009). Opioid receptors in the gastrointestinal tract. Regulatory Peptides. 155:11-17. https://doi.org/10.1016/j.regpep.2009.03.012
  7. Hong KH, Choi WH, Ahn JY, Jung CH and Ha TY. (2012a). Physicochemical properties of ethanol extracts and dietary fiber from Cassia tora L. seed. The Korean Journal of Food and Nutrition. 25:612-619. https://doi.org/10.9799/ksfan.2012.25.3.612
  8. Hong KH, Um MY, Ahn JY and Ha TY. (2012b). Effect of Cassia tora extracts on D-galactosamine-induced liver injury in rats. The Korean Journal of Food and Nutrition. 25:546-553. https://doi.org/10.9799/ksfan.2012.25.3.546
  9. Jang JH, Jung HK, Sim MO, An BK, Kim MS, Kang BM, Cho JH, Bean CG, Kim SC and Jung WS. (2016). Effect of Dendrobium speciosum var. aqueous extract on loperamideinduced constipation in rats. Korean Journal of Medicinal Crop Science. 24:1-6. https://doi.org/10.7783/KJMCS.2016.24.1.1
  10. Jung HK. (2001). Selection criteria for probiotics and their industrial applications. Bioindustry News. 14:39-48.
  11. Jun DW, Park HY, Lee OY, Lee HL, Yoon BC, Choi HS, Hahm JS, Lee MH, Lee DH and Kee CS. (2006). A population-based study on bowel habits in a Korean community: Prevalence of functional constipation and self-reported constipation. Digestive Diseases and Sciences. 51:1471-1477. https://doi.org/10.1007/s10620-006-9087-3
  12. Jung SJ. (2011). The importance of nutritional assessment and dietary counseling in infants and young children with common illnesses. Korean Journal Pediatric Gastroenterology and Nutrition. 14:33-44. https://doi.org/10.5223/kjpgn.2011.14.1.33
  13. Kakino M, Tazawa S, Maruyama H, Tsuruma K, Araki Y, Shimazawa M and Hara H. (2010). Laxative effects of agarwood on low-fiber diet-induced constipation in rats. BMC Complementary and Alternative Medicine. 10:68-68. https://doi.org/10.1186/1472-6882-10-68
  14. Kim JM, Kim HT and Hwang SM. (1990). Instant tea preparation from Cassia tora seeds. Korean Journal of Food Science and Technology. 22:241-247.
  15. Kim JK, Hawer WD, Ha JH, Moon KD and Chung SK. (1995). Changes of volatile flavor components on roasting conditions in Cassia tora seeds. Korean Journal of Food Science and Technology. 27:736-741.
  16. Kim YG, Bang JK, Yu HS, Lee ST and Park JS. (1997). Effects of planting density on growth and yield in Cassia obtusifolia. L. Korean Journal of Medicinal Crop Science. 5:95-101.
  17. Kim CH, Kwon MC, Kim HS, Bae GJ, Ahn JH, Choi GP, Choi YB, Ko JR and Lee HY. (2007). Enhancement of immune activities of Kadsura japonica Dunal. through conventional fermentation process. Korean Journal of Medicinal Crop Science. 15:162-169.
  18. Kim TH, Son YK, Hwang KH and Kim MH. (2008). Effects of Angelica keiskei Koidzumi and turmeric extract supplementation on serum lipid parameters in hypercholesterolemic diet or P-407-induced hyperlipidemic rats. Journal of the Korean Society of Food Science and Nutrition. 37:708-713. https://doi.org/10.3746/jkfn.2008.37.6.708
  19. Kim DG, Jin YG, Jin JY, Kim SC, Kim SC, Han CH and Lee YJ. (2011). Effects of the Actindia chinensis on loperamide-induced constipation in rat. Korean Journal of Plant Resources. 24:61-68. https://doi.org/10.7732/kjpr.2011.24.1.061
  20. Kim NY, Park DS and Lee HY. (2015). Effect of anti-skin wrinkle and antioxidant of Agastache rugosa Kentz through fermentation process of the lactic acid. Korean Journal of Medicinal Crop Science. 23:37-42. https://doi.org/10.7783/KJMCS.2015.23.1.37
  21. Kirchhoff PM, Biehl B, Ziegeler-Berghausen H, Hammoor M and Lieberei R. (1989). Kinetics of the formation of free amino acids in cocoa seeds during fermentation. Food Chemistry. 34:161-179. https://doi.org/10.1016/0308-8146(89)90137-4
  22. Lee MH, Cho JH and Kim BK. (2013). Effect of roasting conditions on the antioxidant activities of Cassia tora L. Korean Journal of Food Science and Technology. 45:657-660. https://doi.org/10.9721/KJFST.2013.45.5.657
  23. Ling J, Kim JS, Seo YC, Choi WY, Ahn JH, Ma CJ, Yoon CS and Lee HY. (2011). The effect of extracts of Berberis koreana bark by Lactobacillus fermentation on the concentration of serotonin and melatonin in the serum of treated ICR mice. Korean Journal of Medicinal Crop Science. 19:117-125. https://doi.org/10.7783/KJMCS.2011.19.2.117
  24. Loeschke K, Schmid T and Farack UM. (1989). Inhibition by loperamide of mucus secretion in the rat colon in vivo. European Journal of Phamacology. 170:41-46. https://doi.org/10.1016/0014-2999(89)90131-3
  25. Parson WT and Cuthbertson EG. (2001). Noxious weeds of Australia. CSIRO Publishing. Melbourne. VIC, Australia. p.265-298.
  26. Patil UK, Saraf S and Dixit VK. (2004). Hypolipidemic activity of seeds of Cassia tora Linn. Journal of Ethnopharmacology. 90:249-252. https://doi.org/10.1016/j.jep.2003.10.007
  27. Seo JH and Lee H. (2007). Characteristics and immunomodulating activity of lactic acid bacteria for the potential probiotics. Korean Journal of Food Science and Technology. 39:681-687.
  28. Wood JD and Galligan JJ. (2004). Function of opioids in the enteric nervous system. Neurogastroenterology and Motility. 16:17-28. https://doi.org/10.1111/j.1743-3150.2004.00554.x
  29. Yang MC, Kim DS, Jeong SW and Ma JY. (2011). Bioconversion constituents of galgeun-tang fermented by Lactobacillus plantarum. Korean Journal of Medicinal Crop Science. 19:446-455. https://doi.org/10.7783/KJMCS.2011.19.6.446