Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Analysis for Compatibility of Gyejibongnyeong-hwan and Its Biological Activities

계지복령환(桂枝茯苓丸)의 배오(配伍)분석과 그 생리활성

  • Kim, Do Hoy (Department of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-eui University) ;
  • Jung, Yang Sam (Jungyangsam Oriental Medical Clinic) ;
  • Yoon, Michung (Division of Medical Engineering and Health Management, Mok-Won University) ;
  • Yoon, Yoosik (Department of Microbiology, College of Medicine, Chung-Ang University) ;
  • Shin, Soon Shik (Department of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-eui University)
  • 김도회 (동의대학교 한의과대학 방제학교실 및 한방당뇨비만연구소) ;
  • 정양삼 (정양삼한의원) ;
  • 윤미정 (목원대학교 의생명.보건학부) ;
  • 윤유식 (중앙대학교 의과대학 미생물학교실) ;
  • 신순식 (동의대학교 한의과대학 방제학교실 및 한방당뇨비만연구소)
  • Received : 2016.11.13
  • Accepted : 2016.11.24
  • Published : 2016.11.30
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Abstract

Objectives : We analysed Gyejibongnyeong-hwan's compatibility principle and investigated biological activities by categorizing with molecular level, cellular level, animal level and human level based on Korean study for this formula. Methods : Gyejibongnyeong-hwan's compatibiltity principle was examined by the system of chief, deputy, assistant, and envoy. We looked into studies that presented in Korea from 1956 to 2016 about Gyejibongnyeong-hwan through Korea Institute of Oriental Medicine, Korean medicine information system (OASIS). Then classify into molecular level, cellular level, animal level and human level to analyse. Results : According to the system of chief, deputy, assistant, and envoy, chief herb is Cinnamomi Ramulus, deputy herb is Persicae Semen, assistant herb is Moutan Cortex, Paeoniae Radix, Poria, and envoy herb is Mel. Biological activities can be detected in transcription factors, enzymes, and inflammatory mediators for molecular level. For cellular level, it can be determined in human uterine endometrial cancer cell, human hepatocarcinoma cell, and human platelets. In mouse and rats for animal level, in overian cystoma, menorrhalgia, quality of life improvement in postmenopausal women, and blood stasis with motor vehicle accident for human level, biological activities was caught. Conclusions : From above results, Gyejibongnyeong-hwan is composed in line with the system of chief, deputy, assistan, and envoy. Biological activities are effective to improvement of menorrhalgia, anti-cancer, anti-oxidative, anti-inflammation, improvement of atherosclerosis, analgesic, anti-convulsion, wound healing, and improvement of liver function.

Keywords

References

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