DOI QR코드

DOI QR Code

Effect of Young Barley Leaf Powder on Glucose Control in the Diabetic Rats

보리순 분말이 당뇨쥐의 혈당조절에 미치는 효과

  • 손희경 (조선대학교 식품영양학과) ;
  • 이유미 (조선대학교 식품영양학과) ;
  • 박용현 (조선대학교 식품영양학과) ;
  • 이재준 (조선대학교 식품영양학과)
  • Received : 2015.12.03
  • Accepted : 2016.01.18
  • Published : 2016.02.29

Abstract

This study examined the anti-diabetic effects of young barley leaf powder in rats with streptozotocin (STZ)-induced diabetes. Male Sprague-Dawley rats were divided into the non-diabetic (N) and diabetic groups, and fed the following for four weeks. The diabetic groups were further subdivided into three experimental groups: a diabetic control group (STZ), a diabetic group fed 5% barley leaf powder (STZ-BL), and a diabetic group fed 10% barley leaf powder (STZ-BH). Food and water intakes were higher in the diabetic groups than in the N group. Body weight gain was higher in the STZ-BL and STZ-BH groups compared with the STZ group, but there were no significant changes in body weight gain between the diabetic groups. The serum glucose and fructosamine levels were lower in the STZ-BL and STZ-BH groups than in the STZ group. The levels of serum insulin were higher in the STZ-BL and STZ-BH groups than in the STZ group. Serum ALT, AST and ALP activities decreased in the STZ-BL and STZ-BH groups compared with the STZ group, but there was no difference. These results indicate that dietary supplementation of barley leaf powder can attenuate clinical symptoms of diabetes in rats with STZ-induced diabetes.

Keywords

References

  1. Adeghate E. Parvez SH(2000) Nitric oxide and neuronal and pancreatic beta cell death. Toxicol 153(1-3), 143-156 https://doi.org/10.1016/S0300-483X(00)00310-3
  2. Cho JS, Kim HY(2014) Quality characteristics of muffins by the addition of dried barley sprout powder. Korean J Food Cook Sci 30(1), 1-10 https://doi.org/10.9724/kfcs.2014.30.1.001
  3. Han HK, Lim SJ(1998) Effects of fractions from methanol extract of Commelina communis on blood glucose levels energy metabolism in streptozotocin-induced diabetic rats. Korean J Soc Food Sci 14(5), 577-583
  4. Han SY (2011) Antioxidative effects of the extract from barley sprout and application of the extracts to an edible oil and fat. MS Thesis. Chonbuk National University, Korea
  5. Hunt JV, Smith CC T, Wolff SP(1990) Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes 39(11), 1420-1424 https://doi.org/10.2337/diab.39.11.1420
  6. Jang JH, Choi HS, Cheong HS, Kang OJ(2007) A comparison of the antioxidant activity of barly leaf tea and green tea according to leaching conditions in distilled water. Korean J Food Cookery Sci 23(2), 165-172
  7. Jeong JJ, Kim YT, Seo WS, Yang HY, Lee YS, Cha JY(2006) Hypoglycemic and hepatoprotective effects of betaine on streptozotocin-induced diabetic rats. J Life Sci 16(5), 767-772 https://doi.org/10.5352/JLS.2006.16.5.767
  8. Johnson RN, Metcalf PA, Baker JR(1982) Fructosamine : a new approach to the estimation of serum glycosylprotein. An index of diabetic control. Clin Chim Acta 127(1), 87-95 https://doi.org/10.1016/0009-8981(83)90078-5
  9. Jung HS, Noh KH, Cho HY, Park JY, Choi CY, Kwon TW, Song YS(2003) Effect of buchu(Allium tuberosum) on lipid peroxidation and antioxidative defense system in streptozotocin-induced diabetic rats. Korean J Life Sci 13(3), 333-342 https://doi.org/10.5352/JLS.2003.13.3.333
  10. Kim IS, Han SH, Han KW(1997) Study on the chemical change of amino acid and vitamin of rapeseed during germination. J Korean Soc Food Sci Nutr 26(6), 1058-1062
  11. Kim KT, Kim SS, Lee SH, Kim DM(2003) The functionality of barley leaves and it sapplication on functional foods. Food Sci Indus 36(1), 45-49
  12. Kim YS, Kim JG, Kang IJ, Lee YS(2005) Comparison of the chemical components of buckwheat seed and sprout. J Korean Soc Food Sci Nutr 34(1), 206-211.
  13. Kim YE(2011) Effects of young barley leaf powders on the quality characteristics of yellow layer cakes. Korean J Food Preserv 18(6), 830-835 https://doi.org/10.11002/kjfp.2011.18.6.830
  14. Korean Statistical Association(2013) Annual report on the cause of death statistics. Korean Statistical Association, Seoul, Korea
  15. Kwon EJ, Kwon YS, Oh TH, Jang KH, Jang IH (2001) Serum fructosammine for assessment of glycemic control in a cat with diabetic ketoacidosis. J Vet Clin Med 18(1), 74-77
  16. Kylen AM, McCready RM(1975) Nutrients in seeds and sprouts of alfalfa, lentils, mung beans and soybeans. J Food Sci 40(5), 1008-1009 https://doi.org/10.1111/j.1365-2621.1975.tb02254.x
  17. Lee HS (2015) Anti-diabetic effects of microgreen extracts in a mouse model of type II diabetes mellitus. Ph D Thesis. Wonkwang University, Korea.
  18. Lee JH, Cho CW, Han XF, Hwang JY, Kang MJ, Joo HJ, Kim ME, Seo YJ, Kim JI(2008) Amelioration of plasma glucose and cholesterol levels in db/db mice by a mixture of Chinese herbs. Korean J Medicinal Crop Sic 16(4), 225-230
  19. Lee SH, LeeYM, Lee HS, Kim DK(2009) Anti-oxidative and anti-hyperglycemia effects of Triticum aestivum wheat sprout water extracts on the streptozotocininduced diabetic mice. Kor J Pharmacogn 40(4), 408-414
  20. Lee SZ, Park SH, Lee HS(2001) Change in vivo lipid peroxidation and antioxidant defense system in streptozotocin-induced diabetic rats : a time course study. Korean J Nutr 34(3), 253-264
  21. Lee YA, Kim HY, Cho EJ(2005) Comparison of methanol extracts from vegetables on antioxidative effect under in vitro and cell system. Korean J Soc Food Sci Nutr 34(8), 1151-1156 https://doi.org/10.3746/jkfn.2005.34.8.1151
  22. Matkovic B, Kotorman M, Varga IS, Hai DQ, Varga C(1998) Oxidative stress in experimental diabetes induced by streptozotocin. Acta Physiol Hung 85(1), 29-38
  23. Matsuo T, Odaka H, Ikeda H(1992) Effects of an intestinal disaccharidase inhibitor (AO-128) on obesity and diabetes. Am J Clin Nutr 55(1), 314S-317S https://doi.org/10.1093/ajcn/55.1.314s
  24. Mogensen CE, Anderson MJF(1973) Increased kidney size and glomerular filtration rate early juvenile diabetes. Diabetes 22(9), 706-712 https://doi.org/10.2337/diab.22.9.706
  25. Nepom GT (1990) A unified hypothesis for the complex genetics of IILA association with IDDM. Diabetes 39(10), 1153-1157 https://doi.org/10.2337/diab.39.10.1153
  26. Park GY, Lee SJ, Im JG(1997) Effect of green tea catechin on cytochrome P450, Xanthine oxidase activities in liver and liver damage in streptozotocin induced diabetic rats. J Korean Soc Food Sci Nutr 26(5), 901-907
  27. Park KS, Lee DE, Sung JH, Chung SH(2002) Comparisons of antidiabetic effect of Panax ginseng on MLD STZ-induced diabetic rats in terms of time of administration. J Ginseng Res 26(4), 191-195 https://doi.org/10.5142/JGR.2002.26.4.191
  28. Polosnsky KS, Licinio-Paixao J, Given BD, Pugh W, Rue P, Galloway J, Karrison T, Frank B(1986) Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest 77(1), 98-105 https://doi.org/10.1172/JCI112308
  29. Preton AM, Tome J, Morales JJ, Milan L, Cuevas AA, Medina J, Santiago JA(1991) Diabetic parameters 58 weeks after injection with streptozotocin in rats fed basal diet supplement with fiber, mineral and vitamins. Nutr Res 11(8), 895-906 https://doi.org/10.1016/S0271-5317(05)80617-7
  30. Reeves PG, Nielson FH, Fahey Jr GC(1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123(11), 1939-1951 https://doi.org/10.1093/jn/123.11.1939
  31. Ryu KS, Lee WC, Ku HO, Lee HS, Lee KR, Kim SY(1999) Hypoglycemic effect of mulberry leaves with anaerobic treatment in alloxan-induced diabetic mice. Kor J Pharmacogn 30(2), 123-129
  32. Seyer HK(1977) Renal hypertrophy in experimental diabetes relation to severity of diabetes. Diabetologia 13(2), 141-143. https://doi.org/10.1007/BF00745142
  33. Sochor M, Kunjara S, Baquer NZ(1991) Regulation of glucose metabolism in livers and kidneys of NOD mice. Diabetes 40(11), 1467-1471 https://doi.org/10.2337/diab.40.11.1467
  34. Song MR(2001) Volatile flavor components of cultivated radish(Raphanus sativa L.) sprout. Korean J Food Nutr 14(1), 20-27
  35. Stadtman ER, Berlett BS(1998) Reactive oxygen-mediated protein oxidation in aging and disease. Drug Metab Rev 30(2), 325-243
  36. Steer KA, Sochor M, Mclean P(1985) Renal hypertrophy in experimental diabetes changes in pentose phosphate pathway activity. Diabetes 34(5), 485-490 https://doi.org/10.2337/diab.34.5.485
  37. Suk JH, Kim MK, Ju JW, Han JS, Park JH(2006) The effect of green tea polypenol on plasma glucose, lipid levels and antioxidant system in type 2 diabetes patients. J Korean Diabetes Assoc 30(3), 217-225 https://doi.org/10.4093/jkda.2006.30.3.217
  38. Vuksan V, Korsic M, Posavi-Antonovic A(1997) Metabolic diseases and the high-fiber diet. Lijec Vjesn 119(3-4), 125-127
  39. WHO study Group(1985) Diabetes mellitus. Technical Report Series 727. Geneva, World Health Organization, pp19
  40. Wolff SP, Jiang ZY, Hunt JV(1991) Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radic Biol Med 10(5), 339-352 https://doi.org/10.1016/0891-5849(91)90040-A
  41. Yang EJ(2010) Effect of young barley leaves on lipid contents and hepatic lipid regulating enzyme activities in high-fat fed mice. MS Thesis. Sunchon National University, Korea
  42. Yoon JW, Kim CJ, Park CY, McArthur RG(1987) Effect of environmental factors on development of insulindependent diabetes mellitus. Clin Invest Med 10(5), 457-469
  43. Yu YM, Chang WC, Chang CT, Hsieh CL, Tsai CE(2002) Effects of young barley leaf extract and antioxidative vitamins on LDL oxidation and free radical scavenging activities in type 2 diabetes. Diabetes Metab 28(2), 107-114

Cited by

  1. Nutrient Composition and Antioxidative Effects of Young Barley Leaf vol.27, pp.4, 2016, https://doi.org/10.7856/kjcls.2016.27.4.851
  2. 지방분화가 유도된 3T3-L1 세포와 고지방식이로 유도된 마우스에서 보리순 물추출물의 항비만 효과 vol.25, pp.6, 2016, https://doi.org/10.7783/kjmcs.2017.25.6.367
  3. 당뇨 쥐에서 상엽추출물을 첨가한 보리면의 혈당조절효과 vol.9, pp.8, 2016, https://doi.org/10.15207/jkcs.2018.9.8.101
  4. Effects of Young Barley Leaf Powder on Anti-obesity and Lipid Improvements in Rats Fed a High-fat Diet vol.30, pp.2, 2016, https://doi.org/10.7856/kjcls.2019.30.2.211
  5. Assessment of the Potential Use of Young Barley Shoots and Leaves for the Production of Green Juices vol.11, pp.14, 2016, https://doi.org/10.3390/su11143960
  6. 새싹보리 에탄올 농도별 추출물의 산화방지 활성 vol.51, pp.5, 2016, https://doi.org/10.9721/kjfst.2019.51.5.486
  7. Quality Characteristics of Acorn Muk Added with Barley Sprout Powder vol.30, pp.2, 2020, https://doi.org/10.17495/easdl.2020.4.30.2.139
  8. Indian Gooseberry and Barley Sprout Mixture Inhibits Adipogenesis and Lipogenesis Activity in 3T3-L1 Adipocytes vol.10, pp.24, 2016, https://doi.org/10.3390/app10249078
  9. Emblica officinalis and Hordeum vulgare L. Mixture Regulates Lipolytic Activity in Differentiated 3T3-L1 Cells vol.24, pp.2, 2016, https://doi.org/10.1089/jmf.2020.4810