Journal of Food Hygiene and Safety (한국식품위생안전성학회지)

The Korean Society of Food Hygiene and Safety (한국식품위생안전성학회)
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Preliminary Monitoring of Mycotoxins for Safety Management of Medicinal Herbs

한약재 안전관리를 위한 곰팡이독소 선제적 모니터링 연구

  • Lee, Hyun-Kyung (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Kim, Ae-Kyeong (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Kim, Ouk-Hee (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Kim, Sung-Dan (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Lee, Young-Ju (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Lee, Sea-Ram (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Kim, Il-Young (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Lee, Jung-Mi (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Yu, In-Sil (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team) ;
  • Jung, Kweon (Seoul Metropolitan Government Research Institute of Public Health and Environment, Herbal Medicine Inspection Team)
  • 이현경 (서울시보건환경연구원 한약재검사팀) ;
  • 김애경 (서울시보건환경연구원 한약재검사팀) ;
  • 김욱희 (서울시보건환경연구원 한약재검사팀) ;
  • 김성단 (서울시보건환경연구원 한약재검사팀) ;
  • 이영주 (서울시보건환경연구원 한약재검사팀) ;
  • 이새람 (서울시보건환경연구원 한약재검사팀) ;
  • 김일영 (서울시보건환경연구원 한약재검사팀) ;
  • 이정미 (서울시보건환경연구원 한약재검사팀) ;
  • 유인실 (서울시보건환경연구원 한약재검사팀) ;
  • 정권 (서울시보건환경연구원 한약재검사팀)
  • Received : 2017.01.03
  • Accepted : 2017.04.05
  • Published : 2017.06.30
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Abstract

The consumption of herbal medicines has been increasing with growing interest in health. However, due to recent climate change and the complex distribution process of herbal medicines with high import dependence the likelihood of contamination with mycotoxin has been increased. Mycotoxins are emerging as key indicators for ensuring safety of herbal medicines. A total of 498 herbal medicine samples were screened for mycotoxin contamination in this study. Aflatoxin in the herbal medicine samples was extracted by using immunoaffinity column, then the extracted aflatoxin was quantified via high performance liquid chromatography coupled with fluorescence detection (HPLC-FLD) method. The extraction method was verified by linearity, recovery, LOD and LOQ. Aflatoxins were detected in 39/498 samples in an average of $7.670{\mu}g/kg$ ($0.610-77.452{\mu}g/kg$ range). Although safety standards for Corydalis Tuber is not currently available in korea, five of the 39 samples had high concentration of aflatoxins (average of $14.9{\pm}4.1{\mu}g/kg$). In conclusion, it is urgent to establish safety criteria of aflatoxin in Corydalis Tuber. The results of the current study suggest that continuous monitoring is necessary for proactive management of herbal medicine safety.

현대인들의 건강에 대한 관심이 커짐에 따라 한약재 소비량이 지속적으로 증가하고 있다. 그러나 최근 기후변화와 국내 한약재의 높은 수입 의존도에 따라 유해물질에 대한 오염 위험이 높아지고 있다. 곰팡이독소는 한약재 중 안전성을 평가하는 주요한 항목 중 하나이다. 본 연구에서 498 건의 한약재에 대해 곰팡이독소 모니터링을 진행하였다. 면역컬럼을 이용해 한약재 중 아플라톡신을 추출하였으며, 추출한 아플라톡신은 HPLC-FLD 방법을 통해 분석하였다. 직선성, 회수율, LOD 및 LOQ를 통해 본 연구에 이용한 실험법 검증을 실시하였다. 39건에서 평균 $7.670{\mu}g/kg$의 아플라톡신이 검출되었으며, $0.610{\sim}77.452{\mu}g/kg$의 검출범위를 보였다. 특히 현호색은 국내 아플라톡신 기준이 없으나, 시험에 사용된 39건 중 5건에서 $14.9{\pm}4.1{\mu}g/kg$의 높은 아플라톡신 농도를 보였다. 즉, 현호색에 대한 기준 설정이 시급히 요구되어지며, 선제적 관리를 위한 지속적인 모니터링이 필요할 것으로 사료되어진다.

Keywords

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