DOI QR코드

DOI QR Code

Effects of Electroacupuncture at Zusanli (ST36) on Ultrasonographic Gastric Emptying: A Pilot Study in Healthy Adults

족삼리 전침 자극이 초음파로 측정된 위배출능에 미치는 영향 : 건강인 대상 예비연구

  • Ha, Na-yeon (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Park, Jae-woo (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Kim, Jin-sung (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 하나연 (경희대학교 대학원 임상한의학과) ;
  • 박재우 (경희대학교 대학원 임상한의학과) ;
  • 김진성 (경희대학교 대학원 임상한의학과)
  • Received : 2018.05.21
  • Accepted : 2018.06.27
  • Published : 2018.06.30

Abstract

Objective: This study aimed to compare the effects of Zusanli and nonacupoint electroacupuncture stimulation on ultrasonographic gastric emptying and vital signs in eight healthy participants. Gastric emptying and its rate of change were analyzed to search for correlation with physical characteristics such as body mass index (BMI), sternocostal angle, and abdominal wall thickness. Methods: Eight healthy participants with no gastrointestinal disorders were enrolled in this study. Each participant went through three abdominal sonographies for gastric emptying assessment. At the second and third visits, participants received Zusanli and nonacupoint electroacupuncture stimulation in a random order. During the study period, we examined the BMI, sternocostal angle, and abdominal wall thickness of all participants. Vital signs (blood pressure, heart rate, and temperature) were also examined before and after the electroacupuncture stimulation. Results: Electroacupuncture stimulation at Zusanli significantly improved gastric emptying when compared to nonacupoint stimulation. Gastric emptying showed a positive correlation with BMI, sternocostal angle, and abdominal wall thickness, but this correlation was statistically insignificant. The improvement rate of gastric emptying by Zusanli electroacupuncture stimulation showed a positive correlation with BMI and sternocostal angle and a negative correlation with abdominal wall thickness. However, such results were also statistically insignificant. Among vital signs, only heart rate showed a significant decrease according to Zusanli electroacupuncture stimulation. Conclusions: A significant effect of Zusanli electroacupuncture was confirmed through ultrasonographic gastric emptying in healthy participants.

Keywords

References

  1. Ford AC, Forman D, Bailey AG, Axon AT, Moayyedi P. Initial poor quality of life and new onset of dyspepsia: results from a longitudinal 10-year follow-up study. Gut 2007;56(3):321-7. https://doi.org/10.1136/gut.2006.099846
  2. Pang B, Jiang T, Du YH, Li J, Li B, Hu YC, et al. Acupuncture for Functional Dyspepsia: What Strength Does It Have? A Systemic Review and Meta-Analysis of Randomized Controlled Trials. Evid Based Complement Alternat Med 2016:1-17.
  3. Shen D, Liu B, Wi D, Zhang F, Chen Y. Effects of electroacupuncture on central and peripheral monoamine neurotransmitter in the course of protecting rat stress peptic ulcer. Zhen Ci Yan Jiu 1994;19(1):51-4.
  4. Qian L, Peters LJ, Chen JD. Effects of electroacupuncture on gastric migrating myoelectrical complex in dogs. Dig Dis Sci 1999;44(1):56-62. https://doi.org/10.1023/A:1026645931867
  5. Kim JJ. The latest acupuncture. Seoul: Seongbosa; 1995, p. 211-3.
  6. National Korean medicine university acupuncture & meridian class. Acupuncrue & Moxibustion. Seoul: Jibmoondang; 1994, p. 382-4, 648-9.
  7. Byun JY, Son IC, Um TS. A bibliographical study about the blood characteristics of Joksamni and Kwanwon points. The J of Korean Acupuncture & Moxibustion Society 1992;9(1):173-8.
  8. Yoon SW, Park JW. The effect of Boikyangwi-tang on Functional Dyspepsia Using Water Load Test; a Pilot Study. J Int Korean Med 2006;fal:161-9.
  9. Malagelada JR. Gastrointestinal motor disturbances in functional dyspepsia. Scan J Gastroenterol 1991;182:29-32.
  10. Lee HW, Park HJ, Lee SI, Park IS, Kang BC, Kim KW. Ultrasonographic Gastric Emptying in Patients with Functional Dyspepsia. The Korean J of Gastroenterology 1998;31(1):1-8.
  11. Chen JY, Pan F, Xu JJ. Effects of acupuncture on the gastric motivity in patients with functional dyspepsia. Zhongguo Zhong Xi Yi Jie He Za Zhi 2005;25(10):880-2.
  12. Mauro C, Federico M, Danlele D, Jane IW. Randomized Trial of Acupuncture Compared With Prokinetic Drugs And Sham Acupuncture For Chronic Idiopathic Dyspepsia. Medical Acupuncture 2003;14(2):17-8.
  13. Ren QY, Zhang C, Huan YX, Whang JJ. Effect of acupuncture at Zusanli on gastric emptying and the changes of related hormone levels in patients with functional dyspepsia. Shanxi Yike Daxue Xuebao 2010;41(9):819-21.
  14. Shiotani A, Tatewaki M, Hoshino E, Takahashi T. Effects of electroacupuncture on gastric myoelectrical activity in healthy humans. Neurogastroenterol Motil 2004;16(3):293-8. https://doi.org/10.1111/j.1365-2982.2004.00504.x
  15. Tougas G, Yuan LY, Radamaker JW, Chiverton SG, Hunt RH. Effect of acupuncture on gastric acid secretion in healthy male volunteers. Dig Dis Sci 1992;37(10):1576-82. https://doi.org/10.1007/BF01296505
  16. Lee HS, Cha SJ, Pakr HJ, Seo JC, Park JB, Lee HJ. Revised STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) : Extending the CONSORT Statement. Korean J Acup 2010;27(3):1-23.
  17. Kim YS, Yoon SB. Combination Effects of Zusanli(ST36) Electroacupuncture and Manual Acupuncture of other Acupoints on Gastric Vagal Nerve Activity and Pyloric Valve Function in Patients with Functional Dyspepsia. J Int Korean Med 2008;29(3):621-8.
  18. Van de Putte P, Perlas A. Ultrasound assessment of gastric content and volume. Br J Anaesth 2014;113(1):12-22. https://doi.org/10.1093/bja/aeu151
  19. Baek SH, Kim JS. Correlation Analysis between Gastric Emptying Measured by Ultrasonography and Spleen Qi Deficiency Pattern in Patients with Functional Dyspepsia. J Int Korean Med 2015;36(4):527-46.
  20. Kim DY, Jung HK, Lee YH, Jung SA, Moon IW, Paek JY. The measurement of gastric emptying time with 3-D ultrasonography. The Korean J of gastroenterology 2004;44(2):71-6.
  21. Son JY, Kim JS. Diagnostic Values of Tongue Coating Thickness and Sterno-costal Angle in Functional Dyspepsia. J Int Korean Med 2014;35(2):157-74. https://doi.org/10.13048/jkm.14015
  22. Han SJ, Park JW, Kim JS. Measuring the Thickness of the Abdominal Wall at Abdominal Acupoints Using Ultrasonography and Analyzing Correlations with Physical Examination Values in Functional Dyspepsia Patients. J Int Korean Med 2016;37(6):998-1011. https://doi.org/10.22246/jikm.2016.37.6.998
  23. Jin HO, Zhou L, Lee KY, Chang TM, Chey WY. Inhibition of acid secretion by electrical acupuncture is mediated via beta-endorphin and somatostatin. Am J Physiol 1996;271(3):524-30. https://doi.org/10.1152/ajpcell.1996.271.2.C524
  24. Qian L, Peters LJ, Chen JD. Effects of electroacupuncture on gastric migrating myoelectrical complex in dogs. Dig Dis Sci 1999;44(1):56-62. https://doi.org/10.1023/A:1026645931867
  25. Chen J, Song GQ, Yin J, Koothan T, Chen JD. Electro acupuncture improves impaired gastric motility and slow waves induced by rectal distension in dogs. Am J Physiol Gastrointest Liver Physiol 2008;295(3):G614-20. https://doi.org/10.1152/ajpgi.90322.2008
  26. Chen Y, Xu JJ, Liu S, Hou XH. Electroacupuncture at ST36 a meliorates gastric emptying and rescues networks of interstitial cells of Cajal in the stomach of diabetic rats. PloS One 2013;8:e83904. https://doi.org/10.1371/journal.pone.0083904
  27. Ouyang H, Xing J, Chen J. Electroacupuncture restores impaired gastric accommodation in vagotomized dogs. Dig Dis Sci 2004;49(9):1418-24. https://doi.org/10.1023/B:DDAS.0000042240.05247.01
  28. Qian L, Peters LJ, Chen JD. Effects of electroacupuncture on gastric migrating myoelectrical complex in dogs. Dig Dis Sci 1999;44(1):56-62. https://doi.org/10.1023/A:1026645931867
  29. Lee HS, Lim JG. Effect of Joksamni acupuncture on gastric motility of rabbit. The J of Korean Med 1981;2(1):27-37.
  30. Jang KH, Kim MD, Yu YC. Effects of Long Term Stimulated Acupuncture at ST 36 on the Serum Gastrin Level in Rats. Korean J of Oriental Physiology & Pathology 2003;17(3):672-6.
  31. Park JK, Shin CM, Lee H, Yoon YH, Song KH, Min BH, et al. Current Issues in Functional Dyspepsia. Korean J Gastroenterol 2014;64(3):133-41. https://doi.org/10.4166/kjg.2014.64.3.133
  32. Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology 2006;130(5):1377-90. https://doi.org/10.1053/j.gastro.2006.03.008
  33. Sarnelli G, Gaenepeel P, Geypens B, Janssesn J, Tack J. Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia. Am J Gastroenterol 2003;98(4):783-8. https://doi.org/10.1111/j.1572-0241.2003.07389.x
  34. Perlas A, Mitsakakis N, Liu L, Cino M, Haldipur N, Davis L, et al. Validation of Mathematical Model for Ultrasound Assessment of Gastric Volume by Gastroscopic Examination. Anesth Analg 2013;116(2):357-63. https://doi.org/10.1213/ANE.0b013e318274fc19
  35. Lee S, Park HK, Kim SM, Kwon HS, Kim DY, Kim DJ, et al. Cut-off points of waist circumference for defining abdominal obesity in the Korean population. The Korean Journal of Obesity 2006;15(1):1-9.
  36. Yang R. Chinese medicine disease predication. Seoul: Beobinmoonwhasa; 2001, p. 205-64.
  37. Joh KH, Kita T, Terasawa K, Moon SK, Ko CN, Kim YS, et al. An Introduction of Abdominal Palpation Signs In Japanese Oriental Medicine-A New Approach To The Practive Of Abdominal Palpation In Korean Oriental Medicine-. J Int Korean Med 1997;18(1):86-96.
  38. Lee YC, Kang JS. Study on the Diagnosis of the Abdominal Region from Physiological Viewpoint. Korean J Oriental Physiology & Pathology 2004;18(2):349-54.
  39. Lee JC, Kim SH. Overview on the Sasang Constitutional Abdominal Examination based on Experienced Prescriptions in the Donguisusebowon. Korean J Oriental Physiology & Pathology 2012;26(2):141-6.
  40. Kim JC, Choi MK, Jung WK, Yoo JS, Shin WY, Kim SH. A Study on the Sasang Constitutional Checkup List and Inspection Diagnosis of Face and Tongue. J Sasang Constitut Med 2007;19(3):156-75.
  41. Kim MS, Gwag MA, Jang US, Lee GT, Jeong GS, Jeong TY, et al. Effect of Electroacupuncture Stimulation on Heart Rate Variability in Healthy Adults. The J of Korean Acupuncture & Moxibustion Society 2003;20(4):157-69.
  42. Nishijo K, Mori H, Yosikawa K, Yazawa K. Decreased heart rate by acupuncture stimulation in humans via facilitation of cardiac vagal activity and suppression of cardiac sympathetic nerve. Neurosci Lett 1997;227(3):165-8. https://doi.org/10.1016/S0304-3940(97)00337-6
  43. Lee MS, Kim JH, Cho SW, Shim CS. Real-time ultrasonographic measurement of gastric emptying time. Korean J Med 1990;39(6):749-57.
  44. Hveem K, Jones KL, Chatterton BE, Horowitz M. Scintigraphic measurement of gastric emptying and ultrasonographic assessment of antral area: relation to appetite. Gut 1996;38(6):816-21. https://doi.org/10.1136/gut.38.6.816
  45. Choi SC, Seo GS, Kim JA, Nah YH, Lee CH. Influence of age and gender on solid gastric emptying. Korean J Gastroenterol 1998;31(1):9-15.

Cited by

  1. A Review of the Clinical Use of Ultrasound in Korean Traditional Medicine vol.36, pp.4, 2018, https://doi.org/10.13045/jar.2019.00297